Blar i Faculty of Medicine på tittel
Viser treff 3969-3988 av 8821
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Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins
(Journal article; Peer reviewed, 2023)Loss-of-function mutations in hepatocyte nuclear factor 1A (HNF1A) are known to cause rare forms of diabetes and alter hepatic physiology through unclear mechanisms. In the general population, 1:100 individuals carry a ... -
Human gingival epithelial cells stimulate proliferation, migration, and tube formation of lymphatic endothelial cells in vitro
(Journal article; Peer reviewed, 2023)Objective The aim of this study was to investigate the response of gingival epithelial cells to microbial and inflammatory signals. Background The gingival epithelial barrier provides the first line of defense and ... -
A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia
(Journal article; Peer reviewed, 2021)While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent ... -
Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
(Journal article; Peer reviewed, 2020)The etiology and pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are unknown, and autoimmunity is one of many proposed underlying mechanisms. Human Leukocyte Antigen (HLA) associations are ... -
Human mucosal IgA immune responses against enterotoxigenic escherichia coli
(Journal article; Peer reviewed, 2020-08-29)Infection with enterotoxigenic Escherichia coli (ETEC) is a major contributor to diarrheal illness in children in low- and middle-income countries and travelers to these areas. There is an ongoing effort to develop vaccines ... -
Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants
(Journal article; Peer reviewed, 2021)Peripheral myelin protein 2 (P2) is a fatty acid-binding protein expressed in vertebrate peripheral nervous system myelin, as well as in human astrocytes. Suggested functions of P2 include membrane stacking and lipid ... -
Human myelin proteolipid protein structure and lipid bilayer stacking
(Journal article; Peer reviewed, 2022)The myelin sheath is an essential, multilayered membrane structure that insulates axons, enabling the rapid transmission of nerve impulses. The tetraspan myelin proteolipid protein (PLP) is the most abundant protein of ... -
Human NAA30 can rescue yeast mak3∆ mutant growth phenotypes
(Journal article; Peer reviewed, 2021)N-terminal acetylation is an irreversible protein modification that primarily occurs co-translationally, and is catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). The NatC complex (NAA30–NAA35–NAA38) ... -
Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 respiratory virus
(Journal article; Peer reviewed, 2022)The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of unprecedented research efforts to understand the pathogenesis mediated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). ... -
Human pancreatic glucokinase. Structural and physico-chemical studies related to catalytic activation, kinetic cooperativity and GCK-diabetes.
(Doctoral thesis, 2012-10-19)Glucokinase (GK) functions as a glucose sensor in insulin-producing pancreatic-cells and as a regulator of hepatic glycolysis, glycogen synthesis and gluconeogenesis. Its key role in glucose homeostasis is evidenced by ... -
Human resources for emergency obstetric care in northern Tanzania: distribution of quantity or quality?
(Peer reviewed; Journal article, 2005-07-29)Background: Health care agencies report that the major limiting factor for implementing effective health policies and reforms worldwide is a lack of qualified human resources. Although many agencies have adopted policy ... -
Human seroprevalence of antibodies to tick-borne microbes in southern Norway
(Journal article; Peer reviewed, 2020)The tick Ixodes ricinus is widespread along the coastline of southern Norway, but data on human exposure to tick-borne microbes are scarce. We aimed to assess the seroprevalence of IgG antibodies to various tick-borne ... -
Human tyrosine hydroxylase: Oxygen dependence and role in Dopa responsive dystonia
(Doctoral thesis, 2016-10-07)The aromatic amino acid hydroxylases (AAHs); phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), tryptophan hydroxylase 1 and 2 (TPH 1/TPH 2); are structurally and functionally related enzymes. All AAHs require ... -
Human-biting activities of Anopheles species in south-central Ethiopia
(Peer reviewed; Journal article, 2016-09-30)Background: Indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) are the key malaria vector control interventions in Ethiopia. The success of these interventions rely on their efficacy to repel or kill ... -
Humanized Ovarian Cancer Patient-Derived Xenografts for Improved Preclinical Evaluation of Immunotherapies
(Journal article; Peer reviewed, 2022)High-grade serous ovarian cancer (HGSOC) has poor prognosis and new treatment modalities are needed. Immunotherapy, with checkpoint inhibitors, have demonstrated limited impact. To evaluate the suitability for immunotherapeutics, ... -
Humoral and cellular immune responses after pandemic and seasonal influenza vaccination in humans
(Doctoral thesis, 2022-06-22)Vaccination is the most effective prophylaxis against epidemic and pandemic influenza. Annual seasonal influenza vaccination is recommended for high-risk groups such as younger children <5 years old and occupational workers ... -
Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations
(Journal article; Peer reviewed, 2021)Introduction The effect of disease-modifying therapies (DMT) on vaccine responses is largely unknown. Understanding the development of protective immunity is of paramount importance to fight the COVID-19 pandemic. Objective ... -
Humoral response to Epstein-Barr virus in patients with multiple sclerosis treated with B cell depletion therapy
(Journal article; Peer reviewed, 2023)Background B cell depletion therapy is highly effective in relapsing-remitting multiple sclerosis (RRMS). However, the precise underlying mechanisms of action for its biological effects in MS have still not been clarified. ... -
Hva består oksymetriparametrene på blodgassutskriften av?
(Journal article, 2022)