Blar i Department of Clinical Science på tittel

Viser treff 1971-1990 av 2340

    • Role of Adipocyte SLC7A10 and Amino Acid Metabolism in Obesity and Insulin Resistance 

      Jersin, Regine Åsen (Doctoral thesis, 2020-12-18)
      Obesity is a rising global concern, associated with increased risk of developing metabolic syndrome, insulin resistance and type 2 diabetes. Chronic availability of excess nutrients may promote adipocyte dysfunction, ...

    • The role of anti-citrullinated protein antibody reactivities in an inception cohort of patients with rheumatoid arthritis receiving treat-to-target therapy 

      Jonsson, Maria Karolina; Hensvold, Aase Haj; Hansson, Monika; Aga, Anna-Birgitte; Sexton, Joseph; Mathsson-Alm, Linda; Cornillet, Martin; Serre, Guy; Lillegraven, Siri; Fevang, Bjørg-Tilde Svanes; Catrina, Anca Irinel; Haavardsholm, Espen A. (Peer reviewed; Journal article, 2018-07-13)
      Background: Anti-citrullinated protein antibody (ACPA) reactivities precede clinical onset of rheumatoid arthritis (RA), and it has been suggested that ACPA reactivities towards distinct target proteins may be associated ...

    • The role of arginine and arginine-metabolizing enzymes during Giardia - host cell interactions in vitro 

      Stadelmann, Britta; Hanevik, Kurt; Andersson, Mattias; Bruserud, Øystein; Svärd, Staffan G. (Peer reviewed; Journal article, 2013-11-14)
      Background: Arginine is a conditionally essential amino acid important in growing individuals and under nonhomeostatic conditions/disease. Many pathogens interfere with arginine-utilization in host cells, especially nitric ...

    • Role of dietary carbohydrate quality and quantity in visceral obesity reduction : Results from a randomized controlled trial (CARBFUNC) 

      Horn, Cathrine (Doctoral thesis, 2022-03-25)
      Background: Increased visceral adipose tissue (VAT) volume is associated with common lifestyle diseases and poses an increasing health challenge worldwide. There is a great need for effective approaches that result in ...

    • The role of dietary fat and carbohydrates in development of adipose tissue inflammation 

      Ngo, Ha Thi (Master thesis, 2009-06-02)
      Obesity is considered as a chronic low-grade inflammatory condition, which can be characterized by increased levels of the proinflammatory cytokines such as TNF-α and IL-6, and macrophage infiltration in adipose tissue. ...

    • Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development 

      Jones, Allison; Teschendorff, Andrew E.; Li, Quanxi; Hayward, Jane D.; Kannan, Athilakshmi; Mould, Tim; West, James; Zikan, Michal; Cibula, David; Fiegl, Heidi; Lee, Shih-Han; Wik, Elisabeth; Hadwin, Richard; Arora, Rupali; Lemech, Charlotte; Turunen, Henna; Pakarinen, Päivi; Jacobs, Ian J.; Salvesen, Helga Birgitte; Bagchi, Milan K.; Bagchi, Indrani C.; Widschwendter, Martin (Peer reviewed; Journal article, 2013-11-12)
      Background: Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. ...

    • Role of fungal burden in risk stratification of HIV-negative patients with Pneumocystis pneumonia: A 12-year, retrospective, observational, multicenter cohort 

      Grønseth, Stine; Rogne, Tormod; Heggelund, Lars; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Journal article; Peer reviewed, 2023)
      Objectives This study aimed to explore the role of fungal burden in risk stratification of patients without HIV-negative patients with Pneumocystis pneumonia (PCP). Methods This was a retrospective analysis of the ...

    • The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts 

      Hou, Ruihua; Ye, Gang; Cheng, Xiaojing; Shaw, Dominick E.; Bakke, Per S.; Caruso, Massimo; Dahlen, Barbro; Dahlen, Sven-Erik; Fowler, Stephen J.; Horváth, Ildikó; Howarth, Peter; Krug, Norbert; Montuschi, Paolo; Sanak, Marek; Sandström, Thomas; Auffray, Charles; De Meulder, Bertrand; Sousa, Ana R.; Adcock, Ian M.; Fan Chung, Kian; Sterk, Peter J.; Skipp, Paul J.; Schofield, James; Djukanović, Ratko (Journal article; Peer reviewed, 2023)
      Background: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the ...

    • The role of interleukin-6 classical and trans-signaling in allogeneic stem cell transplantation 

      Tvedt, Tor Henrik Anderson (Doctoral thesis, 2020-04-02)
      IL-6 family cytokines share structural similarities and utilize glycoprotein 130 (gp130) for signal transduction. IL-6 itself has both pro- and anti-inflammatory effects. IL-6 trans-signaling is mediated by the soluble ...

    • The Role of Long-Chained Marine N-3 Polyunsaturated Fatty Acids in Cardiovascular Disease 

      Aarsetøy, Hildegunn; Grundt, Heidi; Nygård, Ottar; Nilsen, Dennis W.T. (Peer reviewed; Journal article, 2012)
      This paper reviews the current evidence regarding long-chained marine omega-3 polyunsaturated fatty acids (PUFAs) and cardiovascular disease (CVD), their possible mechanisms of action, and results of clinical trials. Also, ...

    • Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study 

      Magnus, Maria Christine; Wilcox, Allen J; Morken, Nils-Halvdan; Weinberg, Clarice R.; Håberg, Siri Eldevik (Peer reviewed; Journal article, 2019)
      Objectives: To estimate the burden of miscarriage in the Norwegian population and to evaluate the associations with maternal age and pregnancy history. Design: Prospective register based study. Setting: Medical Birth ...

