Browsing Department of Clinical Science by Title
Now showing items 1143-1162 of 2340
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Improving response to progestin treatment of low-grade endometrial cancer
(Journal article; Peer reviewed, 2020)Objectives This review examines how response rates to progestin treatment of low-grade endometrial cancer can be improved. In addition to providing a brief overview of the pathogenesis of low-grade endometrial cancer, ... -
Improving the procedural safety and efficacy of radiofrequency catheter ablation for atrial fibrillation. Studies with special focus on non-paroxysmal atrial fibrillation
(Doctoral thesis, 2015-01-30)Introduction: Atrial fibrillation (AF) is the most common sustained arrhythmia, and it is responsible for increased mortality and a reduced quality of life. Its prevalence is rapidly increasing. Catheter ablation has emerged ... -
Improving translational research in sex-specific effects of comorbidities and risk factors in ischaemic heart disease and cardioprotection: Position paper and recommendations of the ESC Working Group on Cellular Biology of the Heart
(Journal article; Peer reviewed, 2021)Ischaemic heart disease (IHD) is a complex disorder and a leading cause of death and morbidity in both men and women. Sex, however, affects several aspects of IHD, including pathophysiology, incidence, clinical presentation, ... -
Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy
(Journal article; Peer reviewed, 2023)Background Impulsivity is a transdiagnostic feature linked to severe clinical expression and a potential target for psychopharmacological strategies. Biological underpinnings are largely unknown, but involvement of ... -
In depth analyses of peripheral blood immune cell populations in patients with psoriasis - effect of biological treatment and alternative medicine
(Doctoral thesis, 2023-04-26)Psoriasis er en kronisk immun-mediert sykdom i huden med systemisk betennelse og ledsagende komorbiditeter. Selv om alvorlighetsgraden av sykdommen kan variere over tid, lider de fleste pasienter med psoriasis av mild til ... -
In silico analysis provides insights for patient-specific annuloplasty in Barlow’s disease
(Journal article; Peer reviewed, 2023)Objective To predict the required mitral annular area reduction in patients with Barlow's disease to obtain a predefined leaflet area index by a novel in silico modeling method. Methods Three-dimensional echocardiography ... -
In vitro analysis of antigen induced T cell-monocyte conjugates by imaging flow cytometry
(Peer reviewed; Journal article, 2018)There is a lack of suitable correlates of immune protection against Mycobacterium tuberculosis (Mtb) infection. T cells and monocytes play key roles in host immunity against Mtb. Thus, a method that allows assessing their ... -
In vitro characteristics and in vivo platelet quality of whole blood treated with riboflavin and UVA/UVB light and stored for 24 hours at room temperature
(Journal article; Peer reviewed, 2021)Background There is a global increase in whole blood usage and at the same time, emerging pathogens give cause for pathogen reduction technology (PRT). The Mirasol PRT has shown promising results for plasma and platelet ... -
In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins
(Peer reviewed; Journal article, 2017)Spinocerebellar ataxia, autosomal recessive 16 (SCAR16) is caused by biallelic mutations in the STIP1 homology and U-box containing protein 1 (STUB1) gene encoding the ubiquitin E3 ligase and dimeric co-chaperone C-terminus ... -
In Vitro Characterization of Valproic Acid, ATRA, and Cytarabine Used for Disease-Stabilization in Human Acute Myeloid Leukemia: Antiproliferative Effects of Drugs on Endothelial and Osteoblastic Cells and Altered Release of Angioregulatory Mediators by Endothelial Cells.
(Peer reviewed; Journal article, 2014-01-08)The combined use of the histone deacetylase inhibitor valproic acid (VPA), the retinoic acid receptor-α agonist all-trans retinoic acid (ATRA), and the deoxyribonucleic acid polymerase-α inhibitor cytarabine (Ara-C) is now ... -
In vitro cytotoksisk effekt av venom fra vestlig honningbie (Apis mellifera) hos glioblastoma cellelinjer av typen U251 og C6.
(Master thesis, 2008-06-01)Flere in vitro-metoder kan benyttes til å evaluere både generell og organspesifikk toksisitet. Disse metodene kan kombineres med bioprospektering for å screene mulige legemidler for cytotoksisk effekt, og samtidig begrense ... -
In vitro quality of cold and delayed cold-stored platelet concentrates from interim platelet units during storage for 21 days
(Journal article; Peer reviewed, 2023)Background and Objectives: Based on previous success using apheresis platelets, we wanted to investigate the in vitro quality and platelet function in continuously cold-stored and delayed cold-stored platelet concentrates ... -
In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome
(Peer reviewed; Journal article, 2013-09-09)Introduction: Therapeutic vaccination with antigen-specific tolerogenic dendritic cells (tolDC) might become a future option of individualized therapy for patients with autoimmune diseases. In this study, we tested the ... -
In vivo biodistribution of fluorescent nanocolloids intended for drug delivery - Evaluation of PEGylation state and fluorophore incorporation approach.
(Master thesis, 2012-05-31)To move the use of PLGA nanocolloids from laboratories towards the use in humans require careful investigations around pharmacokinetics and biodistributions. The biodistributions of the nanocolloids can be traced through ... -
In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism
(Journal article; Peer reviewed, 2020)Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy for improving or curing insulin-dependent diabetes. The transplantation of end-stages differentiating ... -
In vivo hyperglycemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress
(Peer reviewed; Journal article, 2020)Aim: The loss of insulin‐secreting β‐cells, ultimately characterizing most diabetes forms, demands the development of cell replacement therapies. The common endpoint for all ex vivo strategies is transplantation into ... -
Incidence and Prognostic Significance of the Segond Fracture in Patients Undergoing Anterior Cruciate Ligament Reconstruction
(Journal article; Peer reviewed, 2020)Background: The Segond fracture is an avulsion of the anterolateral tibia that can be found in patients with an anterior cruciate ligament (ACL) tear. It is currently unclear if the Segond fracture needs treatment or if ... -
Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT)
(Journal article; Peer reviewed, 2021)Introduction Bleeding is a concern after percutaneous coronary intervention (PCI) and subsequent dual antiplatelet therapy (DAPT). We herein report the incidence and risk factors for major bleeding in the Norwegian ... -
Incidence of newborn resuscitative interventions at birth and short-term outcomes: A regional population-based study
(Peer reviewed; Journal article, 2019)Objectives: To determine the incidence and characteristics of resuscitative interventions at different gestational ages and short-term outcomes after resuscitation. Design, setting and patients: A prospective observational ...