Browsing Department of Clinical Science by Title

Now showing items 609-628 of 2340

    • Durable immune responses after BNT162b2 vaccination in home-dwelling old adults 

      Hansen, Lena; Brokstad, Karl Albert; Bansal, Amit; Zhou, Fan; Bredholt, Geir; Onyango, Therese Bredholt; Sandnes, Helene Heitmann; Elyanow, Rebecca; Madsen, Anders; Trieu, Mai Chi; Sævik, Marianne; Søyland, Hanne; Olofsson, Jan Stefan; Vahokoski, Juha; Ertesvåg, Nina Urke; Fjelltveit, Elisabeth Berg; Shafiani, Shahin; Tøndel, Camilla; Chapman, Heidi; Kaplan, Ian; Mohn, Kristin Greve-Isdahl; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)
      Objectives Elderly are an understudied, high-risk group vulnerable to severe COVID-19. We comprehensively analyzed the durability of humoral and cellular immune responses after BNT162b2 vaccination and SARS-CoV-2 infection ...

    • Duration of elevated heart rate Is an important predictor of exercise-induced troponin elevation 

      Bjørkavoll-Bergseth, Magnus; Kleiven, Øyunn; Auestad, Bjørn Henrik; Eftestøl, Trygve Christian; Oskal, Kay Raymond; Nygård, Martin; Skadberg, Øyvind; Aakre, Kristin Moberg; Melberg, Tor Harald; Gjesdal, Knut; Ørn, Stein (Journal article; Peer reviewed, 2020)
      Background The precise mechanisms causing cardiac troponin (cTn) increase after exercise remain to be determined. The aim of this study was to investigate the impact of heart rate (HR) on exercise‐induced cTn increase by ...

    • Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls 

      van der Does, Anne M; Heijink, Marieke; Mayboroda, Oleg A.; Persson, Louise Jeanette Pauline; Aanerud, Marianne; Bakke, Per S.; Eagan, Tomas Mikal; Hiemstra, Pieter S.; Giera, Martin (Peer reviewed; Journal article, 2019)
      Introduction: Disturbances in onset and resolution of inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. Dietary polyunsaturated fatty acids (PUFAs) can be converted into lipid mediators ...

    • Dynamics of circulating lymphocytes responding to human experimental enterotoxigenic Escherichia coli infection 

      Rim, Sehee; Sakkestad, Sunniva Todnem; Zhou, Fan; Gullaksen, Stein-Erik; Skavland, Jørn; Chauhan, Sudhir Kumar; Steinsland, Hans; Hanevik, Kurt (Journal article; Peer reviewed, 2023)
      Enterotoxigenic Escherichia coli (ETEC) is an important cause of children's and travelers’ diarrhea, with no licensed vaccine. This study aimed to explore the role of cellular immunity in protection against human ETEC ...

    • The dynamics of nutritional-related blood biomarker and metabolite concentrations during the postprandial and fasting states : And the implications when using nutritional-related biomarkers and metabolites in clinical care and research settings 

      Anfinsen, Åslaug Matre (Doctoral thesis, 2024-04-05)
      BAKGRUNN: Vi vet lite om hvordan ernæringsrelaterte biomarkører og metabolitter endrer seg i blodet i postprandiell og fastende tilstand. MÅL: Å undersøke hvordan konsentrasjonen av aminosyrer, en-karbon metabolitter, ...

    • Dysfunction of the protein quality control system in neurodegeneration: A study of the co-chaperone and ubiquitin ligase CHIP in vitro and in zebrafish 

      Pakdaman, Yasaman (Doctoral thesis, 2021-09-15)
      The C-terminus of Hsc70 interacting protein (CHIP) is a dimeric co-chaperone and E3 ubiquitin ligase encoded by the STIP1 homology and U-box containing protein 1 (STUB1) gene. As a major player in the protein quality control ...

