Department of Clinical Science: Nye registreringer

Viser treff 121-140 av 2318

    • Vaccination prevents severe COVID-19 outcome in patients with neutralizing type 1 interferon autoantibodies 

      Wolff, Anette Susanne Bøe; Hansen, Lena; Grytaas, Marianne Aardal; Oftedal, Bergithe Eikeland; Breivik, Lars Ertesvåg; Zhou, Fan; Hufthammer, Karl Ove; Sjøgren, Thea; Olofsson, Jan Stefan; Trieu, Mai Chi; Meager, Anthony; Jørgensen, Anders Palmstrøm; Lima, Kari; Mohn, Kristin Greve-Isdahl; Langeland, Nina; Cox Brokstad, Rebecca Jane; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2023)
      A hallmark of patients with autoimmune polyendocrine syndrome type 1 (APS-1) is serological neutralizing autoantibodies against type 1 interferons (IFN-I). The presence of these antibodies has been associated with severe ...

    • Hospitalization for acute heart failure during non-working hours impacts on long-term mortality: the REPORT-HF registry 

      Katsanos, Spyridon; Ouwerkerk, Wouter; Farmakis, Dimitrios; Collins, Sean P.; Angermann, Christiane E.; Dickstein, Kenneth; Tomp, Jasper; Ertl, Georg; Cleland, John; Dahlström, Ulf; Obergfell, Achim; Ghadanfar, Mathieu; Perrone, Sergio V.; Hassanein, Mahmoud; Stamoulis, Konstantinos; Parissis, John; Lam, Carolyn; Filippatos, Gerasimos (Journal article; Peer reviewed, 2023)
      Aims Hospital admission during nighttime and off hours may affect the outcome of patients with various cardiovascular conditions due to suboptimal resources and personnel availability, but data for acute heart failure ...

    • Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells 

      Steiner, Ivana; Flores-Tellez, Teresita del N.J.; Mevel, Renaud; Ali, Amin; Wang, Pengbo; Schofield, Pieta; Behan, Caron; Forsythe, Nicholas; Ashton, Garry; Taylor, Catherine; Mills, Ian Geoffrey; Oliveira, Pedro; McDade, Simon S.; Zaiss, Dietmar M.; Choudhury, Ananya; Lacaud, Georges; Baena, Esther (Journal article; Peer reviewed, 2023)
      The emergence of castration-resistant prostate cancer remains an area of unmet clinical need. We recently identified a subpopulation of normal prostate progenitor cells, characterized by an intrinsic resistance to androgen ...

    • Systolic myocardial function measured by echocardiographic speckle-tracking and peak oxygen consumption in pediatric childhood cancer survivors—a PACCS study 

      Engan, Britt; Diab, Simone; Brun, Henrik; Raastad, Truls; Torsvik, Ingrid Kristin; Omdal, Tom Roar; Zamanzad Ghavidel, Fatemeh; Greve, Gottfried; Ruud, Ellen; Edvardsen, Elisabeth; Leirgul, Elisabeth (Journal article; Peer reviewed, 2023)
      Background: Cancer therapy-related cardiotoxicity is a major cause of cardiovascular morbidity in childhood cancer survivors. The aims of this study were to investigate systolic myocardial function and its association to ...

    • “The challenge is the complexity” – A qualitative study about decision-making in advanced lung cancer treatment 

      Orstad, Silje; Fløtten, Øystein; Madebo, Tesfaye; Gulbrandsen, Pål; Strand, Roger; Lindemark, Frode; Fluge, Sverre; Tilseth, Rune Hørgård; Schaufel, Margrethe Aase (Journal article; Peer reviewed, 2023)
      Introduction The value of shared decision-making and decision aids (DA) has been well documented yet remain difficult to integrate into clinical practice. We wanted to investigate needs and challenges regarding ...

    • A survey of total IgE reference intervals reported by Scandinavian and British medical laboratories – a need for harmonisation 

      Vinnes, Erik Wilhelm; Sletten, Ida Sofie Karlsen; Alnæs, Marie Bjørbak; Storaas, Torgeir; Aarsand, Aasne Karine (Journal article; Peer reviewed, 2023)
      Objectives There appears to be marked discrepancies between total IgE reference intervals (RIs) in use by many laboratories and those recommended by published studies. The aim of this study was therefore to review total ...

    • Renal function, sex and age influence purines and pyrimidines in urine and could lead to diagnostic misinterpretation 

      Salvador, Cathrin Lytomt; Flemmen, Per Tryggve Kjelland; Tøndel, Camilla; Bliksrud, Yngve Thomas; Tsui, Ellen Fun Fong; Brun, Atle; Bjerre, Anna Kristina; Mørkrid, Lars (Journal article; Peer reviewed, 2023)
      Glomerular filtration rate (GFR) is commonly used in clinical practice for the diagnosis and follow-up of chronic kidney disease. Screening for inborn errors of metabolism (IEM) is based on analysis of biomarkers in urine, ...

