Browsing Faculty of Medicine by Title
Now showing items 5508-5527 of 8877
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Molecular mechanisms of mitochondrial dysfunction in neurodegenerative diseases
(Doctoral thesis, 2024-06-05)Bakgrunn Nevrodegenerative lidelser er komplekse lidelser i sentralnervesystemet som er typisk preget av akkumulering av feilfoldede proteiner og progressiv degenerasjon og død av sårbare cellepopulasjoner i de berørte ... -
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
(Peer reviewed; Journal article, 2014-05-21)Background: The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have ... -
Molecular mechanisms of sonoporation in cancer therapy : Optimization of sonoporation parameters and investigations of intracellular signalling
(Doctoral thesis, 2020-06-17)Background: Sonoporation, which is treatment with ultrasound (US) and microbubbles (MB), has shown great potential for enhancing the therapeutic efficacy of chemotherapy in cancer therapy. However, there is still very ... -
Molecular pathogenesis of polymerase gamma-related neurodegeneration
(Peer reviewed; Journal article, 2014-07)Objective: Polymerase gamma (POLG) mutations are a common cause of mitochondrial disease and have also been linked to neurodegeneration and aging. We studied the molecular mechanisms underlying POLG-related neurodegeneration ... -
Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
(Journal article, 2021)Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive heterogeneity in disease presentation between patients, which is likely due to an underlying molecular diversity. Here, we aimed at ... -
Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer
(Peer reviewed; Journal article, 2014-09-27)Background: About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk with unfavorable prognosis. In the framework of the European Network for Individualized Treatment in EC (ENITEC), we ... -
Molecular structure and function of myelin protein P0 in membrane stacking
(Peer reviewed; Journal article, 2019)Compact myelin forms the basis of nerve insulation essential for higher vertebrates. Dozens of myelin membrane bilayers undergo tight stacking, and in the peripheral nervous system, this is partially enabled by myelin ... -
Molecular subtypes in stage II-III colon cancer defined by genomic instability: Early recurrence-risk associated with a high copy-number variation and loss of RUNX3 and CDKN2A
(Peer reviewed; Journal article, 2015-04-16)Objective: We sought to investigate various molecular subtypes defined by genomic instability that may be related to early death and recurrence in colon cancer. Methods: We sought to investigate various molecular subtypes ... -
Molecular Subtypes of Breast Cancer: Long-term Incidence Trends and Prognostic Differences
(Peer reviewed; Journal article, 2016-12)Background: Secular trends in incidence and prognosis of molecular breast cancer subtypes are poorly described. We studied long-term trends in a population of Norwegian women born 1886–1977. Methods: A total of 52,949 women ... -
Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients
(Peer reviewed; Journal article, 2013-08)Molecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. However, its clinical significance remains to be established. In this study, the main aims were to discover ... -
Monitoring activities in out-of-hours emergency primary care in Norway. A special emphasis on nurses telephone triage and counselling
(Doctoral thesis, 2011-11-18)The main aim of this thesis has been to develop and establish an organisation, the Watchtowers, in order to continuously collect valid data from the OOH services in Norway, and to describe the activities. Further, we have ... -
Monitoring children and adolescents with severe obesity: body mass index (BMI), BMI z‐score or percentage above the International Obesity Task Force overweight cut‐off?
(Peer reviewed; Journal article, 2019)Aim: Body mass index (BMI) metrics are widely used as a proxy for adiposity in children with severe obesity. The BMI expressed as the percentage of a cut‐off percentile for overweight or obesity has been proposed as a ... -
Monitoring multiple myeloma by quantification of recurrent mutations in serum
(Peer reviewed; Journal article, 2017)Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple myeloma patients and its relation to disease activity during long-term ... -
Monoamine synthesis in neurometabolic disorders affecting catecholaminergic functioning: biochemical mechanisms and treatment implications
(Doctoral thesis, 2024-02-14)Løpet av de siste 100 år er det oppdaget hundrevis av arvelige metabolske forstyrrelser. Slike tilstander har ofte recessiv Mendelsk arv og kalles også medfødte metabolismefeil. Symptomene debuterer vanligvis like etter ... -
The monocyte system in haematological malignancies
(Doctoral thesis, 2020-04-17)Monocytes consist of classical, intermediate, and non-classical monocytes. In haematological malignancies, such as multiple myeloma and acute myeloid leukaemia, monocytes are affected by both the disease itself and the ... -
Monocyte-derived dendritic cells in cancer immunotherapy : Considerations on their applicability
(Doctoral thesis, 2021-02-17)Cancer is the leading cause of death in the developed world. While treatment options and detection have improved over the last century, mortality rate remains high especially in metastatic disease. Traditional treatment ... -
Monocytes from neonates and adults have a similar capacity to adapt their cytokine production after previous exposure to BCG and β-glucan
(Journal article; Peer reviewed, 2020-02-21)The Bacillus Calmette-Guérin (BCG) vaccine is administered at birth in tuberculosis (TB) endemic countries. BCG vaccination is also associated with protective non-specific effects against non-tuberculous infections. This ... -
Monogenic diabetes and pancreatic exocrine dysfunction in mouse and man
(Doctoral thesis, 2009-12-04)Exocrine and endocrine pancreatic disease is often observed to occur together. The close colocalization of the endocrine and exocrine tissues within one organ, as well as their common embryological ancestry, have given ... -
Monolithic zirconia crowns in the aesthetic zone in heavy grinders with severe tooth wear – An observational case-series
(Peer reviewed; Journal article, 2018)Objectives The aim of this study was to assess the clinical outcomes and patient satisfaction with monolithic zirconia crowns in patients with severe tooth wear (≥1/3 of the tooth crown) in the aesthetic zone. Methods The ... -
Monolithic zirconia crowns – wall thickness, surface treatment and load at fracture
(Peer reviewed; Journal article, 2019)Purpose: The aim of this study was to evaluate the effect of wall thickness on load at fracture of monolithic zirconia dental crowns after aging. Materials and Methods: Seventy translucent monolithic zirconia crowns (DD ...