Blar i Faculty of Medicine på tittel
Viser treff 5848-5867 av 8878
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The Norwegian Society for Pharmacoepidemiology
(Journal article, 2021) -
The Norwegian Stroke in the Young Study (NOR-SYS): rationale and design
(Peer reviewed; Journal article, 2013-07-17)Background: Ischemic stroke in young adults is a major health problem being associated with a higher vascular morbidity and mortality compared to controls, and a stroke recurrence rate of 25% during the first decade. The ... -
The Norwegian tenecteplase stroke trial (NOR-TEST): randomised controlled trial of tenecteplase vs. alteplase in acute ischaemic stroke
(Peer reviewed; Journal article, 2014-05-15)Background: Alteplase is the only approved thrombolytic agent for acute ischaemic stroke. The overall benefit from alteplase is substantial, but some evidence indicates that alteplase also has negative effects on the ... -
Nosocomial outbreak of neonatal Salmonella enterica serotype Enteritidis meningitis in a rural hospital in northern Tanzania
(Peer reviewed; Journal article, 2007-09-14)Background: Clinicians at Haydom Lutheran Hospital, a rural hospital in northern Tanzania noted an unusually high case-fatality rate of pediatric meningitis and suspected an outbreak of an unknown agent or an organism ... -
Not every estimate counts – evaluation of cell composition estimation approaches in brain bulk tissue data
(Journal article; Peer reviewed, 2023-06-07)Background: Variation in cell composition can dramatically impact analyses in bulk tissue samples. A commonly employed approach to mitigate this issue is to adjust statistical models using estimates of cell abundance derived ... -
Nothing to complain about? : residents’ and relatives’ viewson a "good life" and ethical challenges in nursing homes
(Peer reviewed; Journal article, 2014)Background: Nursing home residents are a vulnerable population. Most of them suffer from multimorbidity, while many have cognitive impairment or dementia and need care around the clock. Several ethical challenges in nursing ... -
A novel 3D PDAC model system developed with the use of decellularized matrix scaffolds
(Master thesis, 2019-06-28) -
Novel adipose genes in substrate- and depot-dependent lipid accumulation
(Doctoral thesis, 2021-06-24)Altered adipose tissue function in obesity is linked to increased risk of type 2 diabetes (T2D) and cardiometabolic diseases via insulin resistance, visceral adiposity, hypertension, and other traits. This thesis studied ... -
A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer
(Journal article; Peer reviewed, 2022)Background and objective Breast cancer (BC) diagnosed at ages <40 years presents with more aggressive tumour phenotypes and poorer clinical outcome compared to older BC patients. Here, we explored transcriptional BC ... -
A novel bicyclic lactone and other polyphenols from the commercially important vegetable Anthriscus cerefolium
(Journal article; Peer reviewed, 2022)Garden chervil, Anthriscus cerefolium (L.) Hoffm. is an important herb commonly applied in Norwegian large-scale commercial kitchens. This species is a highly enriched source of phenolics, containing 1260 mg gallic acid ... -
Novel biomarkers in multiple sclerosis pathology with a focus on neuroprotection and myelin repair
(Doctoral thesis, 2024-01-16)Multippel sklerose (MS) er en sykdom som fører til skade på nervesystemet, kjennetegnet av definerte områder med vevsskade (lesjoner) i sentralnervesystemet (CNS). Dette resulterer i varig funksjonshemming hos pasienter. ... -
A novel case of impaired C-reactive protein response following open-heart surgery: A case report and review of the literature
(Journal article; Peer reviewed, 2021)Background C-reactive protein (CRP) is expected to increase in response to a range of inflammatory stimuli such as infections or extensive tissue trauma. Case report We present a novel case of severely impaired CRP ... -
Novel clearance of muscle proteins by muscle cells
(Journal article; Peer reviewed, 2020)Blood levels of cardiac troponins (cTn) and myoglobin are analysed when myocardial infarction (MI) is suspected. Here we describe a novel clearance mechanism for muscle proteins by muscle cells. The complete plasma clearance ... -
A novel concentrated, interdisciplinary group rehabilitation program for patients with chronic obstructive pulmonary disease: Protocol for a nonrandomized clinical intervention study
(Journal article; Peer reviewed, 2022)Background: Pulmonary rehabilitation has been demonstrated to be a highly effective treatment for people with chronic obstructive pulmonary disease (COPD). However, its availability is scarce worldwide, and new and ... -
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function
(Peer reviewed; Journal article, 2019)Hemophagocytic lymphohistiocytosis (HLH) is characterized by immune dysregulation due to inadequate restraint of overactivated immune cells and is associated with a variable clinical spectrum having overlap with more common ... -
Novel endoscopic and MRI-based methods for evaluating exocrine pancreatic function in pancreatitis and monogenic forms of diabetes
(Doctoral thesis, 2013-11-15)Background: Monogenic diabetes (Maturity onset diabetes in the young, MODY) are autosomal dominantly inherited diabetes syndromes characterized by diabetes due to beta cell dysfunction, with typical onset of diabetes before ... -
A novel fibrosis index comprising a non-cholesterol sterol accurately predicts HCV-related liver cirrhosis
(Peer reviewed; Journal article, 2014-04-03)Diagnosis of liver cirrhosis is essential in the management of chronic hepatitis C virus (HCV) infection. Liver biopsy is invasive and thus entails a risk of complications as well as a potential risk of sampling error. ... -
A novel Geriatric Assessment frailty score predicts two-year mortality after Transcatheter Aortic Valve implantation
(Peer reviewed; Journal article, 2018-10-31)Aims Established surgical scores have limitations in delineating risk among candidates for transcatheter aortic valve implantation (TAVI). Assessment of frailty might help to estimate the mortality risk and identify patients ... -
A novel GFP nude rat model to investigate tumor-stroma interactions
(Peer reviewed; Journal article, 2014-12-21)Backgroud: A key strategy for the study of the tumor microenvironment is to implant human tumor cells in an immunodeficient rodent strain ubiquitously expressing a fluorescent marker. Here, a novel nude rat expressing a ... -
Novel hybridization- and tag-based error-corrected method for sensitive ctDNA mutation detection using ion semiconductor sequencing
(Journal article; Peer reviewed, 2022)Circulating tumor DNA (ctDNA) analysis has emerged as a clinically useful tool for cancer diagnostics and treatment monitoring. However, ctDNA detection is complicated by low DNA concentrations and technical challenges. ...