Blar i Department of Clinical Science på tittel

Viser treff 1565-1584 av 2340

    • A novel, single-amplification PCR targeting mitochondrial genome highly sensitive and specific in diagnosing malaria among returned travellers in Bergen, Norway 

      Haanshuus, Christel Gill; Mohn, Stein Christian; Mørch, Kristine; Langeland, Nina; Blomberg, Bjørn; Hanevik, Kurt (Peer reviewed; Journal article, 2013-01-22)
      Background: Nested PCR is a commonly used technique in diagnosis of malaria owing to its high sensitivity and specificity. However, it is time-consuming, open to considerable risk of contamination and has low cost-efficiency. ...

    • NPM1-Mutated Patient-Derived AML Cells Are More Vulnerable to Rac1 Inhibition 

      Hemsing, Anette Lodvir; Rye, Kristin Paulsen; Hatfield, Kimberley Joanne; Reikvam, Håkon (Journal article; Peer reviewed, 2022)
      The prognosis of acute myeloid leukemia (AML) is poor, especially for the elderly population. Targeted therapy with small molecules may be a potential strategy to overcome chemoresistance and improve survival in AML. We ...

    • NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients 

      Borgen, Elin; Rypdal, Maria Christine; Sosa, Maria Soledad; Renolen, Anne; Schlichting, Ellen; Lønning, Per Eystein; Synnestvedt, Marit; Aguirre-Ghiso, Julio; Naume, Bjørn (Peer reviewed; Journal article, 2018-10-16)
      Background: The presence of disseminated tumor cells (DTCs) in bone marrow (BM) is an independent prognostic factor in early breast cancer but does not uniformly predict outcome. Tumor cells can persist in a quiescent state ...

    • Nuclear Receptor Coregulators Role of Protein-Protein Interactions and cAMP/PKA Signaling 

      Hoang, Tuyen Thi Van (Doctoral thesis, 2007-02-02)

    • Nurse-led consultations reinforced with eHealth technology: a qualitative study of the experiences of patients with gynecological cancer 

      Skorstad, Mette; Vistad, Ingvild; Fegran, Liv; Berntsen, Sveinung; Johannessen, Berit (Journal article; Peer reviewed, 2022-11-25)
      Background: During the last decade, the health care profession has moved toward personalized care and has focused on the diversity of survivorship needs after initial cancer treatment. Health care providers encourage ...

    • The nurse`s role in palliative care: A qualitative meta-synthesis 

      Sekse, Ragnhild Johanne Tveit; Hunskår, Irene; Ellingsen, Sidsel (Peer reviewed; Journal article, 2017)
      Aims and objectives: To explore how nurses, across various health systems, describe their role in providing palliative care for patients with life-threatening illnesses. Background: Despite the fact that nurses make up the ...

    • Nurses as adverse drug reaction reporting advocates 

      Schjøtt, Jan Didrik; Pettersen, Trond Røed; Andreassen, Lillan Mo; Bjånes, Tormod Karlsen (Journal article; Peer reviewed, 2022)
      Adverse drug reactions (ADRs) is a challenge in modern healthcare, particularly given the increasing complexity of drug therapy, an ageing population, rising multimorbidity, and a high patient turnover. The core activity ...

    • Nutritional risk in a university hospital. Challenges and consequences in clinical practice 

      Tangvik, Randi Julie (Doctoral thesis, 2015-03-25)
      Introduction: Malnutrition is present in 20-50% of hospitalised patients, leading to increased risk for adverse clinical outcomes and even mortality. Nutritional status is often ignored during hospitalisation. The Bergen ...

    • Nutritional risk profile in a university hospital population 

      Tangvik, Randi Julie; Tell, Grethe Seppola; Guttormsen, Anne Berit; Eisman, John A.; Henriksen, Andreas; Nilsen, Roy Miodini; Ranhoff, Anette Hylen (Peer reviewed; Journal article, 2015)
      Background & aims: The prevalence of nutritional risk varies according to several factors. We aimed to determine the nutritional risk profile in a large Norwegian hospital population, specifically by age, disease category ...