    • The role of microRNAs as predictors of response to tamoxifen treatment in breast cancer patients 

      Egeland, Nina; Lunde, Siri; Jonsdottir, Kristin; Lende, Tone Hoel; Cronin-Fenton, Deirdre P.; Gilje, Bjørnar; Janssen, Emilius Adrianus Maria; Søiland, Håvard (Peer reviewed; Journal article, 2015-10-14)
      Endocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. However, resistance to endocrine therapy leads to breast cancer relapse. The recent extension of adjuvant tamoxifen ...

    • The role of NF-κB transcription factor in cellular response to ionizing radiation 

      Janus, Patryk; Szoltysek, Katarzyna; Zajac, Gracjana; Widlak, Wieslawa; Stokowy, Tomasz; Wojtas, Bartosz; Widlak, Piotr (Journal article, 2019)
      The NF-κB transcription factor is involved in different aspects of the cellular response to stress, including atypical NF-κB pathway activated by damage induced by ionizing radiation. Moreover, NF-κB could be involved in ...

    • The role of PTEN, PI3K-Akt-mTOR signaling and pseudogene PTENP1 in breast cancer 

      Yndestad, Synnøve (Doctoral thesis, 2018-04-19)
      Background: Breast cancer is the most common type of cancer in women, and a major cause of premature death still today. The PI3K-Akt-mTOR signaling (in short: PI3K signaling) pathway is a growth and pro-survival pathway, ...

    • Role of rare HNF1A variants function in monogenic and type 2 diabetes 

      Najmi, Laeya Abdoli (Doctoral thesis, 2018-10-26)
      Variants in the transcription factor gene HNF1A have been identified in subjects with maturity-onset diabetes of the young (MODY) type 3, type 2 diabetes, as well as in children with apparent type 1 diabetes. One of the ...

    • Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance 

      Jersin, Regine Åsen; Tallapragada, Divya Sri Priyanka; Madsen, André; Skartveit, Linn; Fjære, Even; McCann, Adrian; Dyer, Laurence; Willems, Aron; Bjune, Jan-Inge; Bjune, Mona Synnøve; Våge, Villy; Nielsen, Hans Jørgen; Thorsen, Håvard Luong; Nedrebø, Bjørn Gunnar; Busch, Christian; Steen, Vidar M.; Blüher, Matthias; Jacobson, Peter; Svensson, Per-Arne; Fernø, Johan; Rydén, Mikael; Arner, Peter; Nygård, Ottar; Claussnitzer, Melina; Ellingsen, Ståle; Madsen, Lise; Sagen, Jørn V.; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2021)
      Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes and other obesity-related diseases. Here, we find that adipose ...

    • Rosuvastatin alters the genetic composition of the human gut microbiome 

      Kummen, Martin; Solberg, Ole Geir; Larsen, Christopher Storm; Holm, Kristian; Ragnarsson, Asgrimur; Trøseid, Marius; Vestad, Beate; Skårdal, Rita; Yndestad, Arne; Ueland, Thor; Svardal, Asbjørn M.; Berge, Rolf Kristian; Seljeflot, Ingebjørg; Gullestad, Lars; Karlsen, Tom Hemming; Aaberge, Lars; Aukrust, Pål; Hov, Johannes Espolin Roksund (Journal article; Peer reviewed, 2020)
      The gut microbiome contributes to the variation of blood lipid levels, and secondary bile acids are associated with the effect of statins. Yet, our knowledge of how statins, one of our most common drug groups, affect the ...

    • Runaway multi-allelic copy number variation at the α-defensin locus in African and Asian populations 

      Hughes, Timothy; Hansson, Lars; Akkouh, Ibrahim; Hajdarevic, Riad; Bringsli, Jorunn; Torsvik, Anja; Inderhaug, Elin; Steen, Vidar Martin; Djurovic, Srdjan (Journal article; Peer reviewed, 2020-06-04)
      Alpha defensins are anti-microbial peptides of the innate immune system. The defensin A1 and A3 genes are located in a repeat array of variable copy number (the DEFA1A3 locus) and encode the human neutrophil peptides 1, 2 ...

    • S100 proteins in acute myeloid leukemia 

      Brenner, Annette; Bruserud, Øystein (Peer reviewed; Journal article, 2018-12)
      The S100 protein family contains 20 functionally expressed members, which are commonly dysregulated in cancer. Their wide range of functions includes cell proliferation, cell differentiation, regulation of transcription ...

    • Safety and efficacy of faecal microbiota transplantation by Anaerobic Cultivated Human Intestinal Microbiome (ACHIM) in patients with systemic sclerosis: Study protocol for the randomised controlled phase II ReSScue trial 

      Hoffmann-Vold, Anna-Maria; Fretheim, Håvard Halland; Sarna, Vikas Kumar; Barua, Imon Shoumitra; Carstens, Maylen N.; Distler, Oliver; Khanna, Dinesh; Volkmann, Elizabeth R.; Midtvedt, Øyvind; Didriksen, Henriette; Dhainaut, Alvilde; Halse, Anne Kristine Hjorteseth; Bakland, Gunnstein; Pesonen, Maiju; Olsen, Inge Christoffer; Molberg, Øyvind (Journal article; Peer reviewed, 2021)
      Introduction: In the multisystem inflammatory disorder systemic sclerosis (SSc), gastrointestinal tract (GIT) affliction is highly prevalent. There are no known disease modifying therapies and the negative impact is ...