Browsing Department of Clinical Science by Title

Now showing items 2133-2152 of 2340

    • Supporting safe medicines transition for residents entering care homes 

      Kandiah, Janani (Master thesis, 2021-05-20)

    • Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis 

      Braadland, Peder Rustøen; Schneider, Kai Markus; Bergquist, Annika; Molinaro, Antonio; Lövgren-Sandblom, Anita; Henricsson, Marcus; Karlsen, Tom Hemming; Vesterhus, Mette Nåmdal; Trautwein, Christian; Hov, Johannes Espolin Roksund; Marschall, Hanns-Ulrich (Journal article; Peer reviewed, 2022)
      Background & Aims: Farnesoid X receptor (FXR) agonists and fibroblast growth factor 19 (FGF19) analogues suppress bile acid synthesis and are being investigated for their potential therapeutic efficacy in cholestatic liver ...

    • Surgical Treatment of Severe Bowel Obstruction as a Rare Complication Following Allogenic Hematopoietic Stem Cell Transplantation 

      Reikvam, Håkon; Tvedt, Tor Henrik Anderson; Johansen, Silje; Setran, Hege Aase; Havre, Roald Flesland (Journal article, 2020)
      Gastrointestinal graft-versus-host disease (GVHD) and cytomegalovirus (CMV) disease are common complications occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and contribute to a high degree ...

    • A survey of surgical team members' perceptions of near misses and attitudes towards Time Out protocols 

      Haugen, Arvid Steinar; Murugesh, Shamini; Haaverstad, Rune; Eide, Geir Egil; Søfteland, Eirik (Peer reviewed; Journal article, 2013-10-09)
      Background: Medical errors are inherently of concern in modern health care. Although surgical errors as incorrect surgery (e.g., wrong patient, wrong site, or wrong procedure) are infrequent, they are devastating events ...

    • A survey of total IgE reference intervals reported by Scandinavian and British medical laboratories – a need for harmonisation 

      Vinnes, Erik Wilhelm; Sletten, Ida Sofie Karlsen; Alnæs, Marie Bjørbak; Storaas, Torgeir; Aarsand, Aasne Karine (Journal article; Peer reviewed, 2023)
      Objectives There appears to be marked discrepancies between total IgE reference intervals (RIs) in use by many laboratories and those recommended by published studies. The aim of this study was therefore to review total ...

    • Survival According to Primary Tumor Location, Stage, and Treatment Patterns in Locoregional Gastroenteropancreatic High-grade Neuroendocrine Carcinomas 

      Dasari, Arvind; Shen, Chan; Devabhaktuni, Anjali; Nighot, Ruda; Sorbye, Halfdan (Journal article; Peer reviewed, 2022)
      Background: Although the gastrointestinal tract (including the pancreas, gastroenteropancreatic (GEP) is the most common site for extrapulmonary neuroendocrine carcinoma (NEC), the current treatment patterns of locoregional ...

    • Survival after aortic root replacement with a stentless xenograft is determined by patient characteristics 

      Dagnegård, Hanna H.; Bekke, Kirstine; Kolseth, Solveig Moss; Glaser, Natalie; Wallén, Christoffer; El-Hamamsy, Ismail; Vidisson, Kristjan O.; Lie, Asbjørn Sigstad; Valentin, Jan; Sartipy, Ulrik; Haaverstad, Rune; Vanky, Farkas; Lefebvre, Laurence; Gudbjartsson, Tomas; Johnsen, Søren P.; Søndergaard, Lars; Thyregod, Gustav H.; Lund, Jens T.; Ihlemann, Nikolaj; Smerup, Morten H. (Journal article; Peer reviewed, 2021)
      Objectives Our objective was to examine intermediate-term survival and reinterventions in unselected patients, stratified according to indication, who received a Freestyle (Medtronic Inc, Minneapolis, Minn) bioprosthesis ...

    • Survival and costs of colorectal cancer treatment and effects of changing treatment strategies: a model approach 

      Joranger, Pål; Nesbakken, Arild; Sorbye, Halfdan; Hoff, Geir; Oshaug, Arne; Aas, Eline (Peer reviewed; Journal article, 2020)
      New and emerging advances in colorectal cancer (CRC) treatment combined with limited healthcare resources highlight the need for detailed decision-analytic models to evaluate costs, survival and quality-adjusted life years. ...