    • β2-adrenergic receptor expression in patients receiving bevacizumab therapy for metastatic melanoma 

      Schuster, Cornelia; Akslen, Lars Andreas; Straume, Oddbjørn (Journal article; Peer reviewed, 2023)
      Background Vascular endothelial growth factor (VEGF) was initially known as vascular permeability factor and identified as a driver of tumour angiogenesis. Recently, its role in supporting an immunosuppressive tumour ...

    • Heart function by M-mode and tissue Doppler in the early neonatal period in neonates with fetal growth restriction 

      Nestaas, Eirik; Bjarkø, Lisa; Kiserud, Torvid; Haugen, Guttorm Nils; Fugelseth, Drude (Journal article; Peer reviewed, 2023)
      Background: Fetal growth restricted (FGR) neonates have increased risk of circulatory compromise due to failure of normal transition of circulation after birth. Aim: Echocardiographic assessment of heart function in FGR ...

    • Retention Time and Fragmentation Predictors Increase Confidence in Identification of Common Variant Peptides 

      Skiadopoulou, Dafni; Vasicek, Jakub; Kuznetsova, Ksenia; Bouyssié, David; Käll, Lukas; Vaudel, Marc (Journal article; Peer reviewed, 2023)
      Precision medicine focuses on adapting care to the individual profile of patients, for example, accounting for their unique genetic makeup. Being able to account for the effect of genetic variation on the proteome holds ...

    • Correlating local and systemic tumor-associated inflammation in colon cancer : CRP and the tumor immune microenvironment 

      Køstner, Anne Helene (Doctoral thesis, 2023-12-14)
      Bakgrunn: Markører for systemisk inflammasjon er assosiert med dårlig prognose i en rekke ulike kreft typer, inkludert tykk- og endetarms kreft (CRC). I dette prosjektet fokuseres på betydningen av systemisk tumor-assosiert ...

    • Risk assessment and antibody responses to SARS-CoV-2 in healthcare workers 

      Bansal, Amit; Trieu, Mai Chi; Mohn, Kristin Greve-Isdahl; Madsen, Anders; Olofsson, Jan Stefan; Sandnes, Helene Heitmann; Sævik, Marianne; Søyland, Hanne; Hansen, Lena; Onyango, Therese Bredholt; Tøndel, Camilla; Brokstad, Karl Albert; Syre, Heidi; Riis, Åse Garløv; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)
      Background: Preventing infection in healthcare workers (HCWs) is crucial for protecting healthcare systems during the COVID-19 pandemic. Here, we investigated the seroepidemiology of SARS-CoV-2 in HCWs in Norway with ...

    • Differences in white blood cell proportions between schizophrenia cases and controls are influenced by medication and variations in time of day 

      Villar, Jonelle Marie Dickow; Stavrum, Anne-Kristin Støbakk; Nery Spindola, Leticia Maria; Torsvik, Anja; Bjella, Thomas; Steen, Nils Eiel; Djurovic, Srdjan; Andreassen, Ole; Steen, Vidar Martin; Hellard, Stephanie Francoise Claire Le (Journal article; Peer reviewed, 2023)
      Cases with schizophrenia (SCZ) and healthy controls show differences in white blood cell (WBC) counts and blood inflammation markers. Here, we investigate whether time of blood draw and treatment with psychiatric medications ...

    • Primary sclerosing cholangitis: Surrogate markers of natural history, disease severity, and prognosis 

      Fossdal, Guri (Doctoral thesis, 2023-12-01)
      Sammendrag Bakgrunn: Primær skleroserende kolangitt (PSC) er en immunrelatert leversykdom av ukjent årsak som karakteriseres av kolestase, inflammasjon og strikturer i galletreet og vanligvis utvikler seg til generell ...

    • Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in patients with severe asthma eligible for both 

