Blar i Faculty of Medicine på tittel

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    • Fucosylated AGP glycopeptides as biomarkers of HNF1A-Maturity onset diabetes of the young 

      Tijardović, Marko; Štambuk, Tamara; Juszczak, Agata; Keser, Toma; Gasperikova, Daniela; Novokmet, Mislav; Tjora, Erling; Pape Medvidović, Edita; Stanik, Juraj; Njølstad, Pål Rasmus; Lauc, Gordan; Owen, Katharine R.; Gornik, Olga (Journal article; Peer reviewed, 2022)
      Aims: We previously demonstrated that antennary fucosylated N-glycans on plasma proteins are regulated by HNF1A and can identify cases of Maturity-Onset Diabetes of the Young caused by HNF1A variants (HNF1A-MODY). Based ...

    • FuelBox Sunn Idrett- prosessevaluering av et dialogverktøy for ungdom om mat, kropp og trening 

      Rogstad, Mia Mårteig (Master thesis, 2022-05-13)
      Bakgrunn: Dialogverktøyet FuelBox Sunn Idrett er et potensielt tiltak for idrettsungdom for å igangsette samtaler og fremme refleksjon rundt vanskelige temaer som mat, kropp og trening. Spiseforstyrrelser er et alvorlig ...

    • Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role? 

      Køstner, Anne Helene; Fuglestad, Anniken Jørlo; Georgsen, Jeanette Baehr; Nielsen, Patricia Switten; Christensen, Kristina Bang; Zibrandtsen, Helle; Parner, Erik Thorlund; Rajab, Ibraheem M.; Potempa, Lawrence A.; Steiniche, Torben; Kersten, Christian (Journal article; Peer reviewed, 2023-03-17)
      Background: Systemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types. CRP exists ...

    • Full breastfeeding protection against common enteric bacteria and viruses: Results from the MAL-ED cohort study 

      Mccormick, Benjamin J. J; Richard, Stephanie A; Murray-Kolb, Laura E; Kang, Gagandeep; Lima, Aldo A. M; Mduma, Estomih; Kosek, Margaret N; Rogawski Mcquade, Elizabeth T; Houpt, Eric R; Bessong, Pascal; Shrestha, Sanjaya; Bhutta, Zulfiqar; Ahmed, Tahmeed; Caulfield, Laura E; Acosta, Angel Mendez; De Burga, Rosa Rios; Chavez, Cesar Banda; Flores, Julian Torres; Olotegui, Maribel Paredes; Pinedo, Silvia Rengifo; Salas, Mery Siguas; Trigoso, Dixner Rengifo; Vasquez, Angel Orbe; Ahmed, Imran; Alam, Didar; Ali, Asad; Bhutta, Zulfiqar A.; Qureshi, Shahida; Rasheed, Muneera Abdul; Soofi, Sajid; Turab, Ali; Yousafzai, Aisha; Zaidi, Anita K. M.; Bodhidatta, Ladaporn; Ammu, Geetha; Babji, Sudhir; Bose, Anuradha; George, Ajila T.; Hariraju, Dinesh; Jennifer, M Steffi; John, Sushil; Kaki, Shiny; Karunakaran, Priyadarshani; Koshy, Beena; Lazarus, Robin P.; Muliyil, Jayaprakash; Ragasudha, Preethi; Raghava, Mohan Venkata; Raju, Sophy; Ramachandran, Anup; Ramadas, Rakhi; Ramanujam, Karthikeyan; Rose, Anuradha; Roshan, Reeba; Sharma, Srujan L.; Shanmuga Sundaram, Sundaram; Thomas, Rahul J.; Pan, William K.; Ambikapathi, Ramya; Carreon, J. Daniel; Doan, Viyada; Hoest, Christel; Knobler, Stacey; McCormick, Benjamin J. J.; McGrath, Monica; Miller, Mark A.; Psaki, Stephanie; Rasmussen, Zeba; Seidman, Jessica C.; Gottlieb, Michael; Lang, Dennis R.; Tountas, Karen H.; Svensen, Erling; Amour, Caroline; Bayyo, Eliwaza; Mduma, Estomih R.; Mvungi, Regisiana; Nshama, Rosemary; Pascal, John; Swema, Buliga Mujaga; Yarrot, Ladislaus; Mason, Carl J.; Shamsir Ahmed, Ahmed; Alam, Md Ashraful; Haque, Rashidul; Haque, Umma; Hossain, Md Iqbal; Islam, Munirul; Mahfuz, Mustafa; Mondal, Dinesh; Nahar, Baitun; Tofail, Fahmida; Chandyo, Ram Krishna; Shrestha, Prakash Sunder; Shrestha, Rita; Chandyo, Manjeswori Ulak; Bauck, Aubrey; Black, Robert E.; Checkley, William; Lee, Gwenyth O.; Schulze, Kerry; Yori, Pablo Peñataro; Ross, A. Catharine; Schaefer, Barbara; Simons, Suzanne; Pendergast, Laura; Abreu, Cláudia B.; Costa, Hilda; Di Moura, Alessandra; Filho, José Quirino; Havt, Alexandre; Leite, Álvaro M.; Lima, Noélia L.; Lima, Ila F.; Maciel, Bruna L. L.; Medeiros, Pedro H. Q. S.; Moraes, Milena; Mota, Francisco S.; Oriá, Reinaldo B.; Quetz, Josiane; Soares, Alberto M.; Mota, Rosa M. S.; Patil, Crystal L.; Mahopo, Cloupas; Maphula, Angelina; Nyathi, Emanuel; Samie, Amidou; Barrett, Leah; Dillingham, Rebecca; Gratz, Jean; Guerrant, Richard L.; Houpt, Eric; Petri, William A.; Platts-Mills, James; Rogawski, Elizabeth; Scharf, Rebecca; Rogawski, Elizabeth T.; Shrestha, Binob; Rayamajhi, Bishnu Bahadur; Strand, Tor Arne (Journal article; Peer reviewed, 2022)
      Background Breastfeeding is known to reduce the risk of enteropathogen infections, but protection from specific enteropathogens is not well characterized. Objective The aim was to estimate the association between full ...

