Browsing Department of Clinical Medicine by Journals "Scientific Reports"

Now showing items 1-20 of 26

    • Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination 

      Eide, Thea Tislevoll; Hufthammer, Karl Ove; Brun, Atle; Brackman, Damien; Svarstad, Einar; Tøndel, Camilla (Journal article; Peer reviewed, 2021)
      Measurement of glomerular filtration rate (GFR) in children by iohexol injection and blood sampling from the contralateral arm is widely used. A single intravenous access for iohexol injection and subsequent blood sampling ...

    • AChR antibodies show a complex interaction with human skeletal muscle cells in a transcriptomic study 

      Hong, Yu; Liang, Kristina Xiao; Gilhus, Nils Erik (Journal article; Peer reviewed, 2020-07-08)
      Acetylcholine receptor (AChR) antibodies are the most important pathogenic marker in patients with myasthenia gravis (MG). The antibodies bind to AChRs on the postsynaptic membrane, and this leads to receptor degradation, ...

    • Automated segmentation of endometrial cancer on MR images using deep learning 

      Hodneland, Erlend; Dybvik, Julie Andrea; Wagner-Larsen, Kari Strøno; Solteszova, Veronika; Zanna, Antonella; Fasmer, Kristine Eldevik; Krakstad, Camilla; Lundervold, Arvid; Lundervold, Alexander Selvikvåg; Salvesen, Øyvind; Erickson, Bradley J.; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2021)
      Preoperative MR imaging in endometrial cancer patients provides valuable information on local tumor extent, which routinely guides choice of surgical procedure and adjuvant therapy. Furthermore, whole-volume tumor analyses ...

    • Baseline microvessel density predicts response to neoadjuvant bevacizumab treatment of locally advanced breast cancer 

      Krüger, Kristi; Silwal-Pandit, Laxmi; Wik, Elisabeth; Straume, Oddbjørn; Stefansson, Ingunn Marie; Borgen, Elin; Garred, Øystein; Naume, Bjørn; Engebråten, Olav; Akslen, Lars Andreas (Journal article; Peer reviewed, 2021)
      A subset of breast cancer patients benefits from preoperative bevacizumab and chemotherapy, but validated predictive biomarkers are lacking. Here, we aimed to evaluate tissue-based angiogenesis markers for potential ...

    • Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling 

      Pettersen, Kristine; Andersen, Sonja Benedikte; Degen, simone; Tadini, Valentina; Grosjean, Joel; Hatakeyama, Shinji; Tesfahun, Almaz Nigatu; Moestue, Siver Andreas; Kim, Jana; Nonstad, Unni; Romundstad, Pål Richard; Skorpen, Frank; Sørhaug, Sveinung; Amundsen, Tore; Grønberg, Bjørn Henning; Strasser, Florian; Stephens, Nathan; Hoem, Dag; Molven, Anders; Kaasa, Stein; Fearon, Kenneth; Jacobi, Carsten; Bjørkøy, Geir (Peer reviewed; Journal article, 2017-05-17)
      The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional ...

    • Comparison of nutritional risk screening with NRS2002 and the GLIM diagnostic criteria for malnutrition in hospitalized patients 

      Trollebø, Marte Almenning; Skeie, Eli; Revheim, Ingrid; Stangeland, Helene; Erstein, Mari-Anne Heggelien; Grønning, Martin Kristoffer; Tangvik, Randi Julie; Morken, Mette Helvik; Nygård, Ottar Kjell; Eagan, Tomas Mikal Lind; Rosendahl-Riise, Hanne; Dierkes, Jutta (Journal article; Peer reviewed, 2022)
      Nutritional risk screening, to identify patients at risk of malnutrition, is the first step in the prevention and treatment of malnutrition in hospitalized patients, and should be followed by a thorough nutritional assessment ...

    • Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement 

      Vigeland, Maria Dehli; Flåm, Siri Tennebø; Vigeland, Magnus Dehli; Espeland, Ansgar; Kristoffersen, Per Martin; Vetti, Nils; Wigemyr, Monica; Bråten, Lars Christian Haugli; Gjefsen, Elisabeth; Schistad, Ellina Iordanova; Haugen, Anne Julsrud; Johanessen, Anne Froholdt; Skouen, Jan Sture; Zwart, John Anker Henrik; Storheim, Kjersti; Pedersen, Linda Margareth; Lie, Benedicte Alexandra (Journal article; Peer reviewed, 2022-01-07)
      Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifiable by MRI ...

