Blar i Faculty of Medicine på tittel

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    • Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines 

      Acuña-Hinrichsen, Francisca; Covarrubias-Pinto, Adriana; Ishizuka, Yuta; Stolzenbach, María Francisca; Martin, Carolina; Salazar, Paula; Castro, Maite A.; Bramham, Clive Raymond Evjen; Otth, Carola (Journal article; Peer reviewed, 2021)
      Herpes simplex virus type 1 (HSV-1) is a widespread neurotropic virus. Primary infection of HSV-1 in facial epithelium leads to retrograde axonal transport to the central nervous system (CNS) where it establishes latency. ...

    • Herpesviral interactomics. Intraviral and virus-host protein-protein interaction network from different species of herpesviruses 

      Fossum, Even (Doctoral thesis, 2008-02-01)

    • Herring roe oil in treatment of psoriasis – influence on immune cells and cytokine network 

      Petrovic, Aleksandra; Bueide, Ingvild Øye; Tveit, Kåre Steinar; Hallaråker, Hogne; Bjørndal, Bodil; Holmes, Timothy Dunstan; Davies, Richard Allan; Brokstad, Karl Albert; Bergum, Brith; Appel, Silke (Journal article; Peer reviewed, 2023)
      Background: Psoriasis is a chronic immune-mediated skin disease with systemic inflammation and comorbidities. Although the disease severity may vary over time, many patients suffer from mild to moderate disease. Often local ...

    • Heterogeneity of patient-derived acute myeloid leukemia cells subjected to SYK in vitro inhibition 

      Brattås, Marte Karen; Hemsing, Anette Lodvir; Rye, Kristin Paulsen; Hatfield, Kimberley Joanne; Reikvam, Håkon (Journal article; Peer reviewed, 2022)
      Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a dismal prognosis. The cytoplasmic spleen tyrosine kinase (SYK) is highly expressed by hematopoietic cells and has emerged as a potential therapeutic ...

    • Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight 

      Iurilli, Maria Laura Caminia; Zhou, Bin; Bennett, James E.; Carrillo-Larco, Rodrigo M.; Sophiea, Marisa K.; Rodriguez-Martinez, Andrea; Bixby, Honor; Solomon, Bethlehem D.; Taddei, Cristina; Danaei, Goodarz; Di Cesare, Mariachiara; Stevens, Gretchen A.; Riley, Leanne M.; Savin, Stefan; Cowan, Melanie J.; Bovet, Pascal; Damasceno, Albertino Antonio Moura; Chirita-Emandi, Adela; Hayes, Alison J; Ikeda, Nayu; Jackson, Rod T.; Khang, Young-Ho; Laxmaiah, Avula; Liu, Jing; Miranda, J. Jaime; Saidi, Olfa; Sebert, Sylvain; Sorić, Maroje; Starc, Gregor; Gregg, Edward W.; Abarca-Gómez, Leandra; Abdeen, Ziad A.; Abdrakhmanova, Shynar; Ghaffar, Suhaila Abdul; Rahim, Hanan Abdul; Abu-Rmeileh, Niveen M.; Garba, Jamila Abubakar; Acosta-Cazares, Benjamin; Adams, Robert J.; Aekplakorn, Wichai; Afsana, Kaosar; Afzal, Shoaib; Agdeppa, Imelda A.; Aghazadeh-Attari, Javad; Aguilar-Salinas, Carlos A.; Agyemang, Charles; Ahmad, Mohamad Hasnan; Ahmad, Noor Ani; Ahmadi, Ali; Ahmadi, Naser; Hassan, Soheir; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ariansen, Inger Kristine Holtermann; Bergh, Ingunn Holden; Bjertness, Espen; Bjertness, Marius Bergsmark; Ekelund, Ulf; Graff-Iversen, Sidsel; Grøholt, Else Karin; Haugsgjerd, Teresa Risan; Janszky, Imre; Kolle, Elin; Krokstad, Steinar; Madar, Ahmed Ali; Mathiesen, Ellisiv B.; Meisfjord, Jørgen Rajan; Meyer, Haakon Eduard; Sen, Abhijit; Skodje, Gry Irene; Sørgjerd, Elin Pettersen; Sparboe-Nilsen, Bente; Steene-Johannessen, Jostein; Tarp, Jakob; Tell, Grethe S.; Torheim, Liv Elin; Wilsgaard, Tom (Journal article; Peer reviewed, 2021)
      From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated ...

    • Hfe genotype, ferritin levels and transferrin saturation in patients with suspected hereditary hemochromatosis 

      Sandnes, Miriam; Vorland, Marta; Ulvik, Rune J.; Reikvam, Håkon (Journal article; Peer reviewed, 2021)
      HFE hemochromatosis is characterized by increased iron absorption and iron overload due to variants of the iron-regulating HFE gene. Overt disease is mainly associated with homozygosity for the C282Y variant, although the ...

