Browsing Faculty of Medicine by Title
Now showing items 6014-6033 of 8753
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p53 protein biosignatures in acute myeloid leukemia
(Doctoral thesis, 2006-03-10)p53 is a tumor suppressor protein often regarded as the guardian of the genome. It is a highly connected protein involved in many signaling processes in the cell. The inactivation of p53 through genetic mutations in TP53 ... -
p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy
(Journal article; Peer reviewed, 2021)p53 protein isoform expression has been found to correlate with prognosis and chemotherapy response in acute myeloid leukemia (AML). We aimed to investigate how p53 protein isoforms are modulated during epigenetic ... -
Paediatric Contacts of Adult COVID-19 Patients: Clinical Parameters, Risk Factors, and Outcome
(Journal article; Peer reviewed, 2021)Background. There is insufficient data in Pakistan and in South Asia regarding paediatric COVID-19 demographics and related parameters. The main aim of this study was to assess the paediatric population exposed to SARS-CoV-2 ... -
Paediatric HIV-1 infection in Uganda. Natural history and early antiretroviral treatment response
(Doctoral thesis, 2011-10-07)Paediatric HIV-1 infection remains a major problem for sub-Saharan Africa with over 1300 new infections daily. Infected children have a high mortality with 50% dying by 2 years of age. Access to antiretroviral therapy (ART) ... -
Paediatric kidney stone surgery: state-of-the-art review
(Journal article; Peer reviewed, 2023)While urolithiasis in children is rare, the global incidence is rising, and the volume of minimally invasive surgeries being performed reflects this. There have been many developments in the technology, which have supported ... -
Paediatric surgical conditions in malawi-a cross-sectional nationwide household survey
(Journal article; Peer reviewed, 2021)Background Untreated surgical conditions may lead to lifelong disability in children. Treating children with surgical conditions may reduce long-term effects of morbidity and disability. Unfortunately, low- and middle-income ... -
Paediatric Ureteroscopy (P-URS) reporting checklist: a new tool to aid studies report the essential items on paediatric ureteroscopy for stone disease
(Journal article, 2023)The burden of urolithiasis in children is increasing and this is mirrored by the number of surgical interventions in the form of ureteroscopy (URS). There exist many challenges in performing this surgery for this special ... -
The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase
(Journal article; Peer reviewed, 2021)Phenylketonuria (PKU) is caused by autosomal recessive variants in phenylalanine hydroxylase (PAH), leading to systemic accumulation of L-phenylalanine (L-Phe) that may reach neurotoxic levels. A homozygous Pah-R261Q mouse, ... -
Pain and pain tolerance in whiplash-associated disorders:A population-based study
(Peer reviewed; Journal article, 2015)Background: Pain is a cardinal symptom in individuals with whiplash-associated disorders (WAD). We aimed to compare pain characteristics between individuals with WAD and individuals reporting chronic pain from other causes, ... -
Pain and physical function among nursing home patients and people with dementia. Cross-sectional analyses from the COSMOS-trial
(Master thesis, 2018-08-24)Background: Previous studies have shown how nursing home patients have poor physical functioning and are largely care dependent in activities of daily life. These patients have a high prevalence of pain and are mainly ... -
Pain and quality of life in nursing home residents with dementia after admission – a longitudinal study
(Journal article; Peer reviewed, 2023-09-27)Background: Pain in nursing home (NH) residents with dementia is commonly reported and may affect Quality of Life (QoL) negatively. Few longitudinal studies have explored how pain and QoL develop in NH residents with ... -
The Pain Assessment in Impaired Cognition scale (PAIC15): A multidisciplinary and international approach to develop and test a meta-tool for pain assessment in impaired cognition, especially dementia
(Journal article; Peer reviewed, 2020)Background: Over the last decades, a considerable number of observational scales have been developed to assess pain in persons with dementia. The time seems ripe now to build on the knowledge and expertize implemented in ... -
Pain complaints after consecutive nights and quick returns in Norwegian nurses working three-shift rotation: an observational study
(Journal article; Peer reviewed, 2020)Objectives To determine whether nurses working consecutive night shifts, or short transitions between shifts (quick returns (QRs)), yielded higher risk for pain complaints when compared with regular morning shifts. Sleep ... -
Pain in dementia
(Journal article; Peer reviewed, 2020)The ageing revolution is changing the composition of our society with more people becoming very old with higher risks for developing both pain and dementia. Pain is normally signaled by verbal communication, which becomes ... -
Pain management in patients with dementia
(Peer reviewed; Journal article, 2013-10-31)There are an estimated 35 million people with dementia across the world, of whom 50% experience regular pain. Despite this, current assessment and treatment of pain in this patient group are inadequate. In addition to the ... -
Pain pressure threshold algometry in knee osteoarthritis: intra- and inter-rater reliability
(Journal article; Peer reviewed, 2023)Introduction: Synovitis and effusion can cause pain sensitization in persons with knee osteoarthritis (KOA). Pain Pressure Threshold (PPT) algometry is a means to quantify somatosensory abnormalities, including ... -
Pain relief from nonpharmacological interventions in the intensive care unit: A scoping review
(Journal article; Peer reviewed, 2020)Aims and Objectives: To describe what is known from the existing literature on nonpharmacological interventions targeting pain in patients admitted to the ICU. Background: Patients receiving intensive care nursing are ... -
Pain, Complex Chronic Conditions and Potential Inappropriate Medication in People with Dementia. Lessons Learnt for Pain Treatment Plans Utilizing Data from the Veteran Health Administration
(Journal article; Peer reviewed, 2021)Alzheimer’s disease and related dementias (ADRD), pain and chronic complex conditions (CCC) often co-occur leading to polypharmacy and with potential inappropriate medications (PIMs) use, are important risk factors for ... -
Pain, coping, and barriers to pain management in outpatients with cancer
(Doctoral thesis, 2009-01-20) -
A painful experience of limited understanding: healthcare professionals’ experiences with palliative care of people with severe dementia in Norwegian nursing homes
(Peer reviewed; Journal article, 2018-02-13)Background: People dying with dementia have significant healthcare needs, and palliative care, with its focus on comfort and quality of life, should be made available to these patients. The aim of this study was to explore ...