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Novel RAB27A Variant Associated with Late-Onset Hemophagocytic Lymphohistiocytosis Alters Effector Protein Binding
(Journal article; Peer reviewed, 2022)Autosomal recessive mutations in RAB27A are associated with Griscelli syndrome type 2 (GS2), characterized by hypopigmentation and development of early-onset, potentially fatal hemophagocytic lymphohistiocytosis (HLH). We ... -
Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications: The DOLCE Study From Northern Ukraine
(Journal article; Peer reviewed, 2021)Background: Presently, persons with diabetes are classified as having type 1 (T1D) or type 2 diabetes (T2D) based on clinical diagnosis. However, adult patients exhibit diverse clinical representations and this makes ... -
A novel splice-affecting HNF1A variant with large population impact on diabetes in Greenland
(Journal article; Peer reviewed, 2023)Background: The genetic disease architecture of Inuit includes a large number of common high-impact variants. Identification of such variants contributes to our understanding of the genetic aetiology of diseases and improves ... -
Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain
(Journal article; Peer reviewed, 2022)Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target ... -
Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children
(Peer reviewed; Journal article, 2017-07-19)Pediatric tuberculosis (TB) is challenging to diagnose, confirmed by growth of Mycobacterium tuberculosis at best in 40% of cases. The WHO has assigned high priority to the development of non-sputum diagnostic tools. We ... -
A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway
(Peer reviewed; Journal article, 2013-01-22)Background: Nested PCR is a commonly used technique in diagnosis of malaria owing to its high sensitivity and specificity. However, it is time-consuming, open to considerable risk of contamination and has low cost-efficiency. ... -
A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway
(Peer reviewed; Journal article, 2013-01-22)Background: Nested PCR is a commonly used technique in diagnosis of malaria owing to its high sensitivity and specificity. However, it is time-consuming, open to considerable risk of contamination and has low cost-efficiency. ... -
“Now that you are circumcised, you cannot have first sex with your wife”: post circumcision sexual behaviours and beliefs among men in Wakiso district, Uganda
(Peer reviewed; Journal article, 2017)Introduction: Safe male circumcision is an important biomedical intervention in the comprehensive HIV prevention programmes implemented in 14 sub-Saharan African countries with high HIV prevalence. To sustain its partial ... -
NPM1-Mutated Patient-Derived AML Cells Are More Vulnerable to Rac1 Inhibition
(Journal article; Peer reviewed, 2022)The prognosis of acute myeloid leukemia (AML) is poor, especially for the elderly population. Targeted therapy with small molecules may be a potential strategy to overcome chemoresistance and improve survival in AML. We ... -
NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson’s disease
(Journal article; Peer reviewed, 2023)Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains ... -
NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients
(Peer reviewed; Journal article, 2018-10-16)Background: The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent state ... -
NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study
(Journal article; Peer reviewed, 2021-09-07)Objective: Whether use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of incident Parkinson’s disease (PD) remains unresolved. Here, we employed the Norwegian Prescription Database to examine whether NSAID ... -
Nuclear and Mitochondrial Circulating Cell-Free DNA Is Increased in Patients With Inflammatory Bowel Disease in Clinical Remission
(Journal article; Peer reviewed, 2020)Background: The role of cell-free DNA (cfDNA) in the pathogenesis of inflammatory bowel disease (IBD) has been recently suggested. The aim of this study was to analyze circulating cfDNA and deoxyribonuclease (DNase) activity ... -
Nuclear Receptor Coregulators Role of Protein-Protein Interactions and cAMP/PKA Signaling
(Doctoral thesis, 2007-02-02) -
Nuclear Receptor Genes - Regulation and Evolution
(Doctoral thesis, 2016-02-26)Nuclear receptors are transcription factors that typically bind ligands in order to regulate the expression level of their target genes. Members of this family work with their co-regulators and repressors to maintain a ... -
Nucleated red blood cells explain most of the association between DNA methylation and gestational age
(Journal article; Peer reviewed, 2023)Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS of ... -
Number of children: pre- and post-pregnancy lipids, effect of pregnancy outcome and modification by perinatal loss
(Doctoral thesis, 2020-01-07)Background: Cardiovascular disease (CVD) is an important public health problem and remains the number one cause of death in women. Substantial increase in CVD mortality has been found in women with only one child, and lipid ... -
The Nurse Role in the Management of ADHD in Children and Adolescent: A Literature Review
(Journal article; Peer reviewed, 2022)Objective: To review literature regarding existing and recommended roles for nurses in the management of children with ADHD. Methods: MEDLINE and CINAHL were searched from 2010 to the end of 2019 with the following ... -
Nurse-led consultations reinforced with eHealth technology: a qualitative study of the experiences of patients with gynecological cancer
(Journal article; Peer reviewed, 2022-11-25)Background: During the last decade, the health care profession has moved toward personalized care and has focused on the diversity of survivorship needs after initial cancer treatment. Health care providers encourage ... -
Nurse-patient interaction and self-transcendence: assets for a meaningful life in nursing home residents?
(Journal article; Peer reviewed, 2020)Background Due to the shift to an older population worldwide and an increased need for 24-h care, finding new and alternative approaches to increase wellbeing among nursing home (NH) residents is highly warranted. To guide ...