    • HIDEA syndrome is caused by biallelic, pathogenic, rare or founder P4HTM variants impacting the active site or the overall stability of the P4H-TM protein 

      Kraatari-Tiri, Minna; Soikkonen, Leila; Myllykoski, Matti Aukusti; Jamshidi, Yalda; Karimiani, Ehsan G.; Komulainen-Ebrahim, Jonna; Kallankari, Hanna; Mignot, Cyril; Depienne, Christel; Keren, Boris; Nougues, Marie-Christine; Alsahlawi, Zahra; Romito, Antonio; Martini, Javier; Toosi, Mehran B.; Carroll, Christopher J.; Tripolszki, Kornelia; Bauer, Peter; Uusimaa, Johanna; Bertoli-Avella, Aida M.; Koivunen, Peppi; Rahikkala, Elisa (Journal article; Peer reviewed, 2022)
      HIDEA syndrome is caused by biallelic pathogenic variants in P4HTM. The phenotype is characterized by muscular and central hypotonia, hypoventilation including obstructive and central sleep apneas, intellectual disability, ...

    • A hierarchical frailty model applied to two-generation melanoma data 

      Moger, Tron Anders; Haugen, Marion; Yip, Benjamin H. K.; Gjessing, Håkon K.; Borgan, Ørnulf (Peer reviewed; Journal article, 2010)
      We present a hierarchical frailty model based on distributions derived from non-negative Lévy processes. The model may be applied to data with several levels of dependence, such as family data or other general clusters, ...

    • High accuracy mass spectrometry analysis as a tool to verify and improve gene annotation using Mycobacterium tuberculosis as an example 

      De Souza, Gustavo A.; Målen, Hiwa; Søfteland, Tina; Sælensminde, Gisle; Prasad, Swati; Jonassen, Inge; Wiker, Harald G. (Peer reviewed; Journal article, 2008-07-02)
      Background: While the genomic annotations of diverse lineages of the Mycobacterium tuberculosis complex are available, divergences between gene prediction methods are still a challenge for unbiased protein dataset generation. ...

    • High attrition among HIV-infected patients with advanced disease treated in an intermediary referral center in Maputo, Mozambique 

      Molfino, Lucas; Kumar, Ajay M.V.; Isaakidis, Petros; Van den Bergh, Rafael; Khogali, Mohamed; Hinderaker, Sven Gudmund; Magaia, Alice; Lobo, Sheila; Edwards, Celeste Gracia; Walter, Jan (Peer reviewed; Journal article, 2014-04-08)
      Background: In Mozambique, antiretroviral therapy (ART) scale-up has been successfully implemented. However, attrition in care remains a major programmatic challenge. In 2009, an intermediary-level HIV referral center was ...

    • High birth weight and perinatal mortality among siblings. A register based study in Norway, 1967-2011 

      Kristensen, Petter; Keyes, Katherine M.; Susser, Ezra; Corbett, Karina; Mehlum, Ingrid Sivesind; Irgens, Lorentz M. (Peer reviewed; Journal article, 2017-02-28)
      Background: Perinatal mortality according to birth weight has an inverse J-pattern. Our aim was to estimate the influence of familial factors on this pattern, applying a cohort sibling design. We focused on excess mortality ...

    • High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer 

      Mauland, Karen Klepsland; Trovik, Jone; Wik, Elisabeth; Ræder, Maria B.; Njølstad, Tormund Salvesen; Stefansson, Ingunn Marie; Øyan, Anne Margrete; Kalland, Karl-Henning; Bjørge, Tone; Akslen, Lars A.; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2011)
      Background: Endometrial cancer incidence is increasing in industrialised countries. High body mass index (BMI, kg m−2) is associated with higher risk for disease. We wanted to investigate if BMI is related to clinico-pathological ...

    • The high burden of infant deaths in rural Burkina Faso: a prospective community-based cohort study 

      Diallo, Abdoulaye Hama; Meda, Nicolas; Sommerfelt, Halvor; Traore, Germain S.; Cousens, Simon; Tylleskär, Thorkild (Peer reviewed; Journal article, 2012-09-05)
      Background: Infant mortality rates (IMR) remain high in many sub-Saharan African countries, especially in rural settings where access to health services may be limited. Studies in such communities can provide relevant data ...

