Department of Clinical Science: Recent submissions

Now showing items 141-160 of 2318

    • European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma 

      Sorbye, Halfdan; Grande, Enrique; Pavel, Marianne; Tesselaar, Margot; Fazio, Nicola; Reed, Nicholas Simon; Knigge, Ulrich; Christ, Emanuel; Ambrosini, Valentina; Couvelard, Anne; Tiensuu Janson, Eva (Journal article; Peer reviewed, 2023)
      This ENETS guidance paper, developed by a multidisciplinary working group, provides up-to-date and practical advice on the diagnosis and management of digestive neuroendocrine carcinoma, based on recent developments and ...

    • Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role? 

      Køstner, Anne Helene; Fuglestad, Anniken Jørlo; Georgsen, Jeanette Baehr; Nielsen, Patricia Switten; Christensen, Kristina Bang; Zibrandtsen, Helle; Parner, Erik Thorlund; Rajab, Ibraheem M.; Potempa, Lawrence A.; Steiniche, Torben; Kersten, Christian (Journal article; Peer reviewed, 2023-03-17)
      Background: Systemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types. CRP exists ...

    • Training of medical students in the use of emergency whole blood collection and transfusion in the framework of a civilian walking blood 

      Apelseth, Torunn Oveland; Kristoffersen, Einar Klæboe; Strandenes, Geir; Hervig, Tor Audun (Journal article; Peer reviewed, 2023)
      Introduction: In this report, we describe a training program in emergency whole blood collection and transfusion for medical students at the University of Bergen. The overall aim of the program is to improve the availability ...

    • Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure 

      de Koning, Marie-Sophie L. Y.; Emmens, Johanna E.; Romero-Hernández, Esteban; Bourgonje, Arno R.; Assa, Solmaz; Figarska, Sylwia M.; Cleland, John G. F.; Samani, Nilesh J.; Ng, Leong L.; Lang, Chim C.; Metra, Marco; Filippatos, Gerasimos S.; van Veldhuisen, Dirk J.; Anker, Stefan D.; Dickstein, Kenneth; Voors, Adriaan A.; Lipsic, Erik; van Goor, Harry; van der Harst, Pim (Journal article; Peer reviewed, 2023)
      Background: Oxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum-free thiol concentrations, as a marker of systemic oxidative stress, in HF ...

    • Enhancing Public Health Communication Regarding Vaccine Trials: Design and Development of the Pan-European VACCELERATE Toolkit 

      Argyropoulos, Christos D.; Leckler, Janina; Salmanton-García, Jon; Constantinou, Marinos; Alexandrou, Alexandra; Themistocleous, Sophia; Noula, Evgenia; Shiamakkides, George; Nearchou, Andria; Stewart, Fiona A.; Albus, Kerstin; Koniordou, Markela; Kopsidas, Ioannis; Spivak, Orly; Hellemans, Margot; Hendrickx, Greet; Davis, Ruth Joanna; Azzini, Anna Maria; Simon, Paula Valle; Carcas-Sansuan, Antonio Javier; Askling, Helena Hervius; Vene, Sirkka; Prellezo, Jana Baranda; Álvarez-Barco, Elena; Macken, Alan J.; Di Marzo, Romina; Luís, Catarina; Olesen, Ole F.; Frias Iniesta, Jesus A.; Barta, Imre; Tóth, Krisztina; Akova, Murat; Bonten, Marc M.J.; Cohen-Kandli, Miriam; Cox, Rebecca Jane; Součková, Lenka; Husa, Petr; Jancoriene, Ligita; Launay, Odile; Lundgren, Jens; Mallon, Patrick; Armeftis, Charis; Marques, Laura; Naucler, Pontus; Ochando, Jordi; Tacconelli, Evelina; van Damme, Pierre; Zaoutis, Theoklis; Hofstraat, Sanne; Bruijning-Verhagen, Patricia; Zeitlinger, Markus; Cornely, Oliver A.; Pana, Zoi Dorothea (Journal article; Peer reviewed, 2023)
      Background: The pan-European VACCELERATE network aims to implement the first transnational harmonized and sustainable vaccine trial Volunteer Registry, being a single entry point for potential volunteers of large-scale ...

    • Current transfusion practice and need for new blood products to ensure blood supply for patients with major hemorrhage in Europe 

      Apelseth, Torunn Oveland; Doyle, Barry; Evans, Ryan; George, Chloe; Humbrecht, Catherine; Klei, Thomas; Najdovski, Tome; Sigurjonsson, Olafur E.; Wiltshire, Michael; de Korte, Dirk (Journal article; Peer reviewed, 2023)
      Background: New blood products are considered for treatment of patients with major hemorrhage. The aim of this report is to describe the current transfusion practices in Europe for patients with major hemorrhage and explore ...

