Browsing Sars International Centre for Marine Molecular Biology by Title
Now showing items 103-122 of 136
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Peptide Inhibitors of the α‑Cobratoxin−Nicotinic Acetylcholine Receptor Interaction
(Journal article; Peer reviewed, 2020)Venomous snakebites cause >100 000 deaths every year, in many cases via potent depression of human neuromuscular signaling by snake α-neurotoxins. Emergency therapy still relies on antibody-based antivenom, hampered by ... -
Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians
(Journal article; Peer reviewed, 2015-12-22)Background: Development of cerebral eyes is generally based on fine-tuned networks and closely intertwined with the formation of brain and head. Consistently and best studied in insects and vertebrates, many signaling ... -
The Potent Respiratory System of Osedax mucofloris (Siboglinidae, Annelida) - A Prerequisite for the Origin of Bone-Eating Osedax?
(Peer reviewed; Journal article, 2012-04-25)Members of the conspicuous bone-eating genus, Osedax, are widely distributed on whale falls in the Pacific and Atlantic Oceans. These gutless annelids contain endosymbiotic heterotrophic bacteria in a branching root system ... -
Prediction of CpG-island function: CpG clustering vs. sliding-window methods
(Peer reviewed; Journal article, 2010-05-26)Background Unmethylated stretches of CpG dinucleotides (CpG islands) are an outstanding property of mammal genomes. Conventionally, these regions are detected by sliding window approaches using %G + C, CpG observed/expected ... -
The premetazoan ancestry of the synaptic toolkit and appearance of first neurons
(Journal article; Peer reviewed, 2022)Neurons, especially when coupled with muscles, allow animals to interact with and navigate through their environment in ways unique to life on earth. Found in all major animal lineages except sponges and placozoans, nervous ... -
Profile analysis and prediction of tissue-specific CpG island methylation classes
(Journal article; Peer reviewed, 2009-04-21)Background: The computational prediction of DNA methylation has become an important topic in the recent years due to its role in the epigenetic control of normal and cancer-related processes. While previous prediction ... -
RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells
(Journal article; Peer reviewed, 2020-03-18)The cardinal virulence factor of human-pathogenic enterohaemorrhagic Escherichia coli (EHEC) is Shiga toxin (Stx), which causes severe extraintestinal complications including kidney failure by damaging renal endothelial ... -
RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions
(Journal article; Peer reviewed, 2020)Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding transcripts exhibit nuclear localization and several have been shown to play a role in the regulation of gene expression and chromatin remodeling. ... -
Recombinant Analogs of Sea Anemone Kunitz-Type Peptides Influence P2X7 Receptor Activity in Neuro-2a Cells
(Journal article; Peer reviewed, 2023)Purinergic P2X7 receptors (P2X7) have now been proven to play an important role and represent an important therapeutic target in many pathological conditions including neurodegeneration. Here, we investigated the impact ... -
Regulation of Nematostella neural progenitors by SoxB, Notch and bHLH genes
(Journal article; Peer reviewed, 2015-10-06)Notch signalling, SoxB and Group A bHLH ‘proneural’ genes are conserved regulators of the neurogenic program in many bilaterians. However, the ancestry of their functions and interactions is not well understood. We address ... -
Regulatory RNA at the root of animals: dynamic expression of developmental lincRNAs in the calcisponge Sycon ciliatum
(Journal article; Peer reviewed, 2015-12-23)Long non-coding RNAs (lncRNAs) play important regulatory roles during animal development, and it has been hypothesized that an RNA-based gene regulation was important for the evolution of developmental complexity in animals. ... -
Retroviral enhancer detection insertions in zebrafish combined with comparative genomics reveal genomic regulatory blocks - a fundamental feature of vertebrate genomes
(Journal article; Peer reviewed, 2007-10-31)A large-scale enhancer detection screen was performed in the zebrafish using a retroviral vector carrying a basal promoter and a fluorescent protein reporter cassette. Analysis of insertional hotspots uncovered areas around ... -
The rhodopsin-retinochrome system for retinal re-isomerization predates the origin of cephalopod eyes
(Journal article; Peer reviewed, 2021-11-29)Background: The process of photoreception in most animals depends on the light induced isomerization of the chromophore retinal, bound to rhodopsin. To re-use retinal, the all-trans-retinal form needs to be re-isomerized ... -
Ring Finger 149-Related Is an FGF/MAPK-Independent Regulator of Pharyngeal Muscle Fate Specification
(Journal article; Peer reviewed, 2023-05-16)During embryonic development, cell-fate specification gives rise to dedicated lineages that underlie tissue formation. In olfactores, which comprise tunicates and vertebrates, the cardiopharyngeal field is formed by ... -
A safer, urea-based in situ hybridization method improves detection of gene expression in diverse animal species
(Journal article, 2017)In situ hybridization is a widely employed technique allowing spatial visualization of gene expression in fixed specimens. It has proven to be essential to our understanding of biological processes, including developmental ... -
Some like it hot: population-specific adaptations in venom production to abiotic stressors in a widely distributed cnidarian
(Journal article; Peer reviewed, 2020-09)Background: In cnidarians, antagonistic interactions with predators and prey are mediated by their venom, whose synthesis may be metabolically expensive. The potentially high cost of venom production has been hypothesized ... -
The study of Priapulus caudatus reveals conserved molecular patterning underlying different gut morphogenesis in the Ecdysozoa
(Journal article; Peer reviewed, 2015-04-21)Background The digestive systems of animals can become highly specialized in response to their exploration and occupation of new ecological niches. Although studies on different animals have revealed commonalities in gut ... -
Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells
(Journal article; Peer reviewed, 2021)Physiological and pathological morphogenetic events involve a wide array of collective movements, suggesting that multicellular arrangements confer biochemical and biomechanical properties contributing to tissue-scale ... -
Syncytial nerve net in a ctenophore adds insights on the evolution of nervous systems
(Journal article; Peer reviewed, 2023)A fundamental breakthrough in neurobiology has been the formulation of the neuron doctrine by Santiago Ramón y Cajal, which stated that the nervous system is composed of discrete cells. Electron microscopy later confirmed ... -
Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes
(Journal article; Peer reviewed, 2009-08-21)Genomic regulatory blocks are chromosomal regions spanned by long clusters of highly conserved noncoding elements devoted to long-range regulation of developmental genes, often immobilizing other, unrelated genes into ...