    • Extracellular DNA concentrations in various aetiologies of acute kidney injury 

      Gaál Kovalčíková, Alexandra; Janovičová, Ľubica; Hodosy, Július; Babickova, Janka; Vavrincová-Yaghi, Diana; Vavrinec, Peter; Boor, Peter; Podracká, Ľudmila; Šebeková, Katarína; Celec, Peter; Tóthová, Ľubomíra (Journal article; Peer reviewed, 2022)
      Extracellular DNA (ecDNA) in plasma is a non-specific biomarker of tissue damage. Urinary ecDNA, especially of mitochondrial origin, is a potential non-invasive biomarker of kidney damage. Despite prominent tissue damage, ...

    • GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study 

      Rongve, Arvid; Witoelar, Aree; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla; Clarimon, Jordi; Heilmann-Heimbach, Stefanie; Hernández, Isabel; Moreno-Grau, Sonia; de Rojas, Itziar; Morenas-Rodríguez, Estrella; Fladby, Tormod; Sando, Sigrid Botne; Bråthen, Geir; Blanc, Frédéric; Bousiges, Olivier; Lemstra, Afina W.; van Steenoven, Inger; Londos, Elisabet; Almdahl, Ina Selseth; Pålhaugen, Lene; Eriksen, Jon Alm; Djurovic, Srdjan; Stordal, Eystein; Saltvedt, Ingvild; Ulstein, Ingun; Bettella, Francesco; Desikan, Rahul S.; Idland, Ane-Victoria; Toft, Mathias; Pihlstrøm, Lasse; Snaedal, Jon; Tárraga, Lluís; Boada, Mercè; Lleó, Alberto; Stefánsson, Hreinn; Stefánsson, Kári; Ramírez, Alfredo; Aarsland, Dag; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2019-05-07)
      Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we ...

    • Gene expression alterations in salivary gland epithelia of Sjögren’s syndrome patients are associated with clinical and histopathological manifestations 

      Dela Cruz, Ariana; Kartha, Vinay; Tilston-Lunel, Andrew; Mi, Rongjuan; Reynolds, Taylor L.; Mingueneau, Michael; Monti, Stefano; Jensen, Janicke Liaaen; Skarstein, Kathrine; Varelas, Xaralabos; Kukuruzinska, Maria A. (Journal article; Peer reviewed, 2021)
      Sjögren’s syndrome (SS) is a complex autoimmune disease associated with lymphocytic infiltration and secretory dysfunction of salivary and lacrimal glands. Although the etiology of SS remains unclear, evidence suggests ...

    • Helicobacter pylori was not detected in oral squamous cell carcinomas from cohorts of Norwegian and Nepalese patients 

      Pandey, Sushma; Follin-Arbelet, Benoit; Bahadur Pun, Chin; K. Gautam, Dej; Johannessen, Anne Christine; Petersen, Fernanda Cristina; Costea, Daniela Elena; Sapkota, Dipak (Journal article; Peer reviewed, 2020)
      Helicobacter pylori (HP) infection is an established causative agent for gastric cancer. Although the oral cavity is a part of the gastrointestinal system, the presence and possible causative role of HP in oral squamous ...

    • High expression of miR‑17‑5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients 

      Støen, Maria Jenvin; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona Irene; Ingebriktsen, Lise Martine; Bremnes, Roy M.; Dønnem, Tom; Lombardi, Ana Paola; Kilvær, Thomas Karsten; Rasmussen Busund, Lill-Tove; Richardsen, Elin (Journal article; Peer reviewed, 2021)
      MicroRNAs (miRs) are small non-coding RNA molecules, which are involved in the development of various malignancies, including prostate cancer (PCa). miR-17-5p is considered the most prominent member of the miR-17-92 cluster, ...