    • Dyspnea, lung function and CT findings three months after hospital admission for COVID-19 

      Lerum, Tøri Vigeland; Aaløkken, Trond M; Brønstad, Eivind; Aarli, Bernt Bøgvald; Ikdahl, Eirik; Lund, Kristine Marie Aarberg; Durheim, Michael; Rivero, Jezabel Rodriguez; Meltzer, Carin; Tonby, Kristian; Stavem, Knut; Skjønsberg, Ole Henning; Ashraf, Haseem; Einvik, Gunnar (Journal article; Peer reviewed, 2021)
      The long-term pulmonary outcomes of coronavirus disease 2019 (COVID-19) are unknown. We aimed to describe self-reported dyspnoea, quality of life, pulmonary function and chest computed tomography (CT) findings 3 months ...

    • Dødsfall i sykehjem etter covid-19-vaksine 

      Wyller, Torgeir Bruun; Kittang, Bård Reiakvam; Ranhoff, Anette Hylen; Harg, Pernille; Myrstad, Marius (Journal article; Peer reviewed, 2021)
      Bakgrunn: I perioden 27.12.2020–15.2.2021 ble om lag 29 400 av Norges ca. 35 000 sykehjemspasienter vaksinert med mRNA-vaksinen BNT162b2. I samme tidsrom mottok Statens legemiddelverk 100 meldinger om mistenkte fatale ...

    • E-Learning. A study of students’ attitudes and learning outcome when using blended learning with integration of multimedia instructions 

      Rosenbaum, Paul-Erik Lillholm (Doctoral thesis, 2012-09-06)
      The advent of new technologies has provided opportunities and challenges for education institutions to seek more effective ways of teaching and learning. Elearning is now an established phenomenon in education and institutions ...

    • The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α 

      Kaci, Alba; Keindl, Magdalena; Solheim, Marie Holm; Njølstad, Pål Rasmus; Bjørkhaug, Lise; Aukrust, Ingvild (Peer reviewed; Journal article, 2018-08-24)
      The transcription factor hepatocyte nuclear factor-1α (HNF-1A) is involved in normal pancreas development and function. Rare variants in the HNF1A gene can cause monogenic diabetes, while common variants confer type 2 ...

    • Early empirical antibiotics and adverse clinical outcomes in infants born very preterm: A population-based cohort 

      Vatne, Anlaug; Hapnes, Nina; Stensvold, Hans Jørgen; Dalen, Ingvild; Guthe, Hans Jørgen Timm; Støen, Ragnhild; Brigtsen, Anne Karin; Rønnestad, Arild Erland; Klingenberg, Claus Andreas (Journal article; Peer reviewed, 2022)
      Objective: The objective of this study was to evaluate the association between empirical antibiotic therapy in the first postnatal week in uninfected infants born very preterm and the risk of adverse outcomes until ...

    • Early Gut Fungal and Bacterial Microbiota and Childhood Growth 

      Schei, Kasper; Simpson, Melanie Rae; Avershina, Ekaterina; Rudi, Knut; Øien, Torbjørn; Juliusson, Petur Benedikt; Underhill, David; Salamati, Saideh; Ødegård, Rønnaug (Journal article; Peer reviewed, 2020)
      Introduction: Childhood growth is a sensitive marker of health. Animal studies show increased height and weight velocity in the presence of fungal as well as antibiotic supplement in feed. Human studies on early gut ...

    • Early Induction of Cross-Reactive CD8+ T-Cell Responses in Tonsils After Live-Attenuated Influenza Vaccination in Children 

      Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Islam, Shahinul; Oftung, Fredrik; Tøndel, Camilla; Aarstad, Hans Jørgen; Cox, Rebecca Jane (Journal article; Peer reviewed, 2020)
      Background Live-attenuated influenza vaccine (LAIV) was licensed for prophylaxis of children 2–17 years old in Europe in 2012 and is administered as a nasal spray. Live-attenuated influenza vaccine induces both mucosal ...