    • The nutritional strategy: four questions predict morbidity, mortality and health care costs 

      Tangvik, Randi Julie; Tell, Grethe Seppola; Eisman, John A.; Guttormsen, Anne Berit; Henriksen, Andreas; Nilsen, Roy Miodini; Øyen, Jannike; Ranhoff, Anette Hylen (Peer reviewed; Journal article, 2014-08)
      Background Nutritional care for hospital in-patients is potentially important but challenging. Objective To investigate the association between nutritional status and clinical outcomes. Methods Eight prevalence surveys ...

    • Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue 

      Meen, Astri Jeanette; Doncheva, Atanaska Ivanova; Böttcher, Yvonne; Dankel, Simon N; Hoffmann, Anne; Blüher, Matthias; Fernø, Johan; Mellgren, Gunnar; Ghosh, Adhideb; Sun, Wenfei; Dong, Hua; Noé, Falko; Wolfrum, Christian; Pejler, Gunnar; Dalen, Knut Tomas; Kolset, Svein Olav (Journal article; Peer reviewed, 2023)
      Proteoglycans are central components of the extracellular matrix (ECM) and binding partners for inflammatory chemokines. Morphological differences in the ECM and increased inflammation are prominent features of the white ...

    • Obesity wars: hypothalamic sEVs a new hope 

      Mukherjee, Sayani; Diéguez, Carlos; Fernø, Johan; López, Miguel (Journal article; Peer reviewed, 2023)
      There are currently several pharmacological therapies available for the treatment of obesity, targeting both the central nervous system (CNS) and peripheral tissues. In recent years, small extracellular vesicles (sEVs) ...

    • Obesity-associated changes in molecular biology of primary breast cancer 

      Nguyen, Ha-Linh; Geukens, Tatjana; Maetens, Marion; Aparicio, Samuel; Bassez, Ayse; Borg, Ake; Brock, Jane; Broeks, Annegien; Caldas, Carlos; Cardoso, Fatima; De Schepper, Maxim; Delorenzi, Mauro; Drukker, Caroline A.; Glas, Annuska M.; Green, Andrew R.; Isnaldi, Edoardo; Eyfjörð, Jórunn; Khout, Hazem; Knappskog, Stian; Krishnamurthy, Savitri; Lakhani, Sunil R.; Langerød, Anita; Martens, John W. M.; McCart Reed, Amy E.; Murphy, Leigh; Naulaerts, Stefan; Nik-Zainal, Serena; Nevelsteen, Ines; Neven, Patrick; Piccart, Martine; Poncet, Coralie; Punie, Kevin; Purdie, Colin; Rakha, Emad A.; Richardson, Andrea; Rutgers, Emiel; Vincent-Salomon, Anne; Simpson, Peter T.; Schmidt, Marjanka K.; Sotiriou, Christos; Span, Paul N.; Tan, Kiat Tee Benita; Thompson, Alastair; Tommasi, Stefania; Van Baelen, Karen; Van de Vijver, Marc; Van Laere, Steven; van’t Veer, Laura; Viale, Giuseppe; Viari, Alain; Vos, Hanne; Witteveen, Anke T.; Wildiers, Hans; Floris, Giuseppe; Garg, Abhishek D.; Smeets, Ann; Lambrechts, Diether; Biganzoli, Elia; Richard, François; Desmedt, Christine (Journal article; Peer reviewed, 2023)
      Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of ...

    • Occult obstructive coronary artery disease is associated with prolonged cardiac troponin elevation following strenuous exercise 

      Kleiven, Øyunn; Omland, Torbjørn; Skadberg, Øyvind; Melberg, Tor Harald; Bjørkavoll-Bergseth, Magnus; Auestad, Bjørn Henrik; Bergseth, Rolf; Greve, Ole Jacob; Aakre, Kristin Moberg; Ørn, Stein (Peer reviewed; Journal article, 2019)
      Background: Sudden cardiac death among middle-aged recreational athletes is predominantly due to myocardial ischaemia. This study examined whether measuring cardiac troponin I and T (cTnI and cTnT) after strenuous exercise ...

