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Increased Expression of Fas Ligand in Human Tuberculosis and Leprosy Lesions: a Potential Novel Mechanism of Immune Evasion in Mycobacterial Infection
(Peer reviewed; Journal article, 2001-12)To study the location and mechanism of apoptosis within the human tuberculosis (TB) and leprosy lesions, parallel sections were analyzed for mycobacterial antigens (M.Ag), Fas ligand (FasL), Fas, CD68 and Mac387 by ... -
Increased fairness in priority setting processes within the health sector: the case of Kapiri-Mposhi District, Zambia
(Peer reviewed; Journal article, 2014-02-18)Background: The challenge of priority setting (PS) in health care within contexts of severe resource limitations has continued to receive attention. Accountability for Reasonableness (AFR) has emerged as a useful framework ... -
Increased Fibrosis and Interstitial Fluid Pressure in Two Different Types of Syngeneic Murine Carcinoma Grown in Integrin β3-Subunit Deficient Mice
(Peer reviewed; Journal article, 2012-03-30)Stroma properties affect carcinoma physiology and direct malignant cell development. Here we present data showing that αVβ3 expressed by stromal cells is involved in the control of interstitial fluid pressure (IFP), ... -
Increased gastric chromogranin A cell density following changes to diets of patients with irritable bowel syndrome
(Peer reviewed; Journal article, 2014-11)The gut endocrine cells control and regulate several functions of the gastrointestinal tract. They have been reported to be abnormal in irritable bowel syndrome (IBS), with alterations occurring in several functions regulated ... -
Increased Health Risk in Subjects with High Self-Reported Seasonality
(Peer reviewed; Journal article, 2010-03-03)Background: Seasonal variations in mood and behaviour, termed seasonality, are commonly reported in the general population. As a part of a large cross-sectional health survey in Hordaland, Norway, we investigated the ... -
Increased incidence of postoperative infections during prophylaxis with cephalothin compared to doxycycline in intestinal surgery
(Peer reviewed; Journal article, 2009-12-07)Background: The antibiotics used for prophylaxis during surgery may influence the rate of surgical site infections. Tetracyclines are attractive having a long half-life and few side effects when used in a single dose ... -
Increased infiltration and tolerised antigen-specific CD8+ TEM cells in tumor but not peripheral blood have no impact on survival of HCMV+ glioblastoma patients
(Peer reviewed; Journal article, 2017)Human cytomegalovirus (HCMV) antigens in glioblastoma (GBM) present opportunities for personalised immunotherapy. However, their presence in GBM tissue is still under debate, and evidence of their impact on functional ... -
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
(Journal article; Peer reviewed, 2020-12)In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and ... -
Increased level of acute phase reactants in patients infected with modern Mycobacterium tuberculosis genotypes in Mwanza, Tanzania
(Peer reviewed; Journal article, 2014-06-05)Background: There is increasing evidence to suggest that different Mycobacterium tuberculosis lineages cause variations in the clinical presentation of tuberculosis (TB). Certain M. tuberculosis genotypes/lineages have ... -
Increased microvascular permeability in mice lacking Epac1 (Rapgef3)
(Peer reviewed; Journal article, 2017-02)Aim: Maintenance of the blood and extracellular volume requires tight control of endothelial macromolecule permeability, which is regulated by cAMP signalling. This study probes the role of the cAMP mediators rap guanine ... -
Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas
(Peer reviewed; Journal article, 2014)Background: We aimed to study the angiogenic profile based on histomorphological markers in endometrial carcinomas in relation to imaging parameters obtained from preoperative dynamic contrast-enhanced magnetic resonance ... -
Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumour model
(Peer reviewed; Journal article, 2009-08)Elevated tumor interstitial fluid pressure (TIFP) is a characteristic of most solid tumors. Clinically, TIFP may hamper the uptake of chemotherapeutic drugs into the tumor tissue reducing their therapeutic efficacy. In ... -
Increased Plasma Levels of Triglyceride-Enriched Lipoproteins Associate with Systemic Inflammation, Lipopolysaccharides, and Gut Dysbiosis in Common Variable Immunodeficiency
(Journal article; Peer reviewed, 2023)Purpose: Triglycerides (TG) and their major transport lipoprotein in the circulation (VLDL) appear to be related to inflammation. Patients with common variable immunodeficiency (CVID) have inflammatory complications ... -
Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms
(Journal article; Peer reviewed, 2020)Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic β cells. Further, patients with T1D have 3–4-fold increased risk of developing micro- and ... -
Increased risk of atrial fibrillation among elderly Norwegian men with a history of long-term endurance sport practice
(Journal article; Peer reviewed, 2014)Atrial fibrillation (AF) is the most common cardiac arrhythmia. The prevalence increases with increasing age. In middle-aged men, endurance sport practice is associated with increased risk of AF but there are few studies ... -
Increased risk of hospitalisation and intensive care admission associated with reported cases of SARS-CoV-2 variants B.1.1.7 and B.1.351 in Norway, December 2020-May 2021
(Journal article; Peer reviewed, 2021)Introduction Since their emergence, SARS-CoV-2 variants of concern (VOC) B.1.1.7 and B.1.351 have spread worldwide. We estimated the risk of hospitalisation and admission to an intensive care unit (ICU) for infections ... -
Increased risk of periodontitis in patients with rheumatoid arthritis: A nationwide register study in Norway
(Journal article; Peer reviewed, 2023)Aim To investigate the risk of periodontitis in rheumatoid arthritis (RA) patients in a nationwide register-based study. Materials and Methods Patients and controls were defined using ICD-10 codes registered in the ... -
Increased risk of peripartum perinatal mortality in unplanned births outside an institution: a retrospective population-based study
(Peer reviewed; Journal article, 2017-08)Background: Births in midwife-led institutions may reduce the frequency of medical interventions and provide cost-effective care, while larger institutions offer medically and technically advanced obstetric care. Unplanned ... -
Increased risk of revision for infection in rheumatoid arthritis patients with total hip replacements. A study of 390,671 primary arthroplasties from the Nordic Arthroplasty Register Association
(Peer reviewed; Journal article, 2015)Background and purpose — Medical treatment of rheumatoid arthritis (RA) has changed dramatically over the last 15 years, including immune modulation. We investigated the risk of revision for infection after primary total ... -
Increased risk of revision of cementless stemmed total hip arthroplasty with metal-on-metal bearingsData from the Nordic Arthroplasty Register Association
(Peer reviewed; Journal article, 2015)Background and purpose — Data from the national joint registries in Australia and England and Wales have revealed inferior medium-term survivorship for metal-on-metal (MoM) total hip arthroplasty (THA) than for ...