Blar i Faculty of Medicine på tittel
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Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study
(Peer reviewed; Journal article, 2019)Lithium has been the first-line treatment for bipolar disorder (BD) for more than six decades. Although the molecular effects of lithium have been studied extensively and gene expression changes are generally believed to ... -
Exploring protocol bias in airway microbiome studies: one versus two PCR steps and 16S rRNA gene region V3 V4 versus V4
(Journal article; Peer reviewed, 2021)Background Studies on the airway microbiome have been performed using a wide range of laboratory protocols for high-throughput sequencing of the bacterial 16S ribosomal RNA (16S rRNA) gene. We sought to determine the ... -
Exploring the anti-leukemic effect of the combination treatment with Valproic acid, Lonidamine and Mycophenolate mofetil in acute myeloid leukemia
(Master thesis, 2015-06-01)An accumulation of immature myeloid progenitor cells at the expense of normal hematopoietic precursors characterizes the aggressive heterogeneous cancer acute myeloid leukemia (AML). It affects the bone marrow and peripheral ... -
Exploring the boundaries of precision haemato-oncology : The case of FLT3 length mutated acute myeloid leukaemia
(Doctoral thesis, 2020-02-14)This dissertation explores the astounding biological heterogeneity of acute myeloid leukaemia (AML). In three research papers, we study FLT3 length mutated (LM) AML to contribute to the characterisation of genetic diversity ... -
Exploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: the EBBA-Life study
(Journal article; Peer reviewed, 2020)Purpose Whether an unfavorable lifestyle not only affects breast cancer risk, but also influences age at onset of breast cancer and survival, is under debate. Methods In a population-based cohort, the Energy Balance ... -
Exploring the genetic contribution to idiopathic Parkinson disease
(Doctoral thesis, 2021-03-05)Background: Parkinson disease (PD) is a major cause of death and disability and has a devastating global socioeconomic impact. It affects 1-2% of the population above the age of 65 and its prevalence increases as the ... -
Exploring the human plasma proteome for humoral mediators of remote ischemic preconditioning - A word of caution
(Peer reviewed; Journal article, 2014-10-15)Despite major advances in early revascularization techniques, cardiovascular diseases are still the leading cause of death worldwide, and myocardial infarctions contribute heavily to this. Over the past decades, it has ... -
Exploring the IBS Brain: Resting State Functional Connectivity and Machine Learning
(Master thesis, 2019-06-28) -
Exploring the Patient Perspective of Bone Sarcoma Survivors Who Have Undergone Particle Radiotherapy Abroad
(Journal article; Peer reviewed, 2023)Background/Aim: Sarcoma patients’ experiences of their health-related quality of life and late effects following particle therapy are sparse. Such knowledge is essential to optimize treatment compliance and follow-up care ... -
Exploring the potential of public proteomics data
(Peer reviewed; Journal article, 2016)In a global effort for scientific transparency, it has become feasible and good practice to share experimental data supporting novel findings. Consequently, the amount of publicly available MS‐based proteomics data has ... -
Exploring the relationship between coronary heart disease and type 2 diabetes: a cross-sectional study of secondary prevention among diabetes patients
(Peer reviewed; Journal article, 2019)Background: Coronary heart disease (CHD) and stroke are the major causes of death among people with diabetes. Aim: To describe the prevalence and onset of CHD and stroke among patients with type 2 diabetes mellitus (T2DM) ... -
Exploring the relationship between physical activity, life goals and health-related quality of life among high school students: a cross-sectional study
(Peer reviewed; Journal article, 2016-08-03)Background: Two models were developed to increase high school students’ participation in physical education (PE): “motion enjoyment” and “sport enjoyment”. The first model focuses on increasing knowledge about the health ... -
Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder
(Peer reviewed; Journal article, 2018)The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders with ... -
Exploring uncertainty and use of real-world data in the National Institute for Health and Care Excellence single technology appraisals of targeted cancer therapy
(Journal article; Peer reviewed, 2022)Objectives Dealing with uncertainty is one of the critical topics in health technology assessment. The greater decision uncertainty in appraisals, the less clear the clinical- and cost-effectiveness of the health technology. ... -
Exploring variables affecting sense of coherence and social support in recovery after colorectal cancer surgery among the oldest old
(Journal article; Peer reviewed, 2022)Objective To explore the associations between sense of coherence, perceived social support, and demographic and clinical characteristics among survivors ≥80 years treated for curable colorectal cancer. Methods This ... -
Exponerat bildfält vid analog respektive digital röntgenteknik
(Master thesis, 2009-05-14)Background: Digital x-ray technique has made it possible to hide insufficient collimation of the irradiated field by electronic demarcation of the visible part of the image. This could impact on radiographer's motivation ... -
The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?
(Journal article; Peer reviewed, 2021)Emerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering ... -
Exposure to Air Pollution during Pregnancy and Childhood, and White Matter Microstructure in Preadolescents
(Journal article; Peer reviewed, 2020)Background: Air pollution has been related to brain structural alterations, but a relationship with white matter microstructure is unclear. Objectives: We assessed whether pregnancy and childhood exposures to air ... -
Exposure to Antibacterial Chemicals Is Associated With Altered Composition of Oral Microbiome
(Journal article; Peer reviewed, 2022)Antimicrobial chemicals are used as preservatives in cosmetics, pharmaceuticals, and food to prevent the growth of bacteria and fungi in the products. Unintentional exposure in humans to such chemicals is well documented, ...