    • Ocrelizumab and ofatumumab, but not rituximab, trigger complement induction in vitro 

      Førde, Jan-Lukas; Herfindal, Lars; Myhr, Kjell-Morten; Torkildsen, Øivind; Mollnes, Tom Eirik; Skrede, Silje (Journal article; Peer reviewed, 2023)
      The clinical and adverse effects of the therapeutic monoclonal antibodies (mAb) ocrelizumab, ofatumumab and rituximab in multiple sclerosis (MS) are presently subject to extensive study. While the two former are approved ...

    • Octogenarian patients’ sleep and delirium experiences in hospital and four years after aortic valve replacement: a qualitative interview study 

      Amofah, Hege Andersen; Broström, Anders; Instenes, Irene; Fridlund, Bengt; Haaverstad, Rune; Kuiper, Karel Kier-Jan; Ranhoff, Anette Hylen; Norekvål, Tone Merete (Journal article; Peer reviewed, 2021)
      Objectives Sleep disturbances and delirium are frequently observed complications after surgical aortic valve replacement (SAVR) and transcutaneous aortic valve implantation (TAVI), especially in octogenarian patients. ...

    • Olaparib monotherapy as primary treatment in unselected triple negative breast cancer 

      Eikesdal, Hans Petter; Yndestad, Synnøve; Elzawahry, Asmaa; Llop-Guevara, Alba; Gilje, Bjørnar; Blix, Egil Støre; Espelid, Helge; Lundgren, Steinar; Geisler, Jürgen; Vagstad, Geirfinn; Venizelos, Andreas; Minsaas, Laura; Leirvaag, Beryl; Gudlaugsson, Einar; Vintermyr, Olav Karsten; Aase, Hildegunn Siv; Aas, Turid; Balmaña, Judith; Serra, Violeta; Janssen, Emiel; Knappskog, Stian; Lønning, Per Eystein (Journal article; Peer reviewed, 2020)
      Background The antitumor efficacy of PARP inhibitors (PARPi) for breast cancer patients harboring germline BRCA1/2 (gBRCA1/2) mutations is well established. While PARPi monotherapy was ineffective in patients with metastatic ...

    • Older patients’ perspectives on illness and healthcare during the early phase of the COVID-19 pandemic 

      Jøranson, Nina; Heggestad, Anne Kari Tolo; Lausund, Hilde; Breievne, Grete; Bruun-Olsen, Vigdis; Heiberg, Kristi Elisabeth; Myrstad, Marius; Ranhoff, Anette Hylen (Journal article; Peer reviewed, 2022)
      Background Equal access to healthcare is a core principle in Norway’s public healthcare system. The COVID-19 pandemic challenged healthcare systems in the early phase – in particular, related to testing and hospital ...

    • On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families 

      Eilertsen, Espen Moen; Gillespie Cheesman, Rosa Catherine; Ayorech, Ziada; Røysamb, Espen; Pingault, Jean-Baptiste; Njølstad, Pål Rasmus; Andreassen, Ole; Havdahl, Alexandra Karoline Saasen; McAdams, Tom A.; Torvik, Fartein Ask; Ystrøm, Eivind (Journal article; Peer reviewed, 2022)
      Background: Theoretical models of the development of childhood externalizing disorders emphasize the role of parents. Empirical studies have not been able to identify specific aspects of parental behaviors explaining a ...

    • One-year impact of bariatric surgery on left ventricular mechanics: results from the prospective FatWest study 

      Grymyr, Lisa Marie Dale; Nadirpour, Saied; Gerdts, Eva; Nedrebø, Bjørn Gunnar; Hjertaas, Johannes Just; Matre, Knut; Cramariuc, Dana (Journal article; Peer reviewed, 2021)
      Aims Patients with severe obesity are predisposed to left ventricular (LV) hypertrophy, increased myocardial oxygen demand, and impaired myocardial mechanics. Bariatric surgery leads to rapid weight loss and improves ...