    • Fun, influence and competence-a mixed methods study of prerequisites for high school students' participation in physical education 

      Abildsnes, Eirik; Rohde, Gudrun E.; Berntsen, Sveinung; Stea, Tonje Holte (Peer reviewed; Journal article, 2017-03-10)
      Background: Many adolescents do not reach the recommended levels of physical activity (PA), and students attending vocational studies are less committed to take part in physical education (PE) than other students. The ...

    • Function and regulation of phenylalanine and tyrosine hydroxylases from human and Caenorhabditis elegans. With focus in evolutionary aspects and development of new therapies 

      Calvo, Ana C. (Doctoral thesis, 2010-06-11)
      The family of the aromatic amino acid hydroxylases (AAAH) is well studied in mammals. It includes four members, i.e. phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and the tryptophan hydroxylases (TPH1 and 2). ...

    • Function and regulation of Steroid Receptor Coactivator 2. Transcriptional regulation of cellular metabolism 

      Madsen, Andre (Doctoral thesis, 2015-12-18)
      Nuclear hormone receptors (NRs) associate with coregulators to enable complex programs of gene expression. The p160 steroid receptor coactivator 2 (SRC- 2/GRIP1) regulates metabolism and cellular processes in a tissue-specific ...

    • A function of profilin in force generation during malaria parasite motility that is independent of actin binding 

      Moreau, Catherine A.; Quadt, Katharina A.; Piirainen, Henni; Kumar, Hirdesh; Bhargav, Saligram P.; Strauss, Léanne; Tolia, Niraj H; Wade, Rebecca C.; Spatz, Joachim P; Kursula, Inari; Frischknecht, Friedrich (Journal article; Peer reviewed, 2020)
      During transmission of malaria-causing parasites from mosquito to mammal, Plasmodium sporozoites migrate at high speed within the skin to access the bloodstream and infect the liver. This unusual gliding motility is based ...

    • Functional analyses of BRCA1 variants of unknown significance found in hereditary breast or ovarian cancer families in Norway: A tool for improved diagnosis 

      Hovland, Henrikke Nilsen (Doctoral thesis, 2023-03-21)
      Tumorsuppressorgenet BRCA1 speler mange viktige roller for å hindre tumorutvikling, og endringar i BRCA1-genet er ei av hovudårsakene til arveleg bryst- og eggstokk-kreft (HBOC). I artikkel I vart det laga ei oversikt over ...

    • Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions 

      Hovland, Henrikke Nilsen; Mchaina, Eunice Kabanyana; Vetti, Hildegunn Høberg; Ariansen, Sarah Louise; Sjursen, Wenche; Van Ghelue, Marijke; Haukanes, Bjørn Ivar; Knappskog, Per Morten; Aukrust, Ingvild; Berge, Elisabet Ognedal (Journal article; Peer reviewed, 2023-01-19)
      The BRCA1 protein is implicated in numerous important cellular processes to prevent genomic instability and tumorigenesis, and pathogenic germline variants predispose carriers to hereditary breast and ovarian cancer (HBOC). ...

