Browsing Sars International Centre for Marine Molecular Biology by Title
Now showing items 12-31 of 131
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Characterization of Schistosoma mansoni Glutamate-Gated Chloride Channels
(Journal article; Peer reviewed, 2020)Electrophysiology is the standard method for characterizing ion channel function. Two-electrode voltage clamp is a robust and relatively simple version which can be applied to the characterization of glutamate-gated chloride ... -
Choanoflagellates and the ancestry of neurosecretory vesicles
(Journal article; Peer reviewed, 2021)Neurosecretory vesicles are highly specialized trafficking organelles that store neurotransmitters that are released at presynaptic nerve endings and are, therefore, important for animal cell–cell signalling. Despite ... -
Chromatin jets define the properties of cohesin-driven in vivo loop extrusion
(Journal article; Peer reviewed, 2022)Complex genomes show intricate organization in three-dimensional (3D) nuclear space. Current models posit that cohesin extrudes loops to form self-interacting domains delimited by the DNA binding protein CTCF. Here, we ... -
Ciliary photoreceptors in the cerebral eyes of a protostome larva
(Peer reviewed; Journal article, 2011-03-01)Background: Eyes in bilaterian metazoans have been described as being composed of either ciliary or rhabdomeric photoreceptors. Phylogenetic distribution, as well as distinct morphologies and characteristic deployment of ... -
Ciona spp. and ascidians as bioindicator organisms for evaluating effects of endocrine disrupting chemicals: A discussion paper
(Journal article; Peer reviewed, 2023)In context of testing, screening and monitoring of endocrine-disrupting (ED) type of environmental pollutants, tunicates could possibly represent a particularly interesting group of bioindicator organisms. These primitive ... -
cis–regulation and mis–regulation – Insights into genomic regulatory mechanisms underlying the control of fgf8a in zebrafish Danio rerio
(Doctoral thesis, 2008-06-19)Fibroblast growth factor 8 (Fgf8) is a potent vertebrate morphogen that plays decisive roles in multiple developmental processes, such as cellular proliferation, survival, differentiation, growth and migration. Fgf8 ... -
Cleavage modification did not alter blastomere fates during bryozoan evolution
(Journal article; Peer reviewed, 2017-04-28)Background: Stereotypic cleavage patterns play a crucial role in cell fate determination by precisely positioning early embryonic blastomeres. Although misplaced cell divisions can alter blastomere fates and cause embryonic ... -
CNEr: A toolkit for exploring extreme noncoding conservation
(Journal article; Peer reviewed, 2019-08-26)Conserved Noncoding Elements (CNEs) are elements exhibiting extreme noncoding conservation in Metazoan genomes. They cluster around developmental genes and act as long-range enhancers, yet nothing that we know about their ... -
Cnidofest 2022: hot topics in cnidarian research
(Journal article; Peer reviewed, 2023-08-24)The second annual Cnidarian Model Systems Meeting, aka “Cnidofest”, took place in Davis, California from 7 to 10th of September, 2022. The meeting brought together scientists using cnidarians to study molecular and cellular ... -
Comparative Animal Mucomics: Inspiration for Functional Materials from Ubiquitous and Understudied Biopolymers
(Journal article; Peer reviewed, 2020)The functions of secreted animal mucuses are remarkably diverse and include lubricants, wet adhesives, protective barriers, and mineralizing agents. Although present in all animals, many open questions related to the ... -
Comprehensive analysis of locomotion dynamics in the protochordate Ciona intestinalis reveals how neuromodulators flexibly shape its behavioral repertoire
(Journal article; Peer reviewed, 2022)Vertebrate nervous systems can generate a remarkable diversity of behaviors. However, our understanding of how behaviors may have evolved in the chordate lineage is limited by the lack of neuroethological studies leveraging ... -
Conservative route to genome compaction in a miniature annelid
(Journal article; Peer reviewed, 2021)The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact ... -
Coordinated spatial and temporal expression of Hox genes during embryogenesis in the acoel Convolutriloba longifissura
(Journal article; Peer reviewed, 2009-10-01)Background: Hox genes are critical for patterning the bilaterian anterior-posterior axis. The evolution of their clustered genomic arrangement and ancestral function has been debated since their discovery. As acoels appear ... -
Cytoskeleton-mediated templating of complex cellulose-scaffolded extracellular structure and its association with oikosins in the urochordate Oikopleura
(Peer reviewed; Journal article, 2010)Oriented cellulose deposition is critical to plant patterning and models suggest microtubules constrain cellulose synthase movements through the plasma membrane. Though widespread in plants, urochordates are the only animals ... -
A deep learning method for replicate-based analysis of chromosome conformation contacts using Siamese neural networks
(Journal article; Peer reviewed, 2023)The organisation of the genome in nuclear space is an important frontier of biology. Chromosome conformation capture methods such as Hi-C and Micro-C produce genome-wide chromatin contact maps that provide rich data ... -
Detailed reconstruction of the musculature in Limnognathia maerski (Micrognathozoa) and comparison with other Gnathifera
(Journal article; Peer reviewed, 2014-10-01)Introduction: Limnognathia maerski is the single species of the recently described taxon, Micrognathozoa. The most conspicuous character of this animal is the complex set of jaws, which resembles an even more intricate ... -
Development and juvenile anatomy of the nemertodermatid Meara stichopi (Bock) Westblad 1949 (Acoelomorpha)
(Journal article; Peer reviewed, 2014-07-07)Introduction: Nemertodermatida is the sister group of the Acoela, which together form the Acoelomorpha, a taxon that comprises bilaterally symmetric, small aquatic worms. While there are several descriptions of the embryology ... -
The development of early pioneer neurons in the annelid Malacoceros fuliginosus
(Journal article; Peer reviewed, 2020)Background Nervous system development is an interplay of many processes: the formation of individual neurons, which depends on whole-body and local patterning processes, and the coordinated growth of neurites and synapse ... -
Development of the aboral domain in Nematostella requires β-catenin and the opposing activities of Six3/6 and Frizzled5/8
(Journal article; Peer reviewed, 2016-03)The development of the oral pole in cnidarians and the posterior pole in bilaterians is regulated by canonical Wnt signaling, whereas a set of transcription factors, including Six3/6 and FoxQ2, controls aboral development ... -
Development of the larval anterior neurogenic domains of Terebratalia transversa (Brachiopoda) provides insights into the diversification of larval apical organs and the spiralian nervous system
(Peer reviewed; Journal article, 2012-01-24)Background: Larval features such as the apical organ, apical ciliary tuft, and ciliated bands often complicate the evaluation of hypotheses regarding the origin of the adult bilaterian nervous system. Understanding how ...