Browsing Department of Clinical Science by Document Types "Journal article"
Now showing items 41-60 of 1946
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Airway symptoms and atopy in young children prescribed asthma medications: A large‐scale cohort study
(Peer reviewed; Journal article, 2019)Diagnosing asthma and deciding treatment are difficult in young children. An inappropriate and too high prescription rate of inhaled corticosteroids (ICS) is suggested, but how airway symptoms are associated with prescriptions ... -
The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury
(Journal article; Peer reviewed, 2022)Objective To compare the concentrations of high mobility group box 1 protein (HMGB1) and S100A8/A9 in synovial fluid between patients with knee injuries and osteoarthritis (OA), and knee healthy subjects. To investigate ... -
Alcohol at bedtime induces minor changes in sleep stages and blood gases in stable chronic obstructive pulmonary disease
(Peer reviewed; Journal article, 2014-05-17)Purpose/background: The purpose of this study is to explore the effect of a moderate dose of alcohol on sleep architecture and respiration in chronic obstructive pulmonary disease (COPD). Alcohol depresses both hypercapnic ... -
Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis
(Journal article; Peer reviewed, 2022)Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that can lead to cirrhosis and hepatic decompensation. However, predicting future outcomes in patients with PSC is challenging. Our ... -
All-Optical Electrophysiology in hiPSC-Derived Neurons With Synthetic Voltage Sensors
(Journal article; Peer reviewed, 2021)Voltage imaging and “all-optical electrophysiology” in human induced pluripotent stem cell (hiPSC)-derived neurons have opened unprecedented opportunities for high-throughput phenotyping of activity in neurons possessing ... -
Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients
(Peer reviewed; Journal article, 1992-11)We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot ... -
Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations
(Peer reviewed; Journal article, 2019-02)Genome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of ... -
Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study
(Journal article; Peer reviewed, 2023)Objective: Increased prevalence of cardiovascular disease has been reported in autoimmune Addison's disease (AAD), but pathomechanisms are poorly understood. Design: Cross-sectional study. Methods: We compared serum ... -
Altered development of fetal liver perfusion in pregnancies with pregestational diabetes
(Peer reviewed; Journal article, 2019-03-13)Background: Pregestational diabetes is associated with fetal macrosomia, and umbilical perfusion of the fetal liver has a role in regulating fetal growth. We therefore hypothesized that pregestational diabetes alters fetal ... -
Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis
(Journal article; Peer reviewed, 2021)Background & Aims To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. ... -
Altered immune activation and IL-23 signaling in response to Candida albicans in autoimmune polyendocrine syndrome type 1
(Peer reviewed; Journal article, 2017-09-01)Objective: Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare, childhood onset disease caused by mutations in the autoimmune regulator (AIRE) gene. Chronic mucocutaneous candidiasis (CMC) is one of the three major ... -
Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren's syndrome
(Peer reviewed; Journal article, 2014-08-11)Introduction: Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system, involved in both initiating immune responses and maintaining tolerance. Dysfunctional and via toll-like receptor (TLR) ... -
Amniotic fluid arginine from gestational weeks 13 to 15 is a predictor of birth weight, length, and head circumference
(Peer reviewed; Journal article, 2017-12-14)Arginine is a constituent of proteins and a precursor for polyamines and nitric oxide, and is essential for placentation, angiogenesis, and growth. Maternal plasma arginine concentrations are found to be lower in pregnancies ... -
Analyses of Increased Mortality in New and Known Diabetes in Patients with Coronary Disease Enrolled in the NORSTENT Randomized Study
(Journal article; Peer reviewed, 2021)Background: NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention with drug-eluting stents (DES) or bare-metal stents (BMS) with a 5-year follow-up. Among the patients, 5,512 had measured either ... -
Analysing microbiome intervention design studies: Comparison of alternative multivariate statistical methods
(Journal article; Peer reviewed, 2021)The diet plays a major role in shaping gut microbiome composition and function in both humans and animals, and dietary intervention trials are often used to investigate and understand these effects. A plethora of statistical ... -
Analysis of cellular and humoral immune responses against cytomegalovirus in patients with autoimmune Addison’s disease
(Peer reviewed; Journal article, 2016-03-09)Background. Autoimmune Addison’s disease (AAD) is caused by multiple genetic and environmental factors. Variants of genes encoding immunologically important proteins such as the HLA molecules are strongly associated with ... -
Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia
(Peer reviewed; Journal article, 2018-12-11)Introduction: The persistence of schizophrenia in human populations separated by geography and time led to the evolutionary hypothesis that proposes schizophrenia as a by-product of the higher cognitive abilities of modern ... -
Analysis of host-pathogen gene association networks reveals patient-specific response to streptococcal and polymicrobial necrotising soft tissue infections
(Journal article; Peer reviewed, 2022)Background: Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial infections usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial ... -
Analytical considerations in deriving 99th percentile upper reference limits for high-sensitivity cardiac troponin assays: Educational recommendations from the IFCC committee on clinical application of cardiac bio-markers
(Journal article; Peer reviewed, 2022)The International Federation of Clinical Chemistry Committee on Clinical Application of Cardiac Bio-Markers provides evidence-based educational documents to facilitate uniform interpretation and utilization of cardiac ... -
Analytical performance of cardiac troponin assays – Current status and future needs
(Journal article; Peer reviewed, 2020)Concurrent with the introduction of cardiac troponin measurements into the diagnostic definition of myocardial infarction (MI), clinicians and laboratory professionals signaled a clear clinical need for improved analytical ...