Browsing Department of Clinical Science by Title
Now showing items 1731-1750 of 2348
-
A population based validation study of self-reported pensions and benefits: the Nord-Trøndelag health study (HUNT)
(Peer reviewed; Journal article, 2013-01-23)Background: Measures of disability pensions, sickness certification and long-term health related benefits are often self-reported in epidemiological studies. Few studies have examined these measures, and the validity is ... -
Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)
(Peer reviewed; Journal article, 2014-04-18)The MDM2 promoter SNP285C is located on the SNP309G allele. While SNP309G enhances Sp1 transcription factor binding and MDM2 transcription, SNP285C antagonizes Sp1 binding and reduces the risk of breast-, ovary- and ... -
Population pharmacokinetics of tacrolimus in kidney transplant recipients - A model for individual dosing
(Master thesis, 2012-11-01)Background: Population pharmacokinetics is the study of pharmacokinetic variability in the population. One goal of such studies is to improve individual drug treatment by identifying relationships between pharmacokinetic ... -
Population prevalence and inheritance pattern of recurrent CNVs associated with neurodevelopmental disorders in 12,252 newborns and their parents
(Journal article; Peer reviewed, 2020)Recurrent copy number variations (CNVs) are common causes of neurodevelopmental disorders (NDDs) and associated with a range of psychiatric traits. These CNVs occur at defined genomic regions that are particularly prone ... -
A positive association between nutritional risk and the incidence of surgical site infections: A hospital-based register study
(Peer reviewed; Journal article, 2018-05-15)Surgical site infections (SSI) are amongst the most common health care-associated infections and have adverse effects for patient health and for hospital resources. Although surgery guidelines recognize poor nutritional ... -
The possible importance of β3 integrins for leukemogenesis and chemoresistance in acute myeloid leukemia
(Peer reviewed; Journal article, 2018-01-15)Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy where the immature leukemia cells communicate with neighboring cells through constitutive cytokine release and through their cell surface adhesion ... -
Possible interactions between EGFR vIII mediated regulation of proliferation and metabolism in glioma cells
(Master thesis, 2009-05-20)The life cycle of a normal cell is strictly controlled by multiple check points and regulatory factors. Cancer cells on the other hand contain defects in the regulatory machinery that govern cell proliferation and homeostasis, ... -
Post COVID-19 condition after delta infection and omicron reinfection in children and adolescents
(Journal article; Peer reviewed, 2023)Background: The burden of COVID-19 in children and adolescents has increased during the delta and omicron waves, necessitating studies of long-term symptoms such as fatigue, dyspnoea and cognitive problems. Furthermore, ... -
Postpartum hemorrhage in families : A Norwegian population-based study
(Doctoral thesis, 2022-10-27)Bakgrunn: Postpartum blødning (PPB) er den ledende direkte årsaken til verdens mødredødelighet og forekomsten har en økende trend i utviklende land. Mål: Å studere gjentagelsesrisiko for PPB hos en kvinne, over generasjoner ... -
A Potential Golden Age to Come-Current Tools, Recent Use Cases, and Future Avenues for De Novo Sequencing in Proteomics
(Peer reviewed; Journal article, 2018-07-02)In shotgun proteomics, peptide and protein identification is most commonly conducted using database search engines, the method of choice when reference protein sequences are available. Despite its widespread use the ... -
Potential Transcriptional Biomarkers to Guide Glucocorticoid Replacement in Autoimmune Addison's Disease
(Journal article; Peer reviewed, 2021)Background No reliable biomarkers exist to guide glucocorticoid (GC) replacement treatment in autoimmune Addison’s disease (AAD), leading to overtreatment with alarming and persistent side effects or undertreatment, which ... -
The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL
(Journal article; Peer reviewed, 2020)Tetradecylthioacetic acid (TTA) is a synthetic fatty acid with a sulfur substitution in the β-position. This modification renders TTA unable to undergo complete β-oxidation and increases its biological activity, including ... -
Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells
(Peer reviewed; Journal article, 2007)Background: Acute myeloid leukemia (AML) cells are characterized by non-mutated TP53, high levels of Hdm2, and frequent mutation of the Flt3 receptor tyrosine kinase. The juxtamembrane mutation of FLT3 is the strongest ... -
Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies
(Journal article; Peer reviewed, 2021)Few prospective studies have evaluated the relation between fat-soluble vitamins and glioma risk. Using three cohorts—UK Biobank (UKB), Nurses’ Health Study (NHS), and Health Professionals Follow-Up Study (HPFS), we ... -
Pre-gestational diabetes: Maternal body mass index and gestational weight gain are associated with augmented umbilical venous flow, fetal liver perfusion, and thus birthweight
(Journal article; Peer reviewed, 2021)Objectives To assess how maternal body mass index and gestational weight gain are related to on fetal venous liver flow and birthweight in pregnancies with pre-gestational diabetes mellitus. Methods In a longitudinal ... -
Preclinical cardiac disease in women and men with primary aldosteronism
(Journal article; Peer reviewed, 2021)Purpose: We tested the sex-specific associations between primary aldosteronism (PA), left ventricular (LV) hypertrophy and LV systolic myocardial function. Material and methods: Conventional and speckle tracking ... -
Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma
(Peer reviewed; Journal article, 2019-02-21)Background: FGFR inhibition has been proposed as treatment for dedifferentiated liposarcoma (DDLPS) with amplified FRS2, but we previously only demonstrated transient cytostatic effects when treating FRS2-amplified DDLPS ... -
Preclinical models and molecular biomarkers. Tools to improve treatment in endometrial carcinoma
(Doctoral thesis, 2018-11-30)Background: Endometrial carcinoma is the fourth most common cancer in European women, and incidence is increasing. No major improvements in treatment or survival have been achieved over the last decades, and an individualized ... -
Preclinical molecular imaging in oncology – From chemical synthesis to clinical translatable applications
(Doctoral thesis, 2021-06-25)Background: Molecular imaging (MI) is fundamental in clinical settings for diagnosis, treatment selection, intraoperative guidance and treatment efficacy evaluation. This field has progressed rapidly in recent years, driven ...