    • High Burden of Neurodevelopmental Delay among Children Born to Women with Obstructed Labour in Eastern Uganda: A Cohort Study 

      Chebet, Martin; Musaba, Milton W.; Mukunya, David; Makoko, Brian; Napyo, Agnes Kasede; Nantale, Ritah; Auma, Proscovia; Atim, Ketty; Nahurira, Doreck; Lee, Seungwon; Okello, Dedan; Ssegawa, Lawrence; Bromley, Kieran; Burgoine, Kathy; Ndeezi, Grace; Tumwine, James K; Wandabwa, Julius; Kiguli, Sarah (Journal article; Peer reviewed, 2023)
      Over 250 million infants in low and middle-income countries do not fulfill their neurodevelopment potential. In this study, we assessed the incidence and risk factors for neurodevelopmental delay (NDD) among children born ...

    • High cardiac background activity limits 99mTc-MIBI radioguided surgery in aortopulmonary window parathyroid adenomas 

      Schwarzlmüller, Thomas; Brauckhoff, Katrin; Løvås, Kristian; Biermann, Martin; Brauckhoff, Michael (Peer reviewed; Journal article, 2014-04-23)
      Background: Radioguided surgery using 99m-Technetium-methoxyisobutylisonitrile (99mTc-MIBI) has been recommended for the surgical treatment of mediastinal parathyroid adenomas. However, high myocardial 99mTc-MIBI uptake ...

    • High circulating levels of the homeostatic chemokines CCL19 and CCL21 predict mortality and disease severity in Covid-19 

      Tveita, Anders Aune; Murphy, Sarah Louise Mikalsen; Holter, Jan Cato; Kildal, Anders Benjamin; Michelsen, Annika Elisabet; Lerum, Tøri Vigeland; Kaarbø, Mari; Heggelund, Lars; Holten, Aleksander Rygh; Finbråten, Ane-Kristine; Muller, Karl Erik; Mathiessen, Alexander; Bøe, Simen; Fevang, Børre; Granerud, Beathe Kiland; Tonby, Kristian; Lind, Andreas; Dudman, Susanne; Nezvalova-Henriksen, Katerina; Müller, Fredrik; Skjønsberg, Ole Henning; Trøseid, Marius; Barratt-Due, Andreas; Riise, Anne Margarita Dyrhol; Aukrust, Pål; Halvorsen, Bente Evy; Dahl, Tuva Børresdatter; Ueland, Thor (Journal article; Peer reviewed, 2022)
      Background Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators of tissue inflammation, but ...

    • A high confidence, manually validated human blood plasma protein reference set 

      Schenk, Susann; Schoenhals, Gary J.; De Souza, Gustavo A.; Mann, Matthias (Peer reviewed; Journal article, 2008-09-15)
      Background: The immense diagnostic potential of human plasma has prompted great interest and effort in cataloging its contents, exemplified by the Human Proteome Organization (HUPO) Plasma Proteome Project (PPP) pilot ...

    • High Constitutive Cytokine Release by Primary Human Acute Myeloid Leukemia Cells Is Associated with a Specific Intercellular Communication Phenotype 

      Reikvam, Håkon; Aasebø, Elise; Brenner, Annette; Bartaula-Brevik, Sushma; Grønningsæter, Ida Sofie; Forthun, Rakel Brendsdal; Hovland, Randi; Bruserud, Øystein (Peer reviewed; Journal article, 2019-07-04)
      Acute myeloid leukemia (AML) is a heterogeneous disease, and this heterogeneity includes the capacity of constitutive release of extracellular soluble mediators by AML cells. We investigated whether this capacity is ...

    • High degree of heterogeneity of PD-L1 and PD-1 from primary to metastatic endometrial cancer 

      Engerud, Hilde Renate; Berg, Hege Fredriksen; Myrvold, Madeleine; Halle, Mari Kyllesø; Bjørge, Line; Haldorsen, Ingfrid S.; Høivik, Erling Andre; Trovik, Jone; Krakstad, Camilla (Journal article; Peer reviewed, 2020)
      Objective PD-L1 and PD-1 are predictive markers for immunotherapy and increasingly relevant in endometrial cancer. The reported fraction of positive primary tumors has been inconsistent. We investigated the expression of ...

    • High expression of miR‑17‑5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients 

      Støen, Maria Jenvin; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona Irene; Ingebriktsen, Lise Martine; Bremnes, Roy M.; Dønnem, Tom; Lombardi, Ana Paola; Kilvær, Thomas Karsten; Rasmussen Busund, Lill-Tove; Richardsen, Elin (Journal article; Peer reviewed, 2021)
      MicroRNAs (miRs) are small non-coding RNA molecules, which are involved in the development of various malignancies, including prostate cancer (PCa). miR-17-5p is considered the most prominent member of the miR-17-92 cluster, ...