    • Early life environment and snoring in adulthood 

      Franklin, Karl A.; Janson, Christer; Gíslason, Thórarinn; Gulsvik, Amund; Gunnbjörnsdottir, Maria; Lærum, Birger Norderud; Lindberg, Eva; Norrman, Eva; Nyström, Lennarth; Omenaas, Ernst; Torén, Kjell; Svanes, Cecilie (Peer reviewed; Journal article, 2008-08-22)
      Background: To our knowledge, no studies of the possible association of early life environment with snoring in adulthood have been published. We aimed to investigate whether early life environment is associated with snoring ...

    • Early life growth and associations with lung function and bronchial hyperresponsiveness at 11-years of age 

      Mikalsen, Ingvild Bruun; Halvorsen, Thomas; Juliusson, Pétur Benedikt; Magnus, Maria Christine; Nystad, Wenche; Stensrud, Trine; Størdal, Ketil; Vollsæter, Maria; Øymar, Knut Asbjørn Alexander (Journal article; Peer reviewed, 2021)
      Low birthweight and being born small-for-gestational age (SGA) are linked to asthma and impaired lung function. Particularly, poor intrauterine growth followed by rapid catch-up growth during childhood may predispose for ...

    • Early manifestations of genetic risk for neurodevelopmental disorders 

      Askeland, Ragna Bugge; Hannigan, Laurie J.; Ask, Helga; Ayorech, Ziada; Tesli, Martin Steen; Corfield, Elizabeth; Magnus, Per Minor; Njølstad, Pål Rasmus; Andreassen, Ole A.; Smith, George Davey; Reichborn-Kjennerud, Ted; Havdahl, Alexandra (Journal article; Peer reviewed, 2021)
      Background: Attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (autism) and schizophrenia are highly heritable neurodevelopmental disorders, affecting the lives of many individuals. It is important ...

    • Early outcome and restenosis after coronary stenting : intervention with stent-coatings, antioxidants and radiation 

      Kuiper, Karel Kier-Jan (Doctoral thesis, 2007-03-16)

    • Early radiologic signal of responsiveness to immune checkpoint blockade in microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer 

      Meltzer, Sebastian; Negård, Anne; Bakke, Kine Mari; Hamre, Hanne Mari; Kersten, Christian; Hofsli, Eva; Guren, Marianne; Sorbye, Halfdan; Flatmark, Kjersti; Ree, Anne Hansen (Journal article; Peer reviewed, 2022)
      Background: Immune checkpoint blockade (ICB) results in radiologic tumour response dynamics that differ from chemotherapy efficacy measures and require an early signal of clinical utility. Methods: Previously untreated, ...

    • Early response evaluation by single cell signaling profiling in acute myeloid leukemia 

      Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck; Gullaksen, Stein-Erik; Srivastava, Aashish; Birkeland, Even; Kleftogiannis, Dimitrios; Ayuda Duran, Pilar; Piechaczyk, Laure Isabelle; Tadele, Dagim Shiferaw; Skavland, Jørn; Panagiotis, Baliakas; Hovland, Randi; Andresen, Vibeke; Seternes, Ole Morten; Tvedt, Tor Henrik Anderson; Aghaeepour, Nima; Gavasso, Sonia; Porkka, Kimmo; Jonassen, Inge; Fløisand, Yngvar; Enserink, Jorrit; Blaser, Nello; Gjertsen, Bjørn Tore (Journal article; Peer reviewed, 2023)
      Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a ...

    • Early Response in Cellulitis: A Prospective Study of Dynamics and Predictors 

      Bruun, Trond; Oppegaard, Oddvar; Hufthammer, Karl Ove; Langeland, Nina; Skrede, Steinar (Peer reviewed; Journal article, 2016)
      Background: Skin and soft tissue infections are common reasons for medical care. Use of broad-spectrum therapy and costs have increased. Assessment of early treatment response has been given a central role both in clinical ...