Browsing Department of Clinical Science by Title
Now showing items 1711-1730 of 2348
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Plasma-Metanephrines in Patients with Autoimmune Addison’s Disease with and without Residual Adrenocortical Function
(Journal article; Peer reviewed, 2023-05-22)Purpose: Residual adrenocortical function, RAF, has recently been demonstrated in one-third of patients with autoimmune Addison’s disease (AAD). Here, we set out to explore any influence of RAF on the levels of plasma ... -
Platelet functionality in cold-stored whole blood
(Peer reviewed; Journal article, 2019)Whole blood is currently being reintroduced as a blood product to be used in massive bleeding situations because it affords plasma, red cells and platelets in a balanced ratio and in a logistical advantageous way. Questions ... -
Platelet microparticles decrease daunorubicin‐induced dna damage and modulate intrinsic apoptosis in thp‐1 cells
(Journal article; Peer reviewed, 2021)Platelets can modulate cancer through budding of platelet microparticles (PMPs) that can transfer a plethora of bioactive molecules to cancer cells upon internalization. In acute myelogenous leukemia (AML) this can induce ... -
Platelet Microparticles Protect Acute Myelogenous Leukemia Cells against Daunorubicin-Induced Apoptosis
(Journal article; Peer reviewed, 2021)The role of platelets in cancer development and progression is increasingly evident, and several platelet–cancer interactions have been discovered, including the uptake of platelet microparticles (PMPs) by cancer cells. ... -
Platelets for advanced drug delivery in cancer
(Journal article; Peer reviewed, 2023)Introduction: Cancer-related drug expenses are rising with the increasing cancer incidence and cost may represent a severe challenge for drug access for patients with cancer. Consequently, strategies for increasing therapeutic ... -
Pleckstrin Levels Are Increased in Patients with Chronic Periodontitis and Regulated via the MAP Kinase-p38α Signaling Pathway in Gingival Fibroblasts
(Journal article; Peer reviewed, 2022)Chronic periodontitis (CP) is a bacteria-driven inflammatory disease characterized by the breakdown of gingival tissue, the periodontal ligament, and alveolar bone, leading ultimately to tooth loss. We previously reported ... -
Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections
(Journal article; Peer reviewed, 2023)Background Many community-acquired pleural infections are caused by facultative and anaerobic bacteria from the human oral microbiota. The epidemiology, clinical characteristics, pathogenesis, and etiology of such ... -
PNPLA 3 I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection
(Peer reviewed; Journal article, 2012-09-14)Background: Hepatic steatosis in HCV patients has been postulated as a risk factor associated with a higher frequency of fibrosis and cirrhosis. A single genetic variant, PNPLA3 I148M, has been widely associated with ... -
Point Shear Wave Elastography and the Effect of Physical Exercise, Alcohol Consumption, and Respiration in Healthy Adults
(Journal article; Peer reviewed, 2020)Purpose Ultrasound elastography is a noninvasive method for liver stiffness measurement (LSM) with the aim of reflecting approximate liver fibrosis load. Despite minimal evidence, current guidelines recommend 10 min of ... -
Point-of-care high-sensitivity troponin assays: Advancements, clinical applications, and implementation considerations
(Journal article; Peer reviewed, 2023)High-sensitivity cardiac troponin (hs-cTn) assays have changed the workflow in emergency departments allowing for rapid allocation of patients with high or low risk of non-ST elevation myocardial infarction. Recently, ... -
Point-of-care influenza testing impacts clinical decision, patient flow and length of stay in hospitalized adults
(Journal article; Peer reviewed, 2022)Background Influenza is difficult to distinguish clinically from other acute respiratory infections. Rapid laboratory diagnosis can help initiate early effective antiviral treatment and isolation. Implementing a novel ... -
Polarizing versus depolarizing blood cardioplegia: An experimental study of myocardial function, metabolism and ultrastructure following cardiopulmonary bypass and cardioplegic arrest
(Doctoral thesis, 2019-01-11)In cardiothoracic surgery, the use of the heart-lung machine for cardiopulmonary bypass (CPB) and induced cardiac arrest, cardioplegia, is required for performing the majority of the surgical procedures. Myocardial protection ... -
Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease
(Peer reviewed; Journal article, 2015-06)Background—Epidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood. We investigated whether this ... -
Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia
(Journal article; Peer reviewed, 2023)Treatment resistant schizophrenia (TRS) is characterized by repeated treatment failure with antipsychotics. A recent genome-wide association study (GWAS) of TRS showed a polygenic architecture, but no significant loci were ... -
Polygenic risk modeling for prediction of epithelial ovarian cancer risk
(Journal article; Peer reviewed, 2022)Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance ... -
A polygenic risk score to help discriminate primary adrenal insufficiency of different etiologies
(Journal article; Peer reviewed, 2023)Background Autoimmune Addison's disease (AAD) is the most common cause of primary adrenal insufficiency (PAI). Despite its exceptionally high heritability, tools to estimate disease susceptibility in individual patients ... -
Polygenic scores for schizophrenia and general cognitive ability: associations with six cognitive domains, premorbid intelligence, and cognitive composite score in individuals with a psychotic disorder and in healthy controls
(Journal article; Peer reviewed, 2020-11)Cognitive impairments are considered core features in schizophrenia and other psychotic disorders. Cognitive impairments are, to a lesser degree, also documented in healthy first-degree relatives. Although recent studies ... -
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males
(Journal article; Peer reviewed, 2021)The polymorphism L412F in TLR3 has been associated with several infectious diseases. However, the mechanism underlying this association is still unexplored. Here, we show that the L412F polymorphism in TLR3 is a marker of ... -
Polymorphisms in the TP53-MDM2-MDM4-axis in patients with rheumatoid arthritis
(Journal article; Peer reviewed, 2021)Background In addition to being a tumour suppressor, TP53 is a suppressor of inflammation, and dysfunction of this gene has been related to autoimmune diseases. Patients with autoimmunity, such as rheumatoid arthritis ... -
Poor outcome in hypoxic endometrial carcinoma is related to vascular density
(Peer reviewed; Journal article, 2019-04-23)Background Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. Methods Tumour slides ...