    • Survival and death causes of patients with giant cell arteritis in Western Norway 1972-2012: a retrospective cohort study 

      Brekke, Lene Kristin; Fevang, Bjørg-Tilde Svanes; Diamantopoulos, Andreas P; Assmus, Jörg; Esperø, Elisabet Langseth; Gjesdal, Clara Gram (Peer reviewed; Journal article, 2019-06-25)
      Background: Our objective was to determine the survival and causes of death in a large and well-characterized cohort of patients with giant cell arteritis (GCA). Methods: This is a hospital-based, retrospective, observational ...

    • Susceptibility to chronic mucus hypersecretion, a genome wide association study 

      Dijkstra, Akkelies E.; Smolonska, J; Van Den Berge, M; Wijmenga, C; Zanen, P; Luinge, MA; Platteel, M; Lammers, JW; Dahlback, M; Tosh, K; Hiemstra, PS; Sterk, PJ; Spira, A; Vestbo, J; Nordestgaard, BG; Benn, M; Nielsen, SF; Dahl, M; Verschuren, WM; Picavet, HSJ; Smit, HA; Owsijewitsch, M; Kauczor, HU; De Koning, HJ; Nizankowska-Mogilnicka, E; Mejza, F; Nastalek, P; Van Diemen, CC; Cho, MH; Silverman, EK; Crapo, JD; Beaty, TH; Lomas, DA; Bakke, Per; Gulsvik, Amund; Bosse, Y; Obeidat, MA; Loth, DW; Lahousse, L; Rivadeneira, F; Uitterlinden, AG; Hofman, A; Stricker, BH; Brusselle, GG; Van Duijn, CM; Brouwer, U; Koppelman, GH; Vonk, JM; Nawijn, MC; Groen, HJM; Timens, W; Boezen, HM; Postma, DS; Alizadeh, BZ; De Boer, RA; Bruinenberg, M; Franke, L; Van Der Harst, P; Hillege, HL; Van Der Klauw, MM; Navis, G; Ormel, J; Rosmalen, J; Slaets, JP; Snieder, H; Stolk, RP; Wolffenbuttel, B (Peer reviewed; Journal article, 2014-04-08)
      Background: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. ...

    • Susceptibility to hormone-mediated cancer is reflected by different tick rates of the epithelial and general epigenetic clock 

      Barrett, James E.; Herzog, Chiara; Kim, Yoo-Na; Bartlett, Thomas E.; Jones, Allison; Evans, Iona; Cibula, David; Zikan, Michal; Bjørge, Line; Harbeck, Nadia; Colombo, Nicoletta; Howell, Sacha J.; Rådestad, Angelique Flöter; Gemzell-Danielsson, Kristina; Widschwendter, Martin (Journal article; Peer reviewed, 2022)
      Background A variety of epigenetic clocks utilizing DNA methylation changes have been developed; these clocks are either tissue-independent or designed to predict chronological age based on blood or saliva samples. Whether ...

    • Switch from stress response to homeobox transcription factors in Adipose tissue after profound fat loss 

      Dankel, Simon N; Fadnes, Dag J.; Stavrum, Anne-Kristin; Stansberg, Christine; Holdhus, Rita; Hoang, Tuyen Thi Van; Veum, Vivian L.; Christensen, Bjørn Jostein; Våge, Villy; Sagen, Jørn V.; Steen, Vidar Martin; Mellgren, Gunnar (Peer reviewed; Journal article, 2010-06-09)
      Background In obesity, impaired adipose tissue function may promote secondary disease through ectopic lipid accumulation and excess release of adipokines, resulting in systemic low-grade inflammation, insulin resistance ...

    • Switch in FOXA1 status associates with endometrial cancer progression 

      Tangen, Ingvild Løberg; Krakstad, Camilla; Halle, Mari Kyllesø; Werner, Henrica Maria Johanna; Øyan, Anne Margrete; Kusonmano, Kanthida; Petersen, Kjell; Kalland, Karl-Henning; Akslen, Lars A.; Trovik, Jone; Rodriguez, Antoni Hurtado; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2014-05-21)
      Background: The transcription factor Forkhead box A1 (FOXA1) is suggested to be important in hormone dependent cancers, although with little data for endometrial cancer. We investigated expression levels of FOXA1 in primary ...

