Blar i Department of Biomedicine på forfatter "Saraste, Jaakko"
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Assembly and Cellular Exit of Coronaviruses: Hijacking an Unconventional Secretory Pathway from the Pre-Golgi Intermediate Compartment via the Golgi Ribbon to the Extracellular Space
Saraste, Jaakko; Prydz, Kristian (Journal article; Peer reviewed, 2021)Coronaviruses (CoVs) assemble by budding into the lumen of the intermediate compartment (IC) at the endoplasmic reticulum (ER)-Golgi interface. However, why CoVs have chosen the IC as their intracellular site of assembly ... -
Editorial: Golgi Dynamics in Physiological and Pathological Conditions
Prydz, Kristian; Lupashin, Vladimir; Wang, Yanzhuang; Saraste, Jaakko (Journal article; Peer reviewed, 2020-01-29) -
Evidence for the role of Rab11-positive recycling endosomes as intermediates in coronavirus egress from epithelial cells
Saraste, Jaakko; Enyioko, Mary; Dale, Hege Avsnes; Prydz, Kristian; Machamer, Carolyn (Journal article; Peer reviewed, 2022)After their assembly by budding into the lumen of the intermediate compartment (IC) at the endoplasmic reticulum (ER)–Golgi interface, coronaviruses (CoVs) are released from their host cells following a pathway that remains ... -
The life cycle and enigmatic egress of coronaviruses
Prydz, Kristian; Saraste, Jaakko (Journal article; Peer reviewed, 2022)There has been considerable recent interest in the life cycle of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent of the Covid-19 pandemic. Practically every step in CoV replication—from ... -
N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus
Beigl, Tobias; Hellesvik, Monica; Saraste, Jaakko; Arnesen, Thomas; Aksnes, Henriette (Journal article; Peer reviewed, 2020)N-alpha-acetyltransferase 80 (NAA80) was recently demonstrated to acetylate the N-terminus of actin, with NAA80 knockout cells showing actin cytoskeleton-related phenotypes, such as increased formation of membrane protrusions ... -
A New Look at the Functional Organization of the Golgi Ribbon
Saraste, Jaakko; Prydz, Kristian (Peer reviewed; Journal article, 2019-08-21)A characteristic feature of vertebrate cells is a Golgi ribbon consisting of multiple cisternal stacks connected into a single-copy organelle next to the centrosome. Despite numerous studies, the mechanisms that link the ... -
Phosphorylation at serine 31 targets tyrosine hydroxylase tovesicles for transport along microtubules
Jorge Finnigan, Ana; Kleppe, Rune; K C, Kunwar Jung; Ying, Ming; Marie, Michael Bruno Eric; Rios Mondragon, Ivan; Salvatore, Michael F; Saraste, Jaakko; Martinez, Aurora (Peer reviewed; Journal article, 2017)Tyrosine hydroxylase (TH) catalyzes the conversion of L-tyrosine into L-DOPA, which is the rate-limiting step in the synthesis of catecholamines, such as dopamine, in dopaminergergic neurons. Low dopamine levels and death ... -
PKU mutation p.G46S prevents the stereospecific binding of l-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain
Leandro, João; Saraste, Jaakko; Leandro, Paula; Flatmark, Torgeir (Peer reviewed; Journal article, 2017-02)Mammalian phenylalanine hydroxylase (PAH) has a potential allosteric regulatory binding site for l‐phenylalanine (l‐Phe), in addition to its catalytic site. This arrangement is supported by a crystal structure of a homodimeric ... -
Post-translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes
Aukrust, Ingvild; Rosenberg, Linn Andersen; Ankerud, Mia Madeleine; Bertelsen, Vibeke; Hollås, Hanne; Saraste, Jaakko; Grindheim, Ann Kari; Vedeler, Anni (Peer reviewed; Journal article, 2017-02)Various post-translational modifications (PTMs) regulate the localisation and function of the multifunctional protein Annexin A2 (AnxA2). In addition to its various tasks as a cytoskeletal- and membrane-associated protein, ... -
Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of Annexin A2
Grindheim, Ann Kari; Hollås, Hanne; Raddum, Aase Merethe; Saraste, Jaakko; Vedeler, Anni (Peer reviewed; Journal article, 2015-01-15)Annexin A2 (AnxA2) is a multi-functional and -compartmental protein whose subcellular localisation and functions are tightly regulated by its post-translational modifications. AnxA2 and its Tyr23-phosphorylated form ... -
Subcellular Distribution of BALF2 and the Role of Rab1 in the Formation of Epstein-Barr Virus Cytoplasmic Assembly Compartment and Virion Release
Chao, Tsung-Yu; Cheng, Yi-Ying; Wang, Zi-Yun; Fang, Tien-Fang; Chang, Yu-Ruei; Fuh, Chi-Shane; Su, Mei-Tzu; Su, Yuan-Wei; Hsu, Pang-Hung; Su, Yu-Chen; Chang, Yu-Ching; Lee, Ting-Yau; Chou, Wei-Han; Middeldorp, Jaap M.; Saraste, Jaakko; Chen, Mei-Ru (Journal article; Peer reviewed, 2023)Epstein-Barr virus (EBV) replicates its genome in the nucleus and undergoes tegumentation and envelopment in the cytoplasm. We are interested in how the single-stranded DNA binding protein BALF2, which executes its function ...