Browsing Department of Clinical Science by Title

Now showing items 1309-1328 of 2347

    • Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders 

      Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn; Hjell, Gabriela; Ormerod, Monica; Haram, Marit; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Aukrust, Pål; Ueland, Thor; Andreassen, Ole; Steen, Nils Eiel (Journal article; Peer reviewed, 2022)
      Background Low-grade inflammation may be part of the underlying mechanism of schizophrenia and bipolar disorder. We investigated if genetic susceptibility, infections or autoimmunity could explain the immune activation. ...

    • Limited Benefit of Fish Consumption on Risk of Hip Fracture among Men in the Community-Based Hordaland Health Study 

      Rosendahl-Riise, Hanne; Sulo, Gerhard; Karlsson, Therese; Drevon, Christian A.; Dierkes, Jutta; Tell, Grethe S. (Peer reviewed; Journal article, 2018-07-06)
      Hip fractures have a high prevalence worldwide. Few studies have investigated whether fish consumption is associated with risk of hip fractures. The objective of the present study was to investigate the effect of fish ...

    • Limited clinical efficacy of azacitidine in transfusion-dependent, growth factor-resistant, low- and Int-1-risk MDS: Results from the nordic NMDSG08A phase II trial 

      Tobiasson, Magnus; Dybedal, Ingunn; Holm, Mette Skov; Karimi, Mohsen; Brandefors, Lena; Garelius, Hege; Grövdal, Michael; Høgh-Dufva, Inge; Grønbæk, Kirsten; Jansson, Monika; Marcher, Vlaus Werenberg; Nilsson, Lars Håkan; Kittang, Astrid Marta Olsnes; Porwit, Anna; Saft, Leonie; Möllgård, Lars; Hellström-Lindberg, Eva (Peer reviewed; Journal article, 2014)
      This prospective phase II study evaluated the efficacy of azacitidine (Aza)+erythropoietin (Epo) in transfusion-dependent patients with lower-risk myelodysplastic syndrome (MDS). Patients ineligible for or refractory to ...

    • Limited cross-border infections in patients newly diagnosed with HIV in Europe 

      Frentz, Dineke; Wensing, Annemarie M. J.; Albert, Jan; Paraskevis, Dimitrios; Abecasis, Ana B.; Hamouda, Osamah; Jørgensen, Louise B.; Kücherer, Claudia; Struck, Daniel; Schmit, Jean-Claude; Åsjø, Birgitta; Balotta, Claudia; Beshkov, Danail; Camacho, Ricardo J.; Clotet, Bonaventura; Coughlan, Suzie; De Wit, Stéphane; Griskevicius, Algirdas; Grossman, Zehava; Horban, Andrzej; Kolupajeva, Tatjana; Korn, Klaus; Kostrikis, Leondios G.; Liitsola, Kirsi; Linka, Marek; Nielsen, Claus; Otelea, Dan; Paredes, Roger; Poljak, Mario; Puchhammer-Stöckl, Elisabeth; Sönnerborg, Anders; Stanekova, Danica; Stanojevic, Maja; Vandamme, Anne-Mieke; Boucher, Charles A. B.; Van de Vijver, David A. M. C.; SPREAD Programme (Peer reviewed; Journal article, 2013-04-03)
      Background: International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous infections ...

    • Limited Genetic Overlap Between Overt Hashimoto's Thyroiditis and Graves' Disease in Twins: A Population-based Study 

      Skov, Jakob; Calissendorff, Jan; Eriksson, Daniel; Magnusson, Patrik K.; Kämpe, Olle; Bensing, Sophie; Kuja-Halkola, Ralf (Journal article; Peer reviewed, 2021)
      Context Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are known to coaggregate in families, but the magnitude and nature of a shared etiology is unknown. Objectives To estimate the shared genetic influence on ...

    • The link between wound healing and escape from tumor dormancy 

      Dillekås, Hanna; Straume, Oddbjørn (Peer reviewed; Journal article, 2019)
      Tumor dormancy is considered one of the major unsolved questions in cancer biology. Understanding the mechanisms responsible for maintaining and interrupting dormancy would be a major step towards preventing overt metastatic ...