    • Symptom burden and immune dynamics 6 to 18 months following mild SARS-CoV-2 infection -a case-control study 

      Fjelltveit, Elisabeth Berg; Blomberg, Bjørn; Kuwelker, Kanika; Zhou, Fan; Onyango, Therese Bredholt; Brokstad, Karl Albert; Elyanow, Rebecca G; Kaplan, Ian; Tøndel, Camilla; Mohn, Kristin Greve-Isdahl; Özgümüs, Türküler; Cox, Rebecca Jane; Langeland, Nina (Journal article; Peer reviewed, 2022)
      Background The burden and duration of persistent symptoms after nonsevere coronavirus disease 2019 (COVID-19) remains uncertain. This study aimed to assess postinfection symptom trajectories in home-isolated COVID-19 cases ...

    • Symptomatic and asymptomatic secondary transmission of Cryptosporidium parvum following two related outbreaks in schoolchildren 

      Johansen, Øystein Haarklau; Hanevik, Kurt; Thrana, F.; Carlson, A; Stachurska-Hagen, Teresa; Skaare, Dagfinn; Robertson, Lucy J (Peer reviewed; Journal article, 2015-06)
      Two related outbreaks (in 2009 and 2012) of cryptosporidiosis in Norwegian schoolchildren during a stay at a remote holiday farm provided us with a natural experiment to investigate possible secondary transmission of ...

    • Symptomer etter inntak av karbohydrater. En sammenligning av laktulose og glukose hos pasienter med selvrapportert matoverfølsomhet 

      Vik, Natalia Samulski (Master thesis, 2009-09-16)
      Bakgrunn: Unormale reaksjoner på inntak av mat rapporteres hos opptil 25 % av befolkningen, men kun et fåtall av disse har ekte matvareallergi. IBS (irritabel tarm) er en kronisk og plagsom, men i seg selv ufarlig lidelse, ...

    • Symptomer og malabsorpsjon hos pasienter med selvrapportert matoverfølsomhet etter inntak av fruktose og sorbitol - en sammenligning av pasienter med selvrapportert matoverfølsomhet og friske kontroller 

      Frøvik, Birgitte (Master thesis, 2007)
      Rundt 25 % av befolkningen i den vestlige verden opplever gastrointestinale plager i forbindelse med matinntak. De fleste av disse har ikke matallergi. Malabsorpsjon av fruktose og sorbitol er foreslått som årsak til slike ...

    • Symptoms and antecedents of autism in children born extremely premature: a national population-based study 

      Fevang, Silje Katrine Elgen; Madland, Ada Røiseland; Elgen, Irene Bircow; Vollsæter, Maria; Hysing, Mari (Journal article; Peer reviewed, 2022)
      The objective of this study is to investigate the prevalence of autism (ASD) symptoms, i.e. , social difficulties, repetitive behaviors, and communicational problems, among children born extremely preterm (EP) compared to ...

    • Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal 

      Svensson, Mattias N.D.; Zoccheddu, Martina; Yang, Shen; Nygaard, Gyrid; Secchi, Christian; Doody, Karen M.; Slowikowski, Kamil; Mizoguchi, Fumitaka; Humby, Frances; Hands, Rebecca; Santelli, Eugenio; Sacchetti, Cristiano; Wakabayashi, Kuninobu; Wu, Dennis J.; Barback, Christopher; Ai, Rizi; Wang, Wei; Sims, Gary P.; Mydel, Piotr Mateusz; Kasama, Tsuyoshi; Boyle, David L.; Galimi, Francesco; Vera, David; Tremblay, Michel L.; Raychaudhuri, Soumya; Brenner, Michael B.; Firestein, Gary S.; Pitzalis, Costantino; Ekwall, Anna-Karin H.; Stanford, Stephanie M.; Bottini, Nunzio (Journal article; Peer reviewed, 2020)
      Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA) pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through systemic immunosuppression. FLS-targeted ...

    • Synthesis of some 1-substituted 5,5-diethoxy-2,2-(propyl-1,3-disulfanyl)pentane-1,4-diols from 1,1-diethoxy-3-(1,3-dithian-2-yl)-propan-2-ol 

      Flemmen, Guro (Master thesis, 2009-05-20)
      The starting material for this investigation was 3,3,4,4-tetraethoxybut-1-yne (TEB). This compound is highly functionalized as it contains a triple bond, a protected ketone, and a protected aldehyde, and can undergo a ...