    • The effect of electroconvulsive therapy (ECT) on serum kynurenine pathway metabolites in late-life depression 

      Aarsland, Tore Ivar Malmei; Haavik, Jan; Ulvik, Arve; Ueland, Per Magne; Dols, Annemiek; Kessler, Ute (Journal article; Peer reviewed, 2023)
      Background: Depression is reportedly associated with alterations in kynurenine pathway metabolites (kynurenines). Several kynurenines are involved in glutamate signaling, and some have potentially neurotoxic effects while ...

    • Impact of aortic valve stenosis on myocardial deformation in different left ventricular levels: A three-dimensional speckle tracking echocardiography study 

      Hjertaas, Johannes Just; Einarsen, Eigir; Gerdts, Eva; Kokorina, Marina Victorovna; Moen, Christian Arvei; Urheim, Stig; Saeed, Sahrai; Matre, Knut (Journal article; Peer reviewed, 2023)
      Background: Global systolic left ventricular (LV) myocardial function progressively declines as degenerative aortic valve stenosis (AS) progresses. Whether this results in uniformly distributed deformation changes from ...

    • Phenotypic diversity of human adipose tissue-resident NK cells in obesity 

      Haugstøyl, Martha; Cornillet, Martin; Strand, Kristina; Stiglund, Natalie; Sun, Dan; Lawrence-Archer, Laurence; Hjellestad, Iren Drange; Busch, Christian; Mellgren, Gunnar; Björkström, Niklas K.; Fernø, Johan (Journal article; Peer reviewed, 2023-02-22)
      Natural killer (NK) cells have emerged as key mediators of obesity-related adipose tissue inflammation. However, the phenotype of NK cell subsets residing in human adipose tissue are poorly defined, preventing a detailed ...

    • Neonatal outcomes associated with time from a high fetal blood lactate concentration to operative delivery 

      Berge, Magnus Bollum; Kessler, Jørg; Yli, Branislava Markovic; Staff, Anne Cathrine; Gunnes, Nina; Jacobsen, Anne Flem (Journal article; Peer reviewed, 2023)
      Introduction: Adjunctive technologies to cardiotocography intend to increase the specificity of the diagnosis of fetal hypoxia. If correctly diagnosed, time to delivery could affect neonatal outcome. In the present study, ...

    • Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider 

      Rodríguez-Carrio, Javier; Burska, Agata; Conaghan, P.G.; Dik, Willem A; Biesen, Robert; Eloranta, Maija-Leena; Cavalli, Giulio; Visser, Marianne; Boumpas, Dimitrios T; Bertsias, George; Wahren Herlenius, Marie Elisabeth; Rehwinkel, Jan; Frémond, Marie-Louise; Crow, Mary K; Ronnblom, Lars; Vital, Ed; Versnel, Marjan (Journal article; Peer reviewed, 2023)
      Background: Type I interferons (IFN-I) contribute to a broad range of rheumatic and musculoskeletal diseases (RMDs). Compelling evidence suggests that the measurement of IFN-I pathway activation may have clinical value. ...

    • Exploring the Patient Perspective of Bone Sarcoma Survivors Who Have Undergone Particle Radiotherapy Abroad 

      Fauske, Lena; Jebsen, Nina Louise; Bondevik, Hilde; Bruland, Øyvind (Journal article; Peer reviewed, 2023)
      Background/Aim: Sarcoma patients’ experiences of their health-related quality of life and late effects following particle therapy are sparse. Such knowledge is essential to optimize treatment compliance and follow-up care ...

    • Validation of a modified South African triage scale in a high-resource setting: a retrospective cohort study 

      Markussen, Dagfinn Lunde; Brevik, Heidi Synnøve; Bjørneklett, Rune Oskar; Engan, Mette (Journal article; Peer reviewed, 2023-03-20)
      Background: Triage systems are widely used in emergency departments, but are not always validated. The South African Triage Scale (SATS) has mainly been studied in resource-limited settings. The aim of this study was to ...

