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    • Crystal and solution structure of NDRG1, a membranebinding protein linked to myelination and tumour suppression 

      Mustonen, Venla; Muruganandam, Gopinath; Loris, Remy; Kursula, Petri; Ruskamo, Salla (Journal article; Peer reviewed, 2021)
      N-myc downstream-regulated gene 1 (NDRG1) is a tumour suppressor involved in vesicular trafficking and stress response. NDRG1 participates in peripheral nerve myelination, and mutations in the NDRG1 gene lead to ...

    • Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc 

      Hallin, Erik Ingmar; Markusson, Sigurbjörn; Bottger, Lev; Torda, Andrew E.; Bramham, Clive Raymond Evjen; Kursula, Petri (Journal article; Peer reviewed, 2021)
      Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated protein (Arc). Mammalian Arc forms ...

    • Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics 

      Yadrykhinsky, Vladyslav; Georgiou, Charis; Brenk, Ruth (Journal article; Peer reviewed, 2022)
      Background: FabB (3-oxoacyl-[acyl-carrier-protein] synthase 1) is part of the fatty acid synthesis II pathway found in bacteria and a potential target for antibiotics. The enzyme catalyses the Claisen condensation of ...

    • Crystallographic home-source X-ray data for the atomic-resolution experimental phasing of the Shank3 SH3 domain structure from pseudomerohedrally twinned crystals 

      Ponna, Srinivas Kumar; Myllykoski, Matti; Kursula, Petri (Peer reviewed; Journal article, 2018-10)
      By far most macromolecular crystallographic data collection and experimental phasing is nowadays carried out using synchrotron radiation. Here, we present two crystallographic datasets collected on a home-source X-ray ...

    • CSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosis 

      Bhan, Alok; Jacobsen, Cecilie; Dalen, Ingvild; Bergsland, Niels; Zivadinov, Robert; Alves, Guido Werner; Myhr, Kjell-Morten; Farbu, Elisabeth (Journal article; Peer reviewed, 2021)
      Background Neurofilament light chain (NfL) is an attractive biomarker of disease activity and progression in MS, but there is a lack in long-term prognostic data. Objective To test the long-term clinical and radiological ...

    • CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test 

      Wåtevik, Marie; Frisk, Bente; Real, Francisco Gomez; Hardie, Jon Andrew; Bakke, Per; Eagan, Tomas Mikal Lind; Johannessen, Ane (Journal article; Peer reviewed, 2021)
      Background Emphysema and exercise induced desaturation (EID) are both related to poorer COPD prognosis. More knowledge of associations between emphysema and desaturation is needed for more efficient disease management. ...

    • ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab 

      Forthun, Rakel Brendsdal; Hovland, Randi; Schuster, Cornelia; Puntervoll, Hanne Eknes; Brodal, Hans Petter; Namløs, Heidi Maria; Aasheim, Lars Birger; Meza, Leonardo Zepeda; Gjertsen, Bjørn Tore; Knappskog, Stian; Straume, Oddbjørn (Peer reviewed; Journal article, 2019)
      Bevacizumab is included in an increasing number of clinical trials. To find biomarkers to predict and monitor treatment response, cancer and angiogenesis relevant mutations in tumour and circulating tumour DNA (ctDNA) were ...

    • CTLA-4 as a genetic determinant in autoimmune Addison's disease 

      Wolff, Anette Susanne Bøe; Mitchell, Anna L.; Cordell, Heather J.; Short, Andrea; Skinningsrud, Beate; Ollier, William; Badenhoop, Klaus; Meyer, Gesine; Falorni, Alberto; Kämpe, Olle; Undlien, Dag Erik; Pearce, Simon H.S.; Husebye, Eystein Sverre (Peer reviewed; Journal article, 2015)
      In common with several other autoimmune diseases, autoimmune Addison’s disease (AAD) is thought to be caused by a combination of deleterious susceptibility polymorphisms in several genes, together with undefined environmental ...

