Blar i Department of Clinical Science på tittel
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The systemic metabolic profile early after allogeneic stem cell transplantation: Effects of adequate energy support administered through enteral feeding tube
(Journal article; Peer reviewed, 2020)Patients undergoing allogeneic stem cell transplantation usually require nutritional support. There is no consensus on whether enteral support through tube feeding should be preferred. A recent randomized study could not ... -
Systemic metabolomic profiles in adult patients with bacterial sepsis: Characterization of patient heterogeneity at the time of diagnosis
(Journal article; Peer reviewed, 2023-01-24)Sepsis is a dysregulated host response to infection that causes potentially life-threatening organ dysfunction. We investigated the serum metabolomic profile at hospital admission for patients with bacterial sepsis. The ... -
Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy
(Peer reviewed; Journal article, 2019-10-10)Acute myeloid leukemia (AML) is an aggressive malignancy, and many elderly/unfit patients cannot receive intensive and potentially curative therapy. These patients receive low-toxicity disease-stabilizing treatment. The ... -
Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure
(Journal article; Peer reviewed, 2023)Background: Oxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum-free thiol concentrations, as a marker of systemic oxidative stress, in HF ... -
The systemic profile of soluble immune mediators in patients with myelodysplastic syndromes
(Peer reviewed; Journal article, 2016-07-05)Introduction: Myelodysplastic syndromes (MDS) are characterized by bone marrow failure due to disturbed bone marrow maturation. MDS is associated with increased risk of transformation to acute myeloid leukemia (AML) and ... -
Systolic myocardial function measured by echocardiographic speckle-tracking and peak oxygen consumption in pediatric childhood cancer survivors—a PACCS study
(Journal article; Peer reviewed, 2023)Background: Cancer therapy-related cardiotoxicity is a major cause of cardiovascular morbidity in childhood cancer survivors. The aims of this study were to investigate systolic myocardial function and its association to ... -
T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ
(Peer reviewed; Journal article, 2017-07)Next generation sequencing of T and B cell receptors is emerging as a valuable and effective method to diagnose and monitor hematopoietic malignancies. So far, this approach has not been fully explored in regard to autoimmune ... -
T Cell Responses and Regulation and the Impact of In Vitro IL-10 and TGF-beta Modulation During Treatment of Active Tuberculosis
(Peer reviewed; Journal article, 2017-02)Mycobacterium tuberculosis (Mtb) is particularly challenging for the immune system being an intracellular pathogen, and a variety of T cell subpopulations are activated by the host defence mechanism. In this study, we ... -
Tablettknusing i eldreomsorgen, sett fra et legemiddelteknologisk perspektiv
(Master thesis, 2011-05-19)Bakgrunn: Vi blir stadig eldre og med økende alder følger også økt morbiditet og dermed også medisinbruk. Mange eldre bor i omsorgsboliger og får tildelt medisiner av helsepersonell. Ofte kan det av ulike grunner være behov ... -
Tailoring NIV by dynamic laryngoscopy in a child with spinal muscular atrophy type I
(Journal article; Peer reviewed, 2021)Dynamic laryngoscopy during noninvasive (NIV) respiratory therapy is feasible and may facilitate optimal and individualized treatment in patients with chronic respiratory failure, also in children. -
TAKROLIMUS -Farmakokinetikk i tidlig fase etter levertransplantasjon
(Master thesis, 2009-05-20)Takrolimus er del av standard immunsuppresjon og vedlikeholdsdoseringsregimet etter levertransplantasjon. Det har et smalt terapeutisk vindu, og monitorers derfor etter bunnkonsentrasjonsmålinger. Intra- og interindividuelle ... -
TAM-reseptoruttrykk i labiale spyttkjertler hos pasienter med primært Sjögrens syndrom
(Master thesis, 2023-05-22)Hensikt: Studien sammenlignet TAM-reseptoruttrykk i labiale spyttkjertler mellom pasienter med primært Sjögrens syndrom og kontroller med sicca symptomer for å identifisere potensiell svekkelse av apoptotisk cellefjerning ... -
Tamoxifen in the treatment of luminal breast cancer. Implications of active metabolites on gene expression, side effects and clinical outcome
(Doctoral thesis, 2019-02-21)Estrogen is a driver for the development and progression of luminal breast cancer, and up to 80% of all breast cancers diagnosed belong to the luminal subtype. The estrogenic effect on breast tumors can be reduced by the ... -
Teaching geriatric medicine through gamification: a tool for enhancing postgraduate education in geriatric medicine
(Journal article; Peer reviewed, 2022)Background Polypharmacy is becoming increasingly common and all doctors must be prepared to manage it competently. Aims The aim of this project is to evaluate the feasibility and use of a novel gamification-based ... -
Temporal trends of β-haemolytic streptococcal osteoarticular infections in western Norway
(Peer reviewed; Journal article, 2016-10-04)Background: Beta-haemolytic streptococci are important contributors to the global burden of osteoarticular infections (OAI). Knowledge on the disease traits specific for streptococcal OAI, however, remains scarce. We wished ... -
Tentative longterm effects of a noradrenergic antidepressant; affecting the number of glucose transporters
(Master thesis, 2008-06-01)Major depressive disorder is an affective disorder affecting millions of people worldwide. Only in Europe at least 21 million are thought to be affected. Several theories have been developed during the years trying to ... -
Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty
(Peer reviewed; Journal article, 2020)Context: Testicular growth represents the best clinical variable to evaluate male puberty, but current pediatric hormone references are based on chronological age and subjective assessments of discrete puberty development ... -
Tetradecylthioacetic Acid Increases Hepatic Mitochondrial b-Oxidation and Alters Fatty Acid Composition in a Mouse Model of Chronic Inflammation
(Peer reviewed; Journal article, 2011-04-09)The administration of tetradecylthioacetic acid (TTA), a hypolipidemic and anti-inflammatory modified bioactive fatty acid, has in several experiments based on high fat diets been shown to improve lipid transport and ... -
Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells - gene expression profiling implies endoplasmic reticulum stress
(Peer reviewed; Journal article, 2011-10-25)Background: Previous reports have shown an antiproliferative effect of the synthetic, 3-thia fatty acid tetradecylthioacetic acid (TTA) on different cancer cells in vitro and in vivo. The mechanisms behind the observed ... -
Tetradecylthiopropionic acid induces hepatic mitochondrial dysfunction and steatosis, accompanied by increased plasma homocysteine in mice
(Peer reviewed; Journal article, 2016-02-05)Background: Hepatic mitochondrial dysfunction plays an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Methyl donor supplementation has been shown to alleviate NAFLD, connecting the condition ...