    • Lipid effects during antipsychotic drug treatment and their relevance for clinical outcomes 

      Gjerde, Priyanthi Borgen (Doctoral thesis, 2020-01-29)
      Schizophrenia is a devastating mental disorder with disease mechanisms that are still poorly understood. Evidence has emerged that lipid dysregulations and myelination abnormalities might contribute to the pathophysiology ...

    • Lipid parameters and vitamin A modify cardiovascular risk prediction by plasma neopterin 

      Dhar, Indu; Siddique, Sumia; Pedersen, Eva Kristine Ringdal; Svingen, Gard FT; Lysne, Vegard; Olsen, Thomas; Nilsen, Dennis W.T.; Nordrehaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; Tell, Grethe S; Nygård, Ottar (Journal article; Peer reviewed, 2020)
      Objectives Oxidised cholesterol metabolites are linked to increased production of the active vitamin A (Vit-A) form and monocyte/macrophage activation, which may be reflected by neopterin, a marker of both interferon-γ–mediated ...

    • Liposomal formulation of an emetine analog in combination with daunorubicin for the treatment of acute myeloid leukemia 

      Bakke, Tuva Torblå (Master thesis, 2019-07-02)

    • A liposomal formulation of simvastatin and doxorubicin for improved cardioprotective and anti-cancer effect 

      Bjørnstad, Ronja; Reiten, Ingeborg Nerbø; Knudsen, Kaja Skålnes; Schjøtt, Jan Didrik; Herfindal, Lars (Journal article; Peer reviewed, 2022)
      Anthracyclines such as doxorubicin (Dox) are the preferred chemotherapeutics for several cancers. However, Dox-induced cardiotoxicity limits its therapeutic potential. Liposomal encapsulation of Dox has been used for ...

    • Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System 

      Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten; Grønberg, Bjørn Henning; Kalland, Karl Henning; Kopperud, Reidun Kristin; Thomsen, Liv Cecilie Vestrheim; Tjensvoll, Kjersti; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Hovland, Randi (Journal article; Peer reviewed, 2021)
      Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ...

    • Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma 

      Lapitz, Ainhoa; Azkargorta, Mikel; Milkiewicz, Piotr; Olaizola, Paula; Zhuravleva, Ekaterina; Grimsrud, Marit Mæhle; Schramm, Christoph; Arbelaiz, Ander; O'Rourke, Colm J.; La Casta, Adelaida; Milkiewicz, Malgorzata; Pastor, Tania; Vesterhus, Mette Nåmdal; Jimenez-Agüero, Raul; Dill, Michael T.; Lamarca, Angela; Valle, Juan W.; Macias, Rocio I.R.; Izquierdo-Sanchez, Laura; Pérez Castaño, Ylenia; Caballero-Camino, Francisco Javier; Riaño, Ioana; Krawczyk, Marcin; Ibarra, Cesar; Bustamante, Javier; Nova-Camacho, Luiz M.; Falcon-Perez, Juan M.; Elortza, Felix; Perugorria, Maria J.; Andersen, Jesper B.; Bujanda, Luis; Karlsen, Tom Hemming; Folseraas, Trine; Rodrigues, Pedro M.; Banales, Jesus M. (Journal article; Peer reviewed, 2023)
      Background & Aims Cholangiocarcinoma (CCA), heterogeneous biliary tumours with dismal prognosis, lacks accurate early diagnostic methods especially important for individuals at high-risk (i.e. those with primary sclerosing ...

    • Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders 

      Osete, Jordi Requena; Akkouh, Ibrahim; Reis de Assis, Denis; Szabo, Attila; Frei, Evgeniia; Hughes, Timothy; Smeland, Olav Bjerkehagen; Steen, Nils Eiel; Andreassen, Ole Andreas; Djurovic, Srdjan (Journal article; Peer reviewed, 2021)
      Lithium (Li), valproate (VPA) and lamotrigine (LTG) are commonly used to treat bipolar disorder (BD). While their clinical efficacy is well established, the mechanisms of action at the molecular level are still incompletely ...