    • Functional analysis of tilS homologues in Bacteria and Archaea 

      Stavrum, Ruth (Master thesis, 2005-09-09)
      Out of all of the microorganisms sequenced so far about one third of the genes have unknown function. Several studies have shown that information on evolutionary relationships between unknown genes can aid in the prediction ...

    • Functional and animal studies of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), a fatty acid beta-oxidation enzyme involved in congenital hyperinsulinism of infancy 

      St-Louis, Johanna (Doctoral thesis, 2021-02-16)
      Short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) is a mitochondrial enzyme involved in fatty acid β-oxidation and the regulation of β-cell insulin secretion. Its role in insulin secretion became apparent in 2001 when ...

    • Functional and Binding H1N1pdm09-Specific Antibody Responses in Occasionally and Repeatedly Vaccinated Healthcare Workers: A Five-Year Study (2009-2014) 

      Amdam, Håkon; Madsen, Anders; Zhou, Fan; Bansal, Amit; Trieu, Mai Chi; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      Background: In 2009, a novel influenza A/H1N1pdm09 emerged and caused a pandemic. This strain continued to circulate and was therefore included in the seasonal vaccines up to the 2016/2017-season. This provided a unique ...

    • Functional and Prognostic Role of MicroRNAs in Cancer Associated Fibroblasts and Stroma in Oral Squamous Cell Carcinoma 

      Rajthala, Saroj (Doctoral thesis, 2023-11-23)
      Nyere studier har vist at forandringer i bindevevscellene som omgir kreftsvulsten er viktige for utviklingen av munnhulekreft. Kreft stroma kan regulere fenotypen av kreftcellene, og på den måten kan påvirke klinisk forløpet ...

    • Functional characterization of all-trans retinoic acid-induced differentiation factor (ATRAID) 

      Mehrasa, Roya; Cristea, Ileana; Bredrup, Cecilie; Rødahl, Eyvind; Bruland, Ove (Journal article; Peer reviewed, 2023)
      All-trans retinoic acid-induced differentiation (ATRAID) factor was first identified in HL60 cells. Several mRNA isoforms exist, but the respective proteins have not been fully characterized. In transfected cells expressing ...

    • Functional characterization of genetic risk factors in autoimmune Addison’s disease 

      Aslaksen, Sigrid (Doctoral thesis, 2020-10-23)
      Autoimmune diseases occur when the immune system attacks and damages the body’s own tissue. Why people develop these diseases, and how the autoimmune reaction develops are unanswered questions. Autoimmune Addison's disease ...

    • Functional evaluation and work participation in health care workers with musculoskeletal disorders 

      Ask, Tove (Doctoral thesis, 2016-06-22)
      Background: In Norway and other western countries, musculoskeletal disorders (MSDs) are the most frequent reasons for sick leave and disability pensions, and particularly employees in the health and social sector have a ...

    • Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro 

      Velasco Pinto, Kelly; St-Louis, Johanna; Hovland, Henrikke N.; Thompson, Nels; Ottesen, Åsta; Choi, Man Hung; Pedersen, Line; Njølstad, Pål Rasmus; Arnesen, Thomas; Fjeld, Karianne; Aukrust, Ingvild; Myklebust, Line Merethe; Molven, Anders (Journal article; Peer reviewed, 2021)
      Short‐chain 3‐hydroxyacyl‐CoA dehydrogenase (SCHAD), encoded by the HADH gene, is a ubiquitously expressed mitochondrial enzyme involved in fatty acid oxidation. This protein also plays a role in insulin secretion as ...

    • Functional Gastrointestinal Disorders following Giardia infection : Visceral hypersensitivity and low-grade inflammation 

      Dizdar, Vernesa (Doctoral thesis, 2020-10-20)
      Background: Giardia lamblia is a non-invasive protozoan parasite, infecting mainly the upper small intestine. It is the most common cause of waterborne outbreaks of diarrhea in an endemic country. The first registered ...

    • Functional imaging to promote individualized and targeted therapy in endometrial cancer 

      Husby, Jenny Hild Aase (Doctoral thesis, 2016-02-05)
      Background: Endometrial carcinoma is the most common pelvic malignancy in the Western world and the incidence is increasing. Endometrial carcinomas are surgically staged according to FIGO 2009 criteria, and the lack of ...