Browsing Faculty of Medicine by Title
Now showing items 2251-2270 of 8853
-
Doping knowledge, attitudes, and practices of Ugandan athletes': A cross-sectional study
(Peer reviewed; Journal article, 2015-09-22)Background. Despite the development of advanced drug testing systems, both deliberate and inadvertent doping in sports is increasing in elite, amateur and school sports. As a result, alternative approaches that seek to ... -
Dose Constraints for important Organs at Risk in the Head and Neck Region for Carbon Ion Radiotherapy optimized with the Local Effect Model I (LEM I)
(Doctoral thesis, 2021-03-25)Carbon ion radiotherapy (CIRT) exhibits higher relative biological effectiveness (RBE), compared to photon and proton RT. However, there are substantial uncertainties regarding the clinical RBE of carbon ions. Therefore, ... -
Dose- and time-dependent effects of triethylene glycol dimethacrylate on the proteome of human THP-1 monocytes
(Journal article; Peer reviewed, 2018)Triethylene glycol dimethacrylate (TEGDMA) is commonly used in polymer resin-based dental materials. This study investigated the molecular mechanisms of TEGDMA toxicity by identifying its time- and dose-dependent effects ... -
Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort
(Journal article; Peer reviewed, 2022)Lithium is the first-line treatment for bipolar disorder (BD), but there is a large variation in response rate and adverse effects. Although the molecular effects of lithium have been studied extensively, the specific ... -
DOTS improves treatment outcomes and service coverage for tuberculosis in South Ethiopia: a retrospective trend analysis
(Peer reviewed; Journal article, 2005-06-06)Background: DOTS as a strategy was introduced to the tuberculosis control programme in Southern region of Ethiopia in 1996. The impact of the programme on treatment outcomes and the trend in the service coverage for ... -
Double paternal uniparental isodisomy 7 and 15 presenting with Beckwith–Wiedemann spectrum features
(Journal article; Peer reviewed, 2021)Here we describe for the first time double paternal uniparental isodisomy (iUPD) 7 and 15 in a baby boy with features in the Beckwith–Wiedemann syndrome spectrum (BWSp) (placentomegaly, hyperinsulinism, enlarged viscera, ... -
Double-vs single-balloon catheter for induction of labor: Systematic review and individual participant data meta-analysis
(Journal article; Peer reviewed, 2023)Introduction Evidence comparing double-balloon vs single-balloon catheter for induction of labor is divided. We aim to compare the efficacy and safety of double-vs single-balloon catheters using individual participant ... -
Dramatic and sustained increase in HIV-testing rates among antenatal attendees in Eastern Uganda after a policy change from voluntary counselling and testing to routine counselling and testing for HIV: a retrospective analysis of hospital records, 2002-2009
(Peer reviewed; Journal article, 2010-10-14)Background The burden of mother-to-child transmission of HIV in Uganda is high. The aim of this paper is to describe the experience of the first 7 years of the prevention of mother- to- child transmission of HIV (PMTCT) ... -
Drivers of successful implementation of integrated care for multi-morbidity: Mechanisms identified in 17 case studies from 8 European countries
(Journal article; Peer reviewed, 2021)This paper provides a deeper understanding of the mechanisms underlying implementation strategies for integrated care. As part of the SELFIE project, 17 integrated care programmes addressing multi-morbidity from eight ... -
Drug adherence in patient group with Parkinson's disease
(Master thesis, 2018-06-29)Background Patients with Parkinson’s disease needs medicines administered frequently to manage their condition and maintain their quality of life. Poor medicine adherence may influence health negatively, and cause an ... -
Drug delivery in pancreatic cancer : Quantitative studies of gemcitabine and sonoporation in patients and cell line models
(Doctoral thesis, 2020-03-06)Background Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to late stage diagnosis and unresponsiveness to chemotherapies. A dense desmoplastic tumour stroma is considered to represent a barrier against ... -
Drug information in pregnancy. Attitudes and needs among pregnant women and physicians
(Doctoral thesis, 2013-10-25)Background: Drug use in pregnancy is common and both pregnant women and their physicians are in need of appropriate information for decision-making regarding drug therapy. However, uncertainty about the risks of drug use ... -
Drug prescribing quality for older patients. Explicit indicators and multidisciplinary medication reviews
(Doctoral thesis, 2012-03-16)This thesis is based on three published papers that illuminate different aspects of prescribing quality and drug use in older patients who receive home nursing services or live in nursing homes. Persons older than 65 years ... -
Drug seller adherence to clinical protocols with integrated management of malaria, pneumonia and diarrhoea at drug shops in Uganda
(Peer reviewed; Journal article, 2015-07-16)Background: Drug shops are usually the first source of care for febrile children in Uganda although the quality of care they provide is known to be poor. Within a larger quasi-experimental study introducing the WHO/UNICEF ... -
Drug shops in integrated community case management of malaria, pneumonia and diarrhoea in Uganda: Appropriateness of care and adherence to treatment guidelines
(Doctoral thesis, 2016-02-09)Introduction. Private drug shops are an important source of care for children in sub-Saharan Africa, with about half of sick children seeking care at this level. However, these drug shops receive minimal regulation and ... -
Drug treatment at the end of life: An epidemiologic study in nursing homes
(Peer reviewed; Journal article, 2014)Objective. To examine drug treatment in nursing home patients at the end of life, and identify predictors of palliative drug therapy. Design. A historical cohort study. Setting. Three urban nursing homes in Norway. Subjects. ... -
Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs
(Peer reviewed; Journal article, 2006-10-20)Background: The etiology of schizophrenia is unknown, but neurodevelopmental disturbances, myelin- and oligodendrocyte abnormalities and synaptic dysfunction have been suggested as pathophysiological factors in this severe ... -
Druggable genome in attention deficit/hyperactivity disorder and its co-morbid conditions. New avenues for treatment.
(Peer reviewed; Journal article, 2019)Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder with only symptomatic care available. Genome-wide association (GWA) studies can provide a starting point in the search for novel drug ... -
DrugPred_RNA—A Tool for Structure-Based Druggability Predictions for RNA Binding Sites
(Journal article; Peer reviewed, 2021)RNA is an emerging target for drug discovery. However, like for proteins, not all RNA binding sites are equally suited to be addressed with conventional drug-like ligands. To this end, we have developed the structure-based ... -
Drusenoid pigment epithelial detachment volume is associated with a decrease in best-corrected visual acuity and central retinal thickness: the Norwegian Pigment Epithelial Detachment Study (NORPED) report no. 1
(Journal article; Peer reviewed, 2020)Purpose To investigate the association of drusenoid pigment epithelial detachment (DPED) volume and change in best‐corrected visual acuity (BCVA) and central retinal thickness (CRT) during the growth phase of large ...