    • Live Attenuated Influenza Vaccine (LAIV) Immunization in Children and Adults: Lesson for Development of Universal Influenza Vaccine 

      Islam, Shahinul (Doctoral thesis, 2019-11-06)
      According to the WHO (World Health Organization), one billion peoples are infected annually of whom three to five millions become severely ill and 250-500 000 deaths worldwide (He, Wang et al. 2013) although the latest ...

    • Live attenuated influenza vaccine in children induces b-cell responses in tonsils 

      Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Pathirana, Rishi; Bredholt, Geir; Jul-Larsen, Åsne; Trieu, Mai Chi; Jalloh, Sarah Larteley Lartey; Montemoli, Emanuele; Tøndel, Camilla; Aarstad, Hans Jørgen; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016)
      Background. Tonsils play a key role in eliciting immune responses against respiratory pathogens. Little is known about how tonsils contribute to the local immune response after intranasal vaccination. Here, we uniquely ...

    • Live-attenuated influenza vaccine induces tonsillar follicular T helper cell responses that correlate with antibody induction 

      Jalloh, Sarah Larteley Lartey; Zhou, Fan; Brokstad, Karl Albert; Mohn, Kristin Greve-Isdahl; Slettevoll, Steffen Aleksander; Pathirana, Rishi; Cox, Rebecca Jane (Journal article; Peer reviewed, 2020)
      Background: Influenza remains a major threat to public health. Live-attenuated influenza vaccines (LAIV) have been shown to be effective, particularly in children. Follicular T helper (TFH) cells provide B-cell help and ...

    • Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes 

      Jain, Ruchi; Özgümüs, Türküler; Jensen, Troels Mygind; du Plessis, Elsa; Keindl, Magdalena; Møller, Cathrine Laustrup; Falhammar, Henrik; Nyström, Thomas; Catrina, Sergiu-Bogdan; Jörneskog, Gun; Jessen, Leon Eyrich; Forsblom, Carol; Haukka, Jani K.; Groop, Per-Henrik; Rossing, Peter; Groop, Leif; Eliasson, Mats; Eliasson, Björn; Brismar, Kerstin; Al-Majdoub, Mahmoud; Nilsson, Peter M.; Taskinen, Marja-Riitta; Ferrannini, Ele; Spégel, Peter; Berg, Tore Julsrud; Lyssenko, Valeriya (Journal article; Peer reviewed, 2020)
      Identification of biomarkers associated with protection from developing diabetic complications is a prerequisite for an effective prevention and treatment. The aim of the present study was to identify clinical and plasma ...

    • The liver-heart axis in patients with severe obesity: the association between liver fibrosis and chronic myocardial injury may be explained by shared risk factors of cardiovascular disease 

      Young, Juliet; Seeberg, Kathrine; Aakre, Kristin Moberg; Borgeraas, Heidi; Nordstrand, Njord; Wisløff, Torbjørn; Hjelmesæth, Jøran Sture; Omland, Torbjørn; Hertel, Jens Kristoffer (Journal article; Peer reviewed, 2024)
      Background: Severe obesity is associated with increased risk of non-alcoholic fatty liver disease and cardiovascular disease. We hypothesized that liver fibrosis as quantified by the Enhanced Liver Fibrosis (ELF) test would ...

    • Living With Ovarian Cancer: Transitions Lost in Translation 

      Gissum, Karen Rosnes; Drageset, Sigrunn; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Strand, Roger (Journal article, 2022)
      Background: Living with ovarian cancer involves uncertainty, fear of recurrence, and premature death while preparing for a life after treatment. The women depend on health care professionals while moving from being healthy ...

    • LOC689986, a unique gene showing specific expression in restricted areas of the rodent neocortex 

      Ersland, Kari Merete; Håvik, Bjarte; Rinholm, Johanne Egge; Gundersen, Vidar; Stansberg, Christine; Steen, Vidar Martin (Peer reviewed; Journal article, 2013-07-11)
      Background: The neocortex is a highly specialised and complex brain structure, involved in numerous tasks, ranging from processing and interpretation of somatosensory information, to control of motor functions. The normal ...