    • An external quality assessment feasibility study; cross laboratory comparison of haemagglutination inhibition assay and microneutralization assay performance for seasonal influenza serology testing: A FLUCOP study 

      Waldock, Joanna; Weiss, Carol D.; Wang, Wei; Levine, Min Z.; Jefferson, Stacie N.; Ho, Sammy; Hoschler, Katja; Londt, Brandon Z.; Masat, Elisa; Carolan, Louise; Sánchez-Ovando, Stephany; Fox, Annette; Watanabe, Shinji; Akimoto, Miki; Sato, Aya; Kishida, Noriko; Buys, Amelia; Maake, Lorens; Fourie, Cardia; Caillet, Catherine; Raynaud, Sandrine; Webby, Richard J.; DeBeauchamp, Jennifer; Cox, Rebecca Jane; Jalloh, Sarah Larteley Lartey; Trombetta, Claudia M.; Marchi, Serena; Montomoli, Emanuele; Sanz-Muñoz, Iván; Eiros, José María; Sánchez-Martínez, Javier; Duijsings, Danny; Engelhardt, Othmar G. (Journal article; Peer reviewed, 2023)
      Introduction: External Quality Assessment (EQA) schemes are designed to provide a snapshot of laboratory proficiency, identifying issues and providing feedback to improve laboratory performance and inter-laboratory agreement ...

    • Exploratory analyses on the effect of time since last meal on concentrations of amino acids, lipids, one-carbon metabolites, and vitamins in the Hordaland Health Study 

      Anfinsen, Åslaug Matre; Rosendahl-Riise, Hanne; Nygård, Ottar Kjell; Tell, Grethe S.; Ueland, Per Magne; Ulvik, Arve; McCann, Adrian; Dierkes, Jutta; Lysne, Vegard (Journal article; Peer reviewed, 2023)
      Purpose Dietary intake may have pronounced effects on circulating biomarker concentrations. Therefore, the aim was to provide a descriptive overview of serum metabolite concentrations in relation to time since last meal, ...

    • Self-management and hospitalization in 615 Swedish patients with Addison's disease during the coronavirus disease 2019 pandemic: a retrospective study 

      Öster, Sara; Esposito, Daniela; Aranda-Guillén, Maribel; Åkerman, Anna-Karin; Wahlberg, Jeanette; Husebye, Eystein Sverre; Kämpe, Olle; Botusan, Ileana Ruxandra; Dahlqvist, Per; Bergthorsdottir, Ragnhildur; Bensing, Sophie (Journal article; Peer reviewed, 2023)
      Objective Autoimmune Addison's disease (AAD) entails a chronic adrenal insufficiency and is associated with an increased risk of severe infections. It is, however, unknown how patients with AAD were affected by the ...

    • Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of immature neutrophil cells with association to lipid changes 

      Torsvik, Anja; Brattbakk, Hans-Richard; Trentani, Andrea; Holdhus, Rita; Stansberg, Christine; Bartz-Johannessen, Christoffer; Hughes, Timothy; Steen, Nils Eiel; Melle, Ingrid; Djurovic, Srdjan; Andreassen, Ole; Steen, Vidar Martin (Journal article; Peer reviewed, 2023)
      Schizophrenia (SCZ) and bipolar disorder (BD) share clinical characteristics, genetic susceptibility, and immune alterations. We aimed to identify differential transcriptional patterns in peripheral blood cells of patients ...

    • Bidirectional genetic overlap between autism spectrum disorder and cognitive traits 

      Hope, Sigrun; Shadrin, Alexey; Lin, Aihua; Bahrami, Shahram; Rødevand, Linn; Frei, Oleksandr; Hübenette, Saira Jameela; Cheng, Weiqiu; Hindley, Guy; Nag, Heidi Elisabeth; Ulstein, Line; Efrim-Budisteanu, Magdalena; O’Connell, Kevin; Dale, Anders; Djurovic, Srdjan; Nærland, Terje; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Autism spectrum disorder (ASD) is a highly heritable condition with a large variation in cognitive function. Here we investigated the shared genetic architecture between cognitive traits (intelligence (INT) and educational ...

    • Pregestational maternal risk factors for preterm and term preeclampsia: A population-based cohort study 

      Sande, Anne Kvie; Dalen, Ingvild; Torkildsen, Erik Andreas; Sande, Ragnar; Morken, Nils-Halvdan (Journal article; Peer reviewed, 2023)
      Introduction Most studies on factors affecting the risk of preeclampsia have not separated preterm from term preeclampsia, and we still know little about whether the predisposing conditions have a differentiated effect ...

    • Virtual reality simulation training in stroke thrombectomy centers with limited patient volume—Simulator performance and patient outcome 

      Søvik, Olav; Tveiten, Arnstein; Øygarden, Halvor; Stokkeland, Pål Johan; Hetland, Hanne Brit; Schneider, Magnus Sundgot; Sandve, Knut Olav Lende; Altmann, Marianne; Hykkerud, Dan L; Ospel, Johanna; Goyal, Mayank; Ersdal, Hege Langli; Kurz, Martin; Hyldmo, Per Kristian (Journal article; Peer reviewed, 2023)
      Background Virtual reality simulation training may improve the technical skills of interventional radiologists when establishing endovascular thrombectomy at limited-volume stroke centers. The aim of this study was to ...