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Characterization of immune cell infiltrate in tumor stroma and epithelial compartments in oral squamous cell carcinomas of Sudanese patients
(Journal article; Peer reviewed, 2021)Background Tumor immune infiltrate has been explored in oral squamous cell carcinoma (OSCC), but studies on simultaneous characterization of multiple immune cell subtypes separately in stromal and intraepithelial tumor ... -
CHARACTERIZATION OF IMMUNE CELL SUBSETS IN A MODEL DISEASE FOR ENDOCRINE AUTOIMMUNITY BY MASS AND FLOW CYTOMETRY
(Master thesis, 2022-06-01)The autoimmune polyendocrine syndrome type 1 (APS1) is a complex and rare monogenic form of autoimmunity caused by pathogenic variants of the autoimmune regulator (AIRE) gene; a transcription factor primarily expressed in ... -
Characterization of Melanoma Brain Metastasis Cell Lines
(Master thesis, 2019-06-03)Brain metastasis is a major public health problem. Metastatic brain tumors are ten times more common than that of all other primary brain tumors combined. The estimated annual incidence in Europe is around 1.5 million cases ... -
Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy
(Journal article; Peer reviewed, 2022)Background: Many severe asthma patients with high oral corticosteroid exposure (HOCS) often do not initiate biologics despite being eligible. This study aimed to compare the characteristics of severe asthma patients with ... -
Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism
(Journal article; Peer reviewed, 2021)Porphobilinogen deaminase (PBGD), the third enzyme in the heme biosynthesis, catalyzes the sequential coupling of four porphobilinogen (PBG) molecules into a heme precursor. Mutations in PBGD are associated with acute ... -
Characterization of the genetic architecture of infant and early childhood body mass index
(Journal article; Peer reviewed, 2022)Early childhood obesity is a growing global concern; however, the role of common genetic variation on infant and child weight development is unclear. Here, we identify 46 loci associated with early childhood body mass index ... -
Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes
(Peer reviewed; Journal article, 2019-08-01)Hassallidins are cyclic glycolipopeptides produced by cyanobacteria and other prokaryotes. The hassallidin structure consists of a peptide ring of eight amino acids where a fatty acid chain, additional amino acids, and ... -
Characterization of the PLP-dependent decarboxylases GADL1 and CSAD
(Doctoral thesis, 2022-03-31)Pyridoxal 5’-phosphate (PLP) -dependent enzymes constitute an essential superfamily of enzymes for all living organisms. Due to the chemistry of their cofactor, PLP, these enzymes catalyze a wide variety of reactions. ... -
Characterization of the renal function in Epac1 (RapGef3) knockout mice
(Master thesis, 2014-06-03)The discovery of the exchange proteins directly activated by cAMP (Epac) has renewed our knowledge of intracellular cAMP signaling. The Epac1 isoform (RapGef3) shows high expression level in the kidney. In vitro studies ... -
Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes
(Journal article; Peer reviewed, 2021)Background: A range of sleep disturbances are commonly experienced by patients with psychiatric disorders, and genome-wide genetic analyses have shown some significant genetic correlations between these traits. Here, we ... -
Characterizing the heterogeneous course of inattention and hyperactivity‑impulsivity from childhood to young adulthood
(Journal article; Peer reviewed, 2021)To advance understanding of the heterogeneity in the course of ADHD, joint symptom trajectories of inattention and hyperactivity-impulsivity from childhood to young adulthood were modelled and associated with genetic, ... -
A checklist for identifying determinants of practice: A systematic review and synthesis of frameworks and taxonomies of factors that prevent or enable improvements in healthcare professional practice
(Peer reviewed; Journal article, 2013-03-23)Background: Determinants of practice are factors that might prevent or enable improvements. Several checklists, frameworks, taxonomies, and classifications of determinants of healthcare professional practice have been ... -
Checklists in the operating room: Help or hurdle? A qualitative study on health workers' experiences
(Peer reviewed; Journal article, 2010-12-20)Background: Checklists have been used extensively as a cognitive aid in aviation; now, they are being introduced in many areas of medicine. Although few would dispute the positive effects of checklists, little is known ... -
CHEK2 Mutations Affecting Kinase Activity Together With Mutations in TP53 Indicate a Functional Pathway Associated with Resistance to Epirubicin in Primary Breast Cancer
(Peer reviewed; Journal article, 2008-08-26)Background: Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis ... -
Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria
(Journal article; Peer reviewed, 2021)Cyanobacteria produce a variety of chemically diverse cyclic lipopeptides with potent antifungal activities. These cyclic lipopeptides have an amphipathic structure comprised of a polar peptide cycle and hydrophobic fatty ... -
Chemokines are secreted by monocytes following OK-432 (lyophilized Streptococcus pyogenes) stimulation
(Peer reviewed; Journal article, 2009-01-28)Background: OK-432, penicillin-killed Streptococcus pyogenes, is used in treating lymphangiomas and carcinomas. We have studied in vitro the role of mononuclear phagocytes (MNPs), including purified monocytes (MOs), in the ... -
Cherenkov luminescence imaging for assessment of radioactive plaque position in brachytherapy of uveal melanoma: An in vivo feasibility study
(Journal article; Peer reviewed, 2020)Purpose: To study the feasibility of using Cherenkov luminescence imaging (CLI) to evaluate and document ruthenium-106 plaque position during brachytherapy of uveal melanoma. Methods: Ruthenium-106 decays by emitting ... -
Chest pain out-of-hours – an interview study of primary care physicians’ diagnostic approach, tolerance of risk and attitudes to hospital admission
(Peer reviewed; Journal article, 2014-12-21)Background: Acute chest pain constitutes a considerable diagnostic challenge outside hospitals. This will often lead to uncertainty in choosing the right management, and the physicians’ approach may be influenced by their ... -
A chicken protein hydrolysate exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in Apoe−/− mice
(Peer reviewed; Journal article, 2019-01-13)Chicken protein hydrolysates (CPHs) generated from rest raw materials through enzymatic hydrolysis using Corolase PP or Alcalase were shown to reduce inflammation and stimulate hepatic mitochondrial fatty acid oxidation ...