Blar i Department of Clinical Science på tittel
Viser treff 1465-1484 av 2426
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Metabolic Profiling in Maturity-Onset Diabetes of the Young (MODY) and Young Onset Type 2 Diabetes Fails to Detect Robust Urinary Biomarkers
(Peer reviewed; Journal article, 2012-07-30)It is important to identify patients with Maturity-onset diabetes of the young (MODY) as a molecular diagnosis determines both treatment and prognosis. Genetic testing is currently expensive and many patients are therefore ... -
Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease
(Journal article; Peer reviewed, 2023)Background: The valine (branched-chain amino acid) metabolite 3-hydroxyisobutyrate (3-HIB), produced by 3-Hydroxyisobutyryl-CoA Hydrolase (HIBCH), is associated with insulin resistance and type 2 diabetes, but implicated ... -
Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for patients with and without posttransplant capillary leak syndrome
(Peer reviewed; Journal article, 2015-12)Allogeneic stem cell transplantation is commonly used in the treatment of younger patients with severe hematological diseases, and endothelial cells seem to be important for the development of several posttransplant ... -
Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity
(Journal article; Peer reviewed, 2019)Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ... -
Metformin exposure, maternal PCOS status and fetal venous liver circulation: A randomized, placebo-controlled study
(Journal article; Peer reviewed, 2022-01-28)Background: Metformin is prescribed to women with polycystic ovary syndrome (PCOS) to prevent pregnancy complications. Children exposed to metformin vs. placebo in utero, have increased head circumference at birth and are ... -
Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2)
(Peer reviewed; Journal article, 2015-11-09)The ability of the anti-diabetic drug metformin to inhibit anabolic processes including gluconeogenesis and lipogenesis is partly attributable to activation of the AMP-activated protein kinase (AMPK) pathway. The p160 ... -
Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment
(Journal article; Peer reviewed, 2023)The gut microbiota play a crucial role in maintaining host health and have a significant impact on human health and disease. In this study, we investigated the alpha diversity of gut microbiota in COVID-19 patients and ... -
Methodological issues in airway microbiome studies
(Doctoral thesis, 2020-12-04)Background Studies on the lung microbiome face unique methodological challenges tied to the low bacterial load of acquired samples and the increased susceptibility to bacterial DNA contamination. Contamination may be ... -
Meticillinresistente gule stafylokokker i sårsekret hos barn
(Journal article; Peer reviewed, 2022)BAKGRUNN Hud- og bløtvevsinfeksjoner er vanlig hos barn. Vi ønsket å undersøke forekomsten av meticillinresistens blant gule stafylokokker i sårsekret fra barn i Norge. MATERIALE OG METODE Vi gjennomførte en ... -
Metric based virtual simulation training for endovascular thrombectomy improves interventional neuroradiologists’ simulator performance
(Journal article; Peer reviewed, 2022)Objective Metric based virtual reality simulation training may enhance the capability of interventional neuroradiologists (INR) to perform endovascular thrombectomy. As pilot for a national simulation study we examined ... -
Metronidazole-sensitive organisms in children with severe acute malnutrition: an evaluation of the indication for empiric metronidazole treatment
(Peer reviewed; Journal article, 2020)Objectives: Children with severe acute malnutrition (SAM) are treated with empiric amoxicillin or penicillin and gentamicin because of the high risk of severe infections. Experts have suggested, based on available evidence, ... -
The MHC-II transactivator CIITA, a viral restriction factor inhibiting the replication of Human T-Cell Lymphotropic Virus Type 1
(Conference lecture, 2011-06-06) -
Microbiological and bioinformatics analysis of primary Sjogren's syndrome patients with normal salivation
(Peer reviewed; Journal article, 2016-10-20)Background: Reduced salivation is considered a major clinical feature of most but not all cases of primary Sjögren’s syndrome (pSS). Reduced saliva flow may lead to changes in the salivary microbiota. These changes have ... -
Microheterogeneity and preanalytical stability of protein biomarkers of inflammation and renal function
(Journal article; Peer reviewed, 2021)Protein biomarker microheterogeneity has attracted increasing attention in epidemiological and clinical research studies. Knowledge concerning the preanalytical stability of proteins is paramount to assess the biological ... -
Micronutrients in paediatric Intestinal Failure Patients receiving home parenteral nutrition
(Journal article; Peer reviewed, 2020-11)Background & aims Children with intestinal failure (IF) receive parental nutrition to ensure adequate growth and development. The aim of this study was to assess micronutrient status in paediatric IF patients receiving ... -
A MicroRNA Linking Human Positive Selection and Metabolic Disorders
(Journal article; Peer reviewed, 2020)Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.3 locus is also ... -
MicroRNA serum profiles and chronic graft-versus-host disease
(Journal article; Peer reviewed, 2022)Chronic graft-versus-host disease (cGVHD) is the most common long-term complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). During the last decade, the interest of micro RNAs (miRNAs) in the ... -
MicroRNAs enrichment in GWAS of complex human phenotypes
(Peer reviewed; Journal article, 2015-04-16)Background: The genotype information carried by Genome-wide association studies (GWAS) seems to have the potential to explain more of the ‘missing heritability’ of complex human phenotypes, given improved statistical ... -
miR-486-5p expression is regulated by DNA methylation in osteosarcoma
(Journal article; Peer reviewed, 2022)Background Osteosarcoma is the most common primary malignant tumour of bone occurring in children and young adolescents and is characterised by complex genetic and epigenetic changes. The miRNA miR-486-5p has been shown ... -
Mismatch repair markers in preoperative and operative endometrial cancer samples; expression concordance and prognostic value
(Journal article; Peer reviewed, 2022)Background The endometrial cancer mismatch repair (MMR) deficient subgroup is defined by loss of MSH6, MSH2, PMS2 or MLH1. We compare MMR status in paired preoperative and operative samples and investigate the prognostic ...