Blar i Faculty of Medicine på tittel
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A novel nanoprobe for multimodal imaging is effectively incorporated into human melanoma metastatic cell lines
(Peer reviewed; Journal article, 2015-09-08)To facilitate efficient drug delivery to tumor tissue, several nanomaterials have been designed, with combined diagnostic and therapeutic properties. In this work, we carried out fundamental in vitro and in vivo experiments ... -
Novel neonatal simulator provides high-fidelity ventilation training comparable to real-life newborn ventilation
(Journal article; Peer reviewed, 2021)Face mask ventilation of apnoeic neonates is an essential skill. However, many non-paediatric healthcare personnel (HCP) in high-resource childbirth facilities receive little hands-on real-life practice. Simulation training ... -
A novel patient-reported outcome monitoring with clinical feedback system in bariatric surgery care: study protocol, design and plan for evaluation
(Journal article; Peer reviewed, 2020)Background: Consultations before and after bariatric surgery should include structured assessments of patients’ health-related quality of life (HRQOL) and mental health. One way to conduct this assessment is to implement ... -
Novel PCDH10-Wnt-MALAT1 regulatory axis in endometrioid endometrial adenocarcinoma
(Peer reviewed; Journal article, 2019)Key Messages: 1. Protocadherin 10 (PCDH10) is silenced in endometrioid endometrial cancer through promoter hypermethylation. 2. Ectopic expression of PCDH10 inhibits tumour growth and induces cell apoptosis. 3. Transcriptomic ... -
Novel Points of Attack for Targeted Cancer Therapy
(Peer reviewed; Journal article, 2015-01)New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ... -
Novel Points of Attack for Targeted Cancer Therapy
(Peer reviewed; Journal article, 2014-10-30)New molecular insight reveals novel points of attack for targeted cancer therapy. The recent advances in cancer genomics and novel insight into the complex biology of cancer make the promise of personalized, targeted cancer ... -
Novel preoperative biomarkers and evaluation of altered treatment strategies to improve outcome for endometrial cancer patients
(Doctoral thesis, 2021-10-01)Background: Endometrial cancer is the most common gynecological cancer among women in countries with a high developmental index, and the incidence is expected to rise. Major controversies in the treatment of endometrial ... -
A Novel Prophylaxis Strategy Using Liposomal Vaccine Adjuvant CAF09b Protects against Influenza Virus Disease
(Journal article; Peer reviewed, 2022-02-06)The SARS-CoV-2 pandemic caused a massive health and societal crisis, although the fast development of effective vaccines reduced some of the impact. To prepare for future respiratory virus pandemics, a pan-viral prophylaxis ... -
Novel RAB27A Variant Associated with Late-Onset Hemophagocytic Lymphohistiocytosis Alters Effector Protein Binding
(Journal article; Peer reviewed, 2022)Autosomal recessive mutations in RAB27A are associated with Griscelli syndrome type 2 (GS2), characterized by hypopigmentation and development of early-onset, potentially fatal hemophagocytic lymphohistiocytosis (HLH). We ... -
Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications: The DOLCE Study From Northern Ukraine
(Journal article; Peer reviewed, 2021)Background: Presently, persons with diabetes are classified as having type 1 (T1D) or type 2 diabetes (T2D) based on clinical diagnosis. However, adult patients exhibit diverse clinical representations and this makes ... -
A novel splice-affecting HNF1A variant with large population impact on diabetes in Greenland
(Journal article; Peer reviewed, 2023)Background: The genetic disease architecture of Inuit includes a large number of common high-impact variants. Identification of such variants contributes to our understanding of the genetic aetiology of diseases and improves ... -
Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain
(Journal article; Peer reviewed, 2022)Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target ... -
Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children
(Peer reviewed; Journal article, 2017-07-19)Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to the development of non-sputum diagnostic tools. We ... -
A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway
(Peer reviewed; Journal article, 2013-01-22)Background: Nested PCR is a commonly used technique in diagnosis of malaria owing to its high sensitivity and specificity. However, it is time-consuming, open to considerable risk of contamination and has low cost-efficiency. ... -
A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway
(Peer reviewed; Journal article, 2013-01-22)Background: Nested PCR is a commonly used technique in diagnosis of malaria owing to its high sensitivity and specificity. However, it is time-consuming, open to considerable risk of contamination and has low cost-efficiency. ... -
“Now that you are circumcised, you cannot have first sex with your wife”: post circumcision sexual behaviours and beliefs among men in Wakiso district, Uganda
(Peer reviewed; Journal article, 2017)Introduction: Safe male circumcision is an important biomedical intervention in the comprehensive HIV prevention programmes implemented in 14 sub-Saharan African countries with high HIV prevalence. To sustain its partial ... -
NPM1-Mutated Patient-Derived AML Cells Are More Vulnerable to Rac1 Inhibition
(Journal article; Peer reviewed, 2022)The prognosis of acute myeloid leukemia (AML) is poor, especially for the elderly population. Targeted therapy with small molecules may be a potential strategy to overcome chemoresistance and improve survival in AML. We ... -
NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson’s disease
(Journal article; Peer reviewed, 2023)Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains ... -
NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients
(Peer reviewed; Journal article, 2018-10-16)Background: The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent state ... -
NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study
(Journal article; Peer reviewed, 2021-09-07)Objective: Whether use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of incident Parkinson’s disease (PD) remains unresolved. Here, we employed the Norwegian Prescription Database to examine whether NSAID ...