    • Cultural beliefs and practices on perinatal death: a qualitative study among the Lango community in Northern Uganda 

      Arach, Anna Agnes Ojok; Nakasujja, Noeline; Rujumba, Joseph; Mukunya, David; Odongkara, Beatrice; Musaba, Milton W.; Napyo, Agnes Kasede; Tumwine, James K; Nankabirwa, Victoria; Ndeezi, Grace; Kiguli, Juliet (Journal article; Peer reviewed, 2023)
      Background Perinatal death has profound psychosocial effects on women and their families. Sociocultural contexts influence the burden, rituals and bereaved’s support. Little is known about cultural beliefs and practices ...

    • The Culture Dish Surface Influences the Phenotype and Cytokine Production of Human Monocyte-Derived Dendritic Cells 

      Sauter, Alexander; Yi, Dag Heiro; Li, Yayan; Roersma, Sabine; Appel, Silke (Peer reviewed; Journal article, 2019-10-02)
      Monocyte-derived dendritic cells (moDC) are an important scientific and clinical source of functional dendritic cells (DC). However, the optimization of the generation process has to date mainly been limited to the variation ...

    • Cumulative incidence of sickness absence and disease burden among the newly sick-listed, a cross-sectional population-based study 

      Ármannsdóttir, Brynja; Mårdby, Ann-Charlotte; Haukenes, Inger; Hensing, Gunnel (Peer reviewed; Journal article, 2013-04-10)
      Background: Sickness absence is a public health problem with economic consequences for individuals and society. Although sickness absence and chronic diseases are correlated, few studies exist concerning the role of chronic ...

    • Cumulative prognostic score predicting mortality in patients older than 80 years admitted to the ICU 

      de Lange, Dylan W.; Brinkman, Sylvia; Flaatten, Hans; Boumendil, Ariane; Morandi, Alessandro; Andersen, Finn Husøy; Artigas, Antonio; Bertolini, Guido; Cecconi, Maurizio; Christensen, Steffen; Faraldi, Loredana; Fjølner, Jesper; Jung, Christian; Marsh, Brian; Moreno, Rui; Oeyen, Sandra; Öhman, Christina Agwald; Bollen Pinto, Bernardo; de Smet, Anne Marie G.A.; Soliman, Ivo W.; Szczeklik, Wojciech; Valentin, Andreas; Watson, Ximena; Zafeiridis, Tilemachos; Guidet, Bertrand (Peer reviewed; Journal article, 2019-06)
      OBJECTIVES To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN Prospective cohort study. SETTING A total of ...

    • Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis 

      Oveland, Eystein; Ahmad, Intakhar; Lereim, Ragnhild Reehorst; Kroksveen, Ann Cathrine; Barsnes, Harald; Guldbrandsen, Astrid; Myhr, Kjell-Morten; Bø, Lars; Berven, Frode Steingrimsen; Wergeland, Stig (Journal article; Peer reviewed, 2021)
      Two pathophysiological different experimental models for multiple sclerosis were analyzed in parallel using quantitative proteomics in attempts to discover protein alterations applicable as diagnostic-, prognostic-, or ...

    • Current clinical criteria for Lynch syndrome are not sensitive enough to identify MSH6 mutation carriers 

      Sjursen, Wenche; Haukanes, Bjørn Ivar; Grindedal, Eli Marie; Aarset, Harald; Stormorken, Astrid Tenden; Engebretsen, Lars Fredrik; Jonsrud, Christoffer; Bjørnevoll, Inga; Andresen, Per Arne; Ariansen, Sarah; Lavik, Liss Anne S.; Gilde, Bodil; Bowitz-Lothe, Inger Marie; Mæhle, Lovise; Møller, Pål (Peer reviewed; Journal article, 2010-09)
      Background: Reported prevalence, penetrance and expression of deleterious mutations in the mismatch repair (MMR) genes, MLH1, MSH2, MSH6 and PMS2, may reflect differences in the clinical criteria used to select families ...