      Pfeffer, Paul E.; Ali, Nasloon; Murray, Ruth; Ulrik, Charlotte; Tran, Trung N.; Maspero, Jorge; Peters, Matthew; Christoff, George C.; Sadatsafavi, Mohsen; Torres-Duque, Carlos A.; Altraja, Alan; Lehtimäki, Lauri; Papadopoulos, Nikolaos G.; Salvi, Sundeep; Costello, Richard W.; Cushen, Breda; Heffler, Enrico; Iwanaga, Takashi; Al-Ahmad, Mona; Larenas-Linnemann, Désirée; Kuna, Piotr; Fonseca, João A; Al-Lehebi, Riyad; Rhee, Chin Kook; Perez-de-Llano, Luis; Perng Steve, Diahn-Warng; Mahboub, Bassam; Wang, Eileen; Goh, Celine; Lyu, Juntao; Newell, Anthony; Alacqua, Marianna; Belevskiy, Andrey S.; Bhutani, Mohit; Bjermer, Leif Hilding; Bjornsdottir, Unnur; Bourdin, Arnaud; Bulow, Anna von; Busby, John; Canonica, Giorgio Walter; Cosio, Borja G.; Dorscheid, Delbert R.; Muñoz-Esquerre, Mariana; FitzGerald, J. Mark; Gil, Esther Garcia; Gibson, Peter G.; Heaney, Liam G.; Hew, Mark; Hilberg, Ole; Hoyte, Flavia; Jackson, David J.; Koh, Mariko Siyue; Ko, Hsin-Kuo Bruce; Lee, Jae Ha; Lehmann, Sverre; Chaves Loureiro, Cláudia; Lúðvíksdóttir, Dóra; Menzies-Gow, Andrew N.; Mitchell, Patrick; Papaioannou, Andriana I.; Popov, Todor A.; Porsbjerg, Celeste M.; Salameh, Laila; Sirena, Concetta; Taillé, Camille; Taube, Christian; Tohda, Yuji; Wechsler, Michael E.; Price, David B. (Journal article; Peer reviewed, 2023)
      Background: Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult patients ...

    • CACNA1D overexpression and voltage-gated calcium channels in prostate cancer during androgen deprivation 

      McKerr, Niamh; Mohd-Sarip, Adone; Dorrian, Hannah; Breen, Conor; A. James, Jacqueline; McQuaid, Stephen; Mills, Ian Geoffrey; McCloskey, Karen D. (Journal article; Peer reviewed, 2023)
      Prostate cancer is often treated by perturbing androgen receptor signalling. CACNA1D, encoding CaV1.3 ion channels is upregulated in prostate cancer. Here we show how hormone therapy affects CACNA1D expression and CaV1.3 ...

    • Increased Plasma Levels of Triglyceride-Enriched Lipoproteins Associate with Systemic Inflammation, Lipopolysaccharides, and Gut Dysbiosis in Common Variable Immunodeficiency 

      Macpherson, Magnhild Eide; Skarpengland, Tonje; Hov, Johannes Espolin Roksund; Ranheim, Trine; Vestad, Beate; Dahl, Tuva Børresdatter; Fraz, Mai Sasaki Aanensen; Michelsen, Annika Elisabet; Holven, Kirsten Bjørklund; Fevang, Børre; Berge, Rolf Kristian; Aukrust, Pål; Halvorsen, Bente; Jørgensen, Silje Fjellgård (Journal article; Peer reviewed, 2023)
      Purpose: Triglycerides (TG) and their major transport lipoprotein in the circulation (VLDL) appear to be related to inflammation. Patients with common variable immunodeficiency (CVID) have inflammatory complications ...

    • Food hypersensitivity: an examination of factors influencing symptoms and temporal changes in the prevalence of sensitization in an adult sample 

      Lam, Holly C. Y.; Neukirch, Catherine; Janson, Christer; Garcia-Aymerich, Judith; Clausen, Michael; Idrose, N. Sabrina; Demoly, Pascal; Bertelsen, Randi Jacobsen; Ruiz, Lidia C.; Raherison, Chantal; Jarvis, Deborah L. (Journal article; Peer reviewed, 2023)
      Background/Objectives: Food hypersensitivity (FHS) is common, but little is known about the factors associated with severe reactions, age of onset and whether sensitization persists. This study examines the factors associated ...

    • Antibody-mediated interferences affecting cardiac troponin assays: recommendations from the IFCC Committee on Clinical Applications of Cardiac Biomarkers 

      Hammarsten, Ola; Warner, Janet V.; Lam, Leo; Kavsak, Peter; Lindahl, Bertil; Aakre, Kristin Moberg; Collinson, Paul; Jaffe, Allan S.; Saenger, Amy K.; Body, Richard; Mills, Nicholas L.; Omland, Torbjørn; Ordonez-Llanos, Jordi; Apple, Fred S. (Journal article; Peer reviewed, 2023)
      The International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB) provides educational documents to facilitate the interpretation and use of cardiac biomarkers in ...

    • Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis 

      Woldeyohannes, Markos Tesfaye; Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Rahman, Zillur; Bahrami, Shahram; Lin, Aihua; Holen, Børge; Parker, Nadine; Cheng, Weiqiu; Rødevand, Linn; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Smeland, Olav Bjerkehagen; O’Connell, Kevin S.; Andreassen, Ole (Journal article; Peer reviewed, 2023-08-01)
      Background: Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of ...