Browsing Department of Chemistry by Title
Now showing items 113-132 of 449
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Development of an extraction method for the analysis of pro-inflammatory prostaglandin-E2 and leukotriene-B4 in human plasma by liquid chromatography tandem mass spectrometry
(Master thesis, 2013-02-21)A simple and rapid method for extracting PGE2 and LTB4 from human plasma and further determination by LC-MS/MS proposed and validated. Extracting solvents, formic acid (10 µL) and acetonitrile (140 µL) were added subsequently ... -
Development of an imaging method for in vivo single-cell tracking under high-noise conditions: a proof of principle
(Journal article; Peer reviewed, 2023)This paper reports the development of a positron imaging method for in vivo single-cell tracking under high-noise conditions. Following biological processes spatially and temporally at a single-cell level in a living ... -
Development of Endothelial Barrier Models for Nanotoxicity Testing
(Master thesis, 2022-02-07)Nanotechnology is a field of both research and innovation that is ever-growing. It Is the study and manipulation of matter at the nanoscale to produce materials and devices with enhanced properties. Industries are spending ... -
Development of Methodology for the Synthesis of Cytotoxic NHC-Ag-Complexes
(Master thesis, 2016-06-02)Recently disclosed silver N-heterocyclic carbene complexes holding 4-alkylated imidazoles have been proved to hold cytotoxic properties. In this work, derivatives of such alkylated imidazoles were synthesised to be complexed ... -
Development of methods based on NIR and Raman spectroscopies together with chemometric tools for the qualitative and quantitative analysis of gasoline
(Master thesis, 2019-09-28)Gasoline quality control is essential for SI engines performance and to reduce environmental impacts by generation of undesirable pollutants. Methods established by the American Society for Test and Materials (ASTM) are ... -
Development of Small Molecules that Post-Transitionally Stabilizes the SMN Protein for the Treatment of Spinal Muscular Atrophy
(Master thesis, 2019-08-31)Spinal Muscular Atrophy is an autosomal recessive neurodegenerative disorder, caused by the lack of SMN genes. Previous work done by Laboratory for Drug Discovery in Neurodegeneration (LDDN) at Brigham and Women’s Hospital ... -
Development, validation and application of in-silico methods to predict the macromolecular targets of small organic compounds
(Doctoral thesis, 2021-12-10)Computational methods to predict the macromolecular targets of small organic drugs and drug-like compounds play a key role in early drug discovery and drug repurposing efforts. These methods are developed by building ... -
Di-μ-chlorido-bis{bis[N,N-bis(trimethylsilyl)amido]titanium(III)}
(Journal article; Peer reviewed, 2017)The molecular structure of the title compound, [Ti2Cl2(C6H18NSi2)4], shows a binuclear motif of TiIII atoms, formulated as [Ti(μ-Cl)(N(SiMe3)2)2]2, with two μ-Cl atoms bridging two ((Me3Si)2N)2Ti moieties. The coordination ... -
Diels-Alder reactions with 1,1-diethoxybut-3-yn-2-one and some 1,1-diethoxy-5-hydroxyalk-3-yn-2-ones and their acetates
(Journal article; Peer reviewed, 2020) -
Dimethyl 3,3′-dimethoxybiphenyl-4,4′-dicarboxylate
(Peer reviewed; Journal article, 2014)In the title compound, C18H18O6, the biphenyl moiety is twisted with a dihedral angle of 29.11 (10)°. The carbomethoxy groups form C-C-C-O torsion angles of -18.3 (3) and -27.7 (3)° with the attached rings, as a result ... -
Direct Injection Electrospray Mass Spectrometry (DI-ESI-MS) and Liquid Chromatography Electrospray Mass Spectrometry (LC-ESI-MS) method development for characterisation of organic acids in petroleum and bio-oil samples
(Master thesis, 2017-05-09)Analysis and characterisation of complex mixtures such as petroleum and bio-oils are unarguably challenging. Finding suitable analytical method therefore needs to be considered carefully by analytical chemists. Electrospray ... -
Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1,4-dimethylphenanthrene
(Journal article; Peer reviewed, 2024)Most of the polycyclic aromatic hydrocarbons (PAHs) in petroleum are alkylated (alkyl PAHs), still the metabolism of these alkyl PAHs to the expected acid products (polycyclic aromatic acids; PAAs) has yet to be demonstrated ... -
Discrimination of n-3 Rich Oils by Gas Chromatography
(Peer reviewed; Journal article, 2010-11-22)Exploring the capabilities of instrumental techniques for discriminating n-3 rich oils derived from animals is a very important though much neglected area that was emphasized more than 100 years ago. In this study the ... -
Dissecting peripheral protein-membrane interfaces
(Journal article; Peer reviewed, 2022-12-14)Peripheral membrane proteins (PMPs) include a wide variety of proteins that have in common to bind transiently to the chemically complex interfacial region of membranes through their interfacial binding site (IBS). In ... -
DMAEMA-grafted cellulose as an imprinted adsorbent for the selective adsorption of 4-nitrophenol
(Journal article; Peer reviewed, 2021)4-Nitrophenol is a highly toxic environmental pollutant. It is a challenge to selectively remove it from a mixture of various pollutants. Herein, we report a study on the selective adsorption of 4-nitrophenol by using ... -
Does high offshore petroleum activity affect the lipid composition in wild Atlantic Cod (Gadus morhua) from the North Sea?
(Master thesis, 2012-03-12)A combined two step extraction, using hexane/methanol to extract neutral lipids and chloroform/methanol to extract polar lipids, has been developed and validation. Four times methanol wash were done to hexane/methanol ... -
Easily Achievable Methods for Making Superamphiphobic Surfaces
(Master thesis, 2018-06-27)Superamphiphobic materials have surfaces that display a contact angle above 150° for both low and high-tension liquids [1]. Superamphiphobic surfaces present exciting and innovative properties for commercial and industrial ... -
Effect of initial water flooding on the performance of polymer flooding for heavy oil production
(Journal article; Peer reviewed, 2020)In the domain of heavy to extra heavy oil production, viscous polymer may be injected after water injection (tertiary mode), or as an alternative (secondary mode) to improve the sweep efficiency and increase oil recovery. ... -
The effect of input material pretreatment on product yield and composition of bio-oils from LtL-solvolysis. A continuous process for organosolv fractionation of lignocellulosic biomass and solvolytic conversion of lignin
(Doctoral thesis, 2017-01-27)As the world’s population and subsequent energy demand increases, there is a need to supplement existing energy technology with new and alternative approaches. Lignocellulosic biomass represents the vast bulk of terrestrial ... -
Effect of Larger Pore Size on the Sorption Properties of Isoreticular Metal–Organic Frameworks with High Number of Open Metal Sites
(Journal article; Peer reviewed, 2020)Four isostructural CPO‐54‐M metal‐organic frameworks based on the larger organic linker 1,5‐dihydroxynaphthalene‐2,6‐dicarboxylic acid and divalent cations (M=Mn, Mg, Ni, Co) are shown to be isoreticular to the CPO‐27 ...