Browsing Faculty of Medicine by Title
Now showing items 6888-6907 of 8839
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Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid
(Journal article; Peer reviewed, 2021)All-trans retinoic acid (ATRA) and valproic acid (VP) have been tried in the treatment of non-promyelocytic variants of acute myeloid leukemia (AML). Non-randomized studies suggest that the two drugs can stabilize AML and ... -
The PRoteomics IDEntification (PRIDE) Converter 2 Framework: An Improved Suite of Tools to Facilitate Data Submission to the PRIDE Database and the ProteomeXchange Consortium
(Peer reviewed; Journal article, 2012-12)The original PRIDE Converter tool greatly simplified the process of submitting mass spectrometry (MS)-based proteomics data to the PRIDE database. However, after much user feedback, it was noted that the tool had some ... -
A proteomics sample metadata representation for multiomics integration and big data analysis
(Journal article; Peer reviewed, 2021)The amount of public proteomics data is rapidly increasing but there is no standardized format to describe the sample metadata and their relationship with the dataset files in a way that fully supports their understanding ... -
Proteomics Standards Initiative Extended FASTA Format
(Peer reviewed; Journal article, 2019)Mass-spectrometry-based proteomics enables the high-throughput identification and quantification of proteins, including sequence variants and post-translational modifications (PTMs) in biological samples. However, most ... -
Protocol for a multicentre, parallelgroup, open-label randomised controlled trial comparing ferric carboxymaltose with the standard of care in anaemic Malawian pregnant women: the REVAMP trial
(Journal article; Peer reviewed, 2021)Introduction Anaemia in pregnancy remains a critical global health problem, affecting 46% of pregnant women in Africa and 49% in Asia. Oral iron therapy requires extended adherence to achieve correction of anaemia and ... -
Protocol for data extraction: how realworld data have been used in the National Institute for Health and Care Excellence appraisals of cancer therapy
(Journal article; Peer reviewed, 2022)Introduction Due to the limitations of relying on randomised controlled trials, the potential benefits of real-world data (RWD) in enriching evidence for health technology assessment (HTA) are highlighted. Despite increased ... -
Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors
(Journal article; Peer reviewed, 2021)Tumor organoids and patient-derived orthotopic xenografts (PDOXs) are some of the most valuable pre-clinical tools in cancer research. In this protocol, we describe efficient derivation of organoids and PDOX models from ... -
Proton pump inhibitors in acid-related diseases. Issues in diagnosis, treatment and outcome
(Doctoral thesis, 2013-06-18)Acid-related disease (ARD) is a term used to describe a range of conditions in which acid is involved in the generation of symptoms and/or complications. Two of the most common ARDs are gastro-esophageal reflux disease ... -
Providing emergency care and assessing a patient triage system in a referral hospital in Somaliland: a cross-sectional study
(Peer reviewed; Journal article, 2014-11-06)Background: In resource-poor settings, where health systems are frequently stretched to their capacity, access to emergency care is often limited. Triage systems have been proposed as a tool to ensure efficiency and optimal ... -
Providing free heroin to addicts participating in research - ethical concerns and the question of voluntariness
(Peer reviewed; Journal article, 2015-02-02)Providing heroin to people with heroin addiction taking part in medical trials assessing the effectiveness of the drug as a treatment alternative breaches ethical research standards, some ethicists maintain. Heroin addicts, ... -
Proximity to vector breeding site and risk of Plasmodium vivax infection: a prospective cohort study in rural Ethiopia
(Peer reviewed; Journal article, 2017-09-19)Background: Despite falling incidence and mortality since the turn of the century, malaria remains an important global health challenge. In the future fight against malaria, greater emphasis will have to be placed on ... -
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression
(Journal article; Peer reviewed, 2022)The progression of cancer from localized to metastatic disease is the primary cause of morbidity and mortality. The interplay between the tumor and its microenvironment is the key driver in this process of tumor progression. ... -
Psoriasis in Norway: A Prescription-based Registry Study of Incidence and Prevalence
(Journal article; Peer reviewed, 2023)Epidemiological data on psoriasis in Norway are limited. The aim of this study was to provide objective national data on the incidence and prevalence of psoriasis. Patients registered in the Norwegian Prescription Database ... -
Psychiatric Comorbidity, Social Aspects and Quality of Life in a Population-Based Cohort of Expecting Fathers with Epilepsy
(Peer reviewed; Journal article, 2015-12-04)Objectives. To investigate psychiatric disorders, adverse social aspects and quality of life in men with epilepsy during partner’s pregnancy. Method. We used data from the Norwegian Mother and Child Cohort Study, including ... -
Psychiatric disease, adverse social aspects, and quality of life in women and men with epilepsy related to pregnancy
(Doctoral thesis, 2016-11-11)Background: Epilepsy occurs in 0.7-1.3 % of the population and affects both genders and all age groups, including women and men of fertile age. Epilepsy is an important cause of disability with consequences for work ... -
Psychiatric disorders in children with cerebral palsy. Is there a need for mental health screening?
(Doctoral thesis, 2015-06-12)Cerebral palsy (CP) is one of the most prevalent neuro-motor disorders in childhood. Previous studies using mental health questionnaires, had found mental health problems in up to every second child with CP. Peer problems ... -
Psychiatric disorders, quality of life and effect of preoperative counselling in patients who undergo bariatric surgery
(Doctoral thesis, 2012-02-24)Background: Bariatric surgery is increasingly recommended as the treatment of choice for patients with severe obesity (BMI >40 kg/m2 or BMI >35 kg/m2 and a serious comorbid somatic condition). Surgical success, which ... -
Psychiatric patients’ attitudes towards being hospitalized: a national multicentre study in Norway
(Journal article; Peer reviewed, 2022-11-21)Background: The aim of the study was to explore patients’ attitudes towards voluntary and involuntary hospitalization in Norway, and predictors for involuntary patients who wanted admission. Methods: A multi-centre study ... -
Psychiatry out-of-hours: a focus group study of GPs’ experiences in Norwegian casualty clinics
(Peer reviewed; Journal article, 2011-05-27)Background: For Norwegian general practitioners (GPs), acute treatment of mental illness and substance abuse are among the most commonly experienced emergency situations in out-of-hours primary healthcare. The largest share ... -
Psychoactive drugs in seven nursing homes
(Peer reviewed; Journal article, 2012-07)Aims: We wanted to pinpoint any differences in treatment between participating nursing homes, investigate which drugs are currently prescribed most frequently for long-term patients in nursing homes, estimate prevalence ...