Blar i Faculty of Medicine på tittel
Viser treff 5768-5787 av 8878
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A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology
(Peer reviewed; Journal article, 2015-11-24)Changes in mitochondrial amount and shape are intimately linked to maintenance of cell homeostasis via adaptation of vital functions. Here, we developed a new live-cell reporter strategy to simultaneously monitor mitochondrial ... -
A New Look at the Functional Organization of the Golgi Ribbon
(Peer reviewed; Journal article, 2019-08-21)A characteristic feature of vertebrate cells is a Golgi ribbon consisting of multiple cisternal stacks connected into a single-copy organelle next to the centrosome. Despite numerous studies, the mechanisms that link the ... -
A New Method for Isolation of Interstitial Fluid from Human Solid Tumors Applied to Proteomic Analysis of Ovarian Carcinoma Tissue
(Peer reviewed; Journal article, 2011-04-26)Major efforts have been invested in the identification of cancer biomarkers in plasma, but the extraordinary dynamic range in protein composition, and the dilution of disease specific proteins make discovery in plasma ... -
New methods clear the dust off old biopsies. RNA sequencing of FFPE kidney biopsies
(Doctoral thesis, 2019-06-07)Background and aims: Formalin-fixed, paraffin-embedded (FFPE) tissues are an underused resource for molecular analyses. We wanted to exploit renal biopsies also on the mRNA level to elucidate pathophysiological mechanisms ... -
A new pathway for elective surgery to reduce cancellation rates
(Peer reviewed; Journal article, 2012-06-11)Background: The cancellation of planned surgeries causes prolonged wait times, harm to patients, and is a waste of scarce resources. To reduce high cancellation rates in a Norwegian general hospital, the pathway for elective ... -
A new pathway for penicillin delabeling in Norway
(Journal article; Peer reviewed, 2023)Background: Penicillin allergy is self-reported by 3–10% of patients admitted to hospital. The label is wrong in 90% of the cases and has severe health implications. Penicillin-delabeling can reverse the negative effects ... -
New procedures for genetic testing and counselling of patients with breast or ovarian cancer
(Doctoral thesis, 2020-05-29)The aim of this PhD project was to evaluate alternative procedures for genetic testing and counselling of patients newly diagnosed with breast or ovarian cancer, in order to meet the expected increasing need of this health ... -
New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells
(Journal article, 2021)Novel chemotherapeutic strategies for acute myeloid leukemia (AML) treatment are called for. We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin (3) and myxin (4) exhibit potent and ... -
New quality regulations versus established nursing home practice: a qualitative study
(Peer reviewed; Journal article, 2012-06-07)Background: Western governments have initiated reforms to improve the quality of care for nursing home residents. Most of these reforms encompass the use of regulations and national quality indicators. In the Norwegian ... -
A New Score for Sharp Discharges in the EEG Predicts Epilepsy
(Journal article; Peer reviewed, 2023)Purpose: A challenge in EEG interpretation is to correctly classify suspicious focal sharp activity as epileptiform or not. A predictive score was developed from morphologic features of the first focal sharp discharge, ... -
A new software tool for computer assisted in vivo high-content analysis of transplanted fluorescent cells in intact zebrafish larvae
(Journal article; Peer reviewed, 2022)Acute myeloid leukemia and myelodysplastic syndromes are cancers of the bone marrow with poor prognosis in frail and older patients. To investigate cancer pathophysiology and therapies, confocal imaging of fluorescent ... -
New strides towards fair processes for financing universal health coverage
(Journal article; Peer reviewed, 2023)Fair processes in health financing decisions should not be undervalued or perceived as secondary to the goals of universal health coverage. By integrating fair-process principles and criteria into health financing decisions, ... -
New therapeutic targets in human acute myeloid leukemia
(Doctoral thesis, 2012-03-16) -
New tools to enhance the detection of post-translational modifications: Development and application of a mass spectrometry-based proteomic software and of specific antibodies detecting propionylated lysines
(Master thesis, 2009-08-02)Mass spectrometry based proteomics has evolved into a powerful tool in characterising proteins and their respective function in the cell. A proteins cellular localisation, concentration and activity is regulated by several ... -
Newborn Care Practices in Northern Uganda : Studies on breastfeeding, decision-making and hypothermia
(Doctoral thesis, 2020-02-13)Background: Early initiation and exclusive breastfeeding reduce neonatal morbidity and mortality. One of the key mechanisms through which optimal breastfeeding reduces neonatal mortality is by reducing neonatal hypothermia. ... -
Newborn health benefits or financial risk protection? An ethical analysis of a real-life dilemma in a setting without universal health coverage
(Peer reviewed; Journal article, 2018)Introduction: High healthcare costs make illness precarious for both patients and their families’ economic situation. Despite the recent focus on the interconnection between health and financial risk at the systemic level, ... -
The Next Influenza Pandemic: Lessons from Hong Kong, 1997
(Peer reviewed; Journal article, 1999)The 1997 Hong Kong outbreak of an avian influenzalike virus, with 18 proven human cases, many severe or fatal, highlighted the challenges of novel influenza viruses. Lessons from this episode can improve international and ... -
Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations
(Journal article; Peer reviewed, 2021)Mitophagy specifically recognizes and removes damaged or superfluous mitochondria to maintain mitochondrial homeostasis and proper neuronal function. Defective mitophagy and the resulting accumulation of damaged mitochondria ... -
Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson's disease
(Journal article; Peer reviewed, 2023)Replenishing nicotinamide adenine dinucleotide (NAD) via supplementation of nicotinamide riboside (NR) has been shown to confer neuroprotective effects in models of aging and neurodegenerative diseases, including Parkinson’s ... -
Night shift work, chemical coexposures and risk of female breast cancer in the Norwegian Offshore Petroleum Workers (NOPW) cohort: a prospectively recruited case-cohort study
(Journal article; Peer reviewed, 2022)Objectives This study examined the association between night shift work and risk of breast cancer, overall and by hormone receptor subtype, among females in the Norwegian Offshore Petroleum Workers (NOPW) cohort. We also ...