Browsing Department of Clinical Science by Title
Now showing items 557-576 of 2348
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Diets differing in carbohydrate cellularity and amount similarly reduced visceral fat in people with obesity - a randomized controlled trial (CARBFUNC)
(Journal article; Peer reviewed, 2022)Background & aims: Visceral adipose tissue (VAT) volume is associated with common lifestyle diseases. Dietary quality, including food matrix and degree of carbohydrate cellularity, as well as the carbohydrate/fat ratio, ... -
Differences in lung function, bronchial hyperresponsiveness and respiratory health between elite athletes competing in different sports
(Journal article; Peer reviewed, 2022)The aim of this study was to examine lung function, bronchial hyperresponsiveness (BHR) and exercise-induced respiratory symptoms in elite athletes performing different sports. Norwegian national-team athletes (30 swimmers, ... -
Differences in metastatic patterns in relation to time between primary surgery and first relapse from breast cancer suggest synchronized growth of dormant micrometastases
(Peer reviewed; Journal article, 2014-08)A significant variation in the metastatic pattern among breast cancer patients exists. Clinical observations suggest that these differences are related to time to recurrence (TTR), thus suggesting a common systemic growth ... -
Differences in white blood cell proportions between schizophrenia cases and controls are influenced by medication and variations in time of day
(Journal article; Peer reviewed, 2023)Cases with schizophrenia (SCZ) and healthy controls show differences in white blood cell (WBC) counts and blood inflammation markers. Here, we investigate whether time of blood draw and treatment with psychiatric medications ... -
Different adipose tissue development in mice pair fed fish oil and different carbohydrates
(Master thesis, 2011-05-16)Obesity causes several health problems, including insulin resistance, Type 2 diabetes, heart diseases, disrupted energy metabolism and low-grade inflammation. Being obese increases the risk of getting metabolic syndrome. ... -
Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)alpha agonist fenofibrate and the PPAR gamma agonist pioglitazone
(Peer reviewed; Journal article, 2009-03-30)Background: All the peroxisome proliferator activated receptors (PPARs) are found to be expressed in bone cells. The PPARγ agonist rosiglitazone has been shown to decrease bone mass in mice and thiazolidinediones (TZDs) ... -
Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation
(Journal article; Peer reviewed, 2020)Background Myeloid-derived suppressor cells (MDSC) are a functional myeloid cell subset that includes myeloid cells with immune suppressive properties. The presence of MDSC has been reported in the peripheral blood of ... -
Differential sensitivity of the 2020 revised comprehensive diagnostic criteria and the 2019 ACR/EULAR classification criteria across IgG4-related disease phenotypes: results from a Norwegian cohort
(Journal article; Peer reviewed, 2023)Background We investigated sensitivity of the 2020 Revised Comprehensive Diagnostic Criteria (RCD) and the 2019 ACR/EULAR classification criteria across the four identified IgG4-related disease (IgG4-RD) phenotypes: ... -
Diffusing capacity of the lung for carbon monoxide. Variability and longitudinal changes over nine years
(Doctoral thesis, 2019-03-13)Pulmonary gas exchange oxygenates our blood and facilitates transfer of carbon dioxide produced out of the body. Measurement of pulmonary gas exchange by diffusing capacity of the lung for carbon monoxide (DLCO) shows a ... -
Diffusion tension imaging is a good tool for assessing patients with dementia and behavioral problems and discriminating them from other dementia patients
(Journal article; Peer reviewed, 2021)Background Dementia is one of the leading public health concerns as the world’s population ages. Although Alzheimer’s disease (AD) is the most common dementia diagnosis among older patients, some patients have additional ... -
Diflubenzuron in Atlantic Cod (Gadus morhua) - Multiple Dose Pharmacokinetic Study
(Master thesis, 2012-05-21)Diflubenzuron, a chitin synthesis inhibitor, is used as a parasiticide against sea lice in farmed salmonids. It is administered orally via medicated feed pellets. Due to low bioavailability and biliary secretion of the ... -
Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin–angiotensin–aldosterone system in patients with heart failure
(Journal article; Peer reviewed, 2021)Aims Recently, dipeptidyl peptidase 3 (DPP3) has been discovered as the peptidase responsible for cleavage of angiotensin (1–7) [Ang (1–7)]. Ang (1–7) is part of the angiotensin-converting enzyme–Ang (1–7)–Mas pathway ... -
Discharge care quality in hospitalised elderly patients: Extended validation of the Discharge Care Experiences Survey
(Peer reviewed; Journal article, 2019)Background: The Discharge Care Experiences Survey (DICARES) was previously developed to measure quality of discharge care in elderly patients (≥ 65 years). The objective of this study was to test the factorial validity of ... -
Discovery and characterization of novel STAT3 and androgen receptor inhibitors in prostate cancer cells
(Doctoral thesis, 2020-05-04)Prostate cancer (PCa) recurs and leads to incurable castration-resistant prostate cancer (CRPC) after the failure of androgen deprivation therapies (ADT). CRPC development relies on androgen receptor (AR) signalling. The ... -
Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy
(Peer reviewed; Journal article, 2015)Owing to their integral involvement in cell cycle regulation, the Polo-like kinase (Plk) family, particularly Plk1, has emerged as an attractive therapeutic target in oncology. In recent years, several Plk1 inhibitors have ... -
Discovery of novel candidates for anti- liposarcoma therapies by medium-scale high-throughput drug screening
(Journal article; Peer reviewed, 2021)Sarcomas are a heterogeneous group of mesenchymal orphan cancers and new treatment alternatives beyond traditional chemotherapeutic regimes are much needed. So far, tumor mutation analysis has not led to significant treatment ... -
Discovery of novel potential reversible peptidyl arginine deiminase inhibitor
(Peer reviewed; Journal article, 2019)Citrullination, a posttranslational modification, is catalyzed by peptidylarginine deiminases (PADs), a unique family of enzymes that converts peptidyl-arginine to peptidyl-citrulline. Overexpression and/or increased PAD ... -
Discovery of shared genomic loci using the conditional false discovery rate approach
(Peer reviewed; Journal article, 2020)In recent years, genome-wide association study (GWAS) sample sizes have become larger, the statistical power has improved and thousands of trait-associated variants have been uncovered, offering new insights into the genetic ... -
Dissecting the hemagglutinin head and stalk-specific IgG antibody response in healthcare workers following pandemic H1N1 vaccination
(Peer reviewed; Journal article, 2016-07-28)Traditionally, neutralising antibodies that are directed to the major surface glycoprotein hemagglutinin (HA) head domain are measured as surrogate correlates of protection against influenza. In addition to neutralization, ... -
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
(Journal article; Peer reviewed, 2022)Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic ...