Blar i Department of Clinical Medicine på tittel
Viser treff 1310-1329 av 2095
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Microvascular proliferation is associated with aggressive tumour features and reduced survival in lung adenocarcinoma
(Peer reviewed; Journal article, 2017-10)Despite new treatment options in lung cancer, there is still a need for better biomarkers to assist in therapy decisions. Angiogenesis has been associated with tumour growth and dissemination, and the vascular proliferation ... -
Microvascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer
(Journal article; Peer reviewed, 2023)Active angiogenesis may be assessed by immunohistochemistry using Nestin, a marker of newly formed vessels, combined with Ki67 for proliferating cells. Here, we studied microvascular proliferation by Nestin-Ki67 co-expression ... -
Minimal important change was on the lower spectrum of previous estimates and responsiveness was sufficient for core outcomes in chronic low back pain
(Journal article; Peer reviewed, 2022)Objectives: The objective of this study was to estimate the minimal important change (MIC) and responsiveness of core patient reported outcome measures for chronic low back pain (LBP) and Modic changes. Study Design and ... -
Minimally invasive pancreatic surgery-where are we going?
(Peer reviewed; Journal article, 2019-03-13)Background Introduced in the mid-1990s, minimally invasive pancreatic surgery (MIPS) developed slowly over the next two decades, and its real-life benefits remained unclear. Methods In this review, the current status and ... -
Minimally Invasive Pancreatoduodenectomy: Contemporary Practice, Evidence, and Knowledge Gaps
(Journal article; Peer reviewed, 2022)Minimally invasive pancreatoduodenectomy has gained popularity throughout the last decade. For laparoscopic pancreatoduodenectomy, some high-level evidence exists, but with conflicting results. There are currently no ... -
Mitochondrial biomarkers and biomarkers of mitochondrial disease
(Doctoral thesis, 2021-11-26)Background: Biomarkers are objective and reproducible tools that are essential for making the diagnosis and following disease development in clinical practice. Mitochondria are multifunctional organelles and the major site ... -
Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease
(Journal article; Peer reviewed, 2020)Mitochondrial dysfunction has been implicated in multiple neurodegenerative diseases but remains largely unexplored in Creutzfeldt-Jakob disease. Here, we characterize the mitochondrial respiratory chain at the individual ... -
Mitochondrial respiratory chain dysfunction—A hallmark pathology of idiopathic Parkinson’s disease?
(Journal article; Peer reviewed, 2022)Parkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of ... -
Mitokondriesykdom forårsaket av m.3243A>G-mutasjonen
(Journal article; Peer reviewed, 2022)Mitokondriesykdom er blant de vanligste metabolske sykdommene og er relevant for mange medisinske spesialiteter. Denne kliniske oversiktsartikkelen omtaler en av de vanligste mutasjonene bak mitokondriesykdom: m.3243A>G. ... -
Modic changes-Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis
(Peer reviewed; Journal article, 2018-08-01)Background: Previous systematic reviews have reported positive associations between Modic changes (MCs) and low back pain (LBP), but due to their narrow scope and new primary studies, there is a need for a comprehensive ... -
Modifiable and non-modifiable risk factors in hip fracture mortality in Norway, 2014 to 2018 - a linked multiregistry study
(Journal article; Peer reviewed, 2022)Aims This study aimed to identify risk factors (patient, healthcare system, and socioeconomic) for mortality after hip fractures and estimate their relative importance. Further, we aimed to elucidate mortality and survival ... -
Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells
(Journal article; Peer reviewed, 2021)Prostate cancer (PCa) is the most common non-cutaneous cancer in men and a notable cause of cancer mortality when it metastasises. The unfolded protein response (UPR) can be cytoprotective but when acutely activated can ... -
Molecular approaches to the diagnosis and evaluation of follicular lymphoma
(Doctoral thesis, 2015-05-27)Background: Molecular studies of immunoglobulin (IG) genes have provided insights into the pathogenesis of different lymphoid malignancies and allowed the development of useful diagnostic tools as well as powerful prognostic ... -
Molecular biology in pancreatic ductal adenocarcinoma: implications for future diagnostics and therapy
(Peer reviewed; Journal article, 2019)Background: Novel technology has enabled researchers to better characterize pancreatic cancers at the molecular level. We wanted to explore some of the emerging discoveries, such as molecular subclassification, use of ... -
Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer
(Peer reviewed; Journal article, 2012)We characterized tumor microenvironment (TME) components of mobile tongue (MT) cancer patients in terms of overall inflammatory infiltrate, focusing on the protumorigenic/anti-inflammatory phenotypes and on cancer-associated ... -
Molecular dysfunction associated with the human mitochondrial 3302A>G mutation in the MTTL1 (mt-tRNA Leu(UUR))) gene
(Peer reviewed; Journal article, 2006-11-27)The gene encoding mt-tRNALeu(UUR), MT-TL1, is a hotspot for pathogenic mtDNA mutations. Amongst the first to be described was the 3302A>G transition which resulted in a substantial accumulation in patient muscle of RNA19, ... -
Molecular mechanisms of mitochondrial dysfunction in neurodegenerative diseases
(Doctoral thesis, 2024-06-05)Bakgrunn Nevrodegenerative lidelser er komplekse lidelser i sentralnervesystemet som er typisk preget av akkumulering av feilfoldede proteiner og progressiv degenerasjon og død av sårbare cellepopulasjoner i de berørte ... -
Molecular pathogenesis of polymerase gamma-related neurodegeneration
(Peer reviewed; Journal article, 2014-07)Objective: Polymerase gamma (POLG) mutations are a common cause of mitochondrial disease and have also been linked to neurodegeneration and aging. We studied the molecular mechanisms underlying POLG-related neurodegeneration ... -
Molecular subtypes in stage II-III colon cancer defined by genomic instability: Early recurrence-risk associated with a high copy-number variation and loss of RUNX3 and CDKN2A
(Peer reviewed; Journal article, 2015-04-16)Objective: We sought to investigate various molecular subtypes defined by genomic instability that may be related to early death and recurrence in colon cancer. Methods: We sought to investigate various molecular subtypes ...