    • Improvement of storage medium for cultured human retinal pigment epithelial cells using factorial design 

      Pasovic, Lara; Utheim, Tor Paaske; Reppe, Sjur; Khan, Ayyad Ahmad Zartasht; Jackson, Catherine; Thiede, Bernd; Berg, Jens Petter; Messelt, Edvard Berger; Eidet, Jon Roger (Peer reviewed; Journal article, 2018-04-09)
      Storage of human retinal pigment epithelium (hRPE) can contribute to the advancement of cell-based RPE replacement therapies. The present study aimed to improve the quality of stored hRPE cultures by identifying storage ...

    • Influence of circulatory shock at hospital admission on outcome after out-of-hospital cardiac arrest 

      Düring, Joachim; Annborn, Martin; Dankiewicz, Josef; Dupont, Allison; Forsberg, Sune; Friberg, Hans; Kern, Karl B.; May, Teresa L.; McPherson, John; Patel, Nainesh; Seder, David B.; Stammet, Pascal; Sunde, Kjetil; Søreide, Eldar; Ullén, Susann; Nielsen, Niklas (Journal article; Peer reviewed, 2022)
      Hypotension after cardiac arrest could aggravate prolonged hypoxic ischemic encephalopathy. The association of circulatory shock at hospital admission with outcome after cardiac arrest has not been well studied. The objective ...

    • Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci 

      Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2018-12-27)
      A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ...

    • A method for dierentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96‐well microplates 

      Balafkan, Novin; Mostafavi, Sepideh; Schubert, Manja; Siller, Richard; Liang, Xiao; Sullivan, Gareth; Bindoff, Laurence (Journal article; Peer reviewed, 2020)
      The capacity of pluripotent stem cells both for self-renewal and to differentiate into any cell type have made them a powerful tool for studying human disease. Protocols for efficient differentiation towards cardiomyocytes ...

    • Microvascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer 

      Børretzen, Astrid; Reisæter, Lars Anders Rokne; Ringheim, Anders; Gravdal, Karsten; Haukaas, Svein Andreas; Fasmer, Kristine Eldevik; Haldorsen, Ingfrid S.; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2023)
      Active angiogenesis may be assessed by immunohistochemistry using Nestin, a marker of newly formed vessels, combined with Ki67 for proliferating cells. Here, we studied microvascular proliferation by Nestin-Ki67 co-expression ...

    • Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells 

      Amoroso, Francesca; Glass, Kimberley; Singh, Reema; Liberal, Francisco; Steele, Rebecca E.; Maguire, Sarah; Tarapore, Rohinton; Allen, Joshua E.; Van Schaeybroeck, Sandra; Butterworth, Karl T.; Prise, Kevin; O’Sullivan, Joe M.; Jain, Suneil; Waugh, David J.; Mills, Ian (Journal article; Peer reviewed, 2021)
      Prostate cancer (PCa) is the most common non-cutaneous cancer in men and a notable cause of cancer mortality when it metastasises. The unfolded protein response (UPR) can be cytoprotective but when acutely activated can ...

    • A multiomics disease progression signature of low-risk ccRCC 

      Strauss, Philipp; Rivedal, Mariell; Scherer, Andreas; Eikrem, Øystein Solberg; Nakken, Sigrid; Beisland, Christian; Bostad, Leif; Flatberg, Arnar; Skandalou, Eleni; Beisvag, Vidar; Furriol, Jessica; Marti, Hans Peter (Journal article; Peer reviewed, 2022)
      Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer. Identification of ccRCC likely to progress, despite an apparent low risk at the time of surgery, represents a key clinical issue. From a cohort of ...

    • Novel hybridization- and tag-based error-corrected method for sensitive ctDNA mutation detection using ion semiconductor sequencing 

      Tjensvoll, Kjersti; Lapin, Morten; Gilje, Bjørnar; Garresori, Herish; Oltedal, Satu; Forthun, Rakel Brendsdal; Molven, Anders; Rozenholc, Yves; Nordgård, Oddmund (Journal article; Peer reviewed, 2022)
      Circulating tumor DNA (ctDNA) analysis has emerged as a clinically useful tool for cancer diagnostics and treatment monitoring. However, ctDNA detection is complicated by low DNA concentrations and technical challenges. ...