    • Current evidence on basic emergency obstetric and newborn care services in Addis Ababa, Ethiopia; a cross sectional study 

      Mirkuzie, Alemnesh Hailemariam; Sisay, Mitike Molla; Reta, Alemnesh Tekelebirhan; Bedane, Mulu Muleta (Peer reviewed; Journal article, 2014-10-10)
      Background: Emergency obstetric and neonatal care (EmONC) is a high impact priority intervention highly recommended for improving maternal and neonatal health outcomes. In 2008, Ethiopia conducted a national EmONC survey ...

    • Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials 

      Pazan, Farhad; Petrovic, Mirko; Cherubini, Antonio; Onder, Graziano; Cruz-Jentoft, Alfonso J.; Denkinger, Michael D.; van der Cammen, Tischa J. M.; Stevenson, Jennifer M.; Ibrahim, Kinda; Rajkumar, Chakravarthi; Bakken, Marit Stordal; Baeyens, Jean-Pierre; Crome, Peter; Frühwald, Thomas; Gallaghar, Paul; Guðmundsson, Adalsteinn; Knol, Wilma; O’Mahony, Denis; Pilotto, Alberto; Rönnemaa, Elina; Serra-Rexach, José Antonio; Soulis, George; van Marum, Rob J.; Ziere, Gijsbertus; Mair, Alpana; Burkhardt, Heinrich; Neumann-Podczaska, Agnieszka; Wieczorowska-Tobis, Katarzyna; Fernandes, Marilia Andreia; Gruner, Heidi; Dallmeier, Dhayana; Beuscart, Jean-Baptiste; Van Der Velde, Nathalie; Wehling, Martin (Journal article; Peer reviewed, 2021)
      Background Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest ...

    • Current landscape and future perspectives in preclinical MR and PET imaging of brain metastasis 

      Aasen, Synnøve Nymark; Espedal, Heidi; Keunen, Olivier; Adamsen, Tom Christian Holm; Bjerkvig, Rolf; Thorsen, Frits (Journal article; Peer reviewed, 2021)
      Brain metastasis (BM) is a major cause of cancer patient morbidity. Clinical magnetic resonance imaging (MRI) and positron emission tomography (PET) represent important resources to assess tumor progression and treatment ...

    • Current role of endoscopic combined intrarenal surgery in the management of renal stones: A scoping review 

      Nedbal, Carlotta; Jahrreiss, Victoria; Cerrato, Clara; Castellani, Daniele; Kamal, Wissam Khalid; Hameed, Zeeshan; Gauhar, Vineet; Juliebø-Jones, Patrick; Tzelves, Lazaros; Kallidonis, Panagiotis; Tokas, Theodoros; Somani, Bhaskar K. (Journal article; Peer reviewed, 2023)
      Introduction: This study aims to review the current role of endoscopic combined intrarenal surgery (ECIRS) in the management of renal stones, with a focus on its efficacy and safety. The secondary outcome was to highlight ...

    • Current status of fecal microbiota transplantation for irritable bowel syndrome 

      El-Salhy, Magdy; Hausken, Trygve; Hatlebakk, Jan Gunnar (Journal article; Peer reviewed, 2021)
      Background Irritable bowel syndrome (IBS) is a common gastrointestinal functional disorder. Although IBS is a benign condition, it reduces the quality of life considerably. While there is currently no effective treatment ...

    • Current Status of Intravesical Therapies for Bladder Pain Syndrome (BPS): A Narrative Review of Emerging Evidence 

      Jones, Patrick; Hjelle, Karin Margrethe; Mohn, Jannike; Gudbrandsdottir, Gigja; Roth, I; Chaudhry, Adeel Asghar; Bergesen, Anne Kvåle; Beisland, Christian (Journal article; Peer reviewed, 2021)
      Bladder pain syndrome (BPS) is a complex condition, which can have debilitating sequelae for patients. Many elements of BPS remain poorly understood including pathophysiology, diagnosis and treatment. Navigating patient ...