Browsing Faculty of Medicine by Title
Now showing items 342-361 of 8854
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Apicomplexan actin polymerization depends on nucleation
(Peer reviewed; Journal article, 2017-09-22)Filamentous actin is critical for apicomplexan motility and host cell invasion. Yet, parasite actin filaments are short and unstable. Their kinetic characterization has been hampered by the lack of robust quantitative ... -
APOBEC3A/B deletion polymorphism and endometrial cancer risk
(Journal article; Peer reviewed, 2022)Background A common 30 kb deletion affecting the APOBEC3A and APOBEC3B genes has been linked to increased APOBEC activity and APOBEC-related mutational signatures in human cancers. The role of this deletion as a cancer ... -
The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity
(Peer reviewed; Journal article, 2010-08-06)Cyanobacteria (83 strains and seven natural populations) were screened for content of apoptosis (cell death)-inducing activity towards neoplastic cells of the immune (jurkat acute T-cell lymphoma) and hematopoetic (acute ... -
Apparent diffusion coefficient values in Modic changes – interobserver reproducibility and relation to Modic type
(Journal article; Peer reviewed, 2022)Background Modic Changes (MCs) in the vertebral bone marrow were related to back pain in some studies but have uncertain clinical relevance. Diffusion weighted MRI with apparent diffusion coefficient (ADC)-measurements ... -
Applicability of an abbreviated version of the Child-OIDP inventory among primary schoolchildren in Tanzania
(Peer reviewed; Journal article, 2007-07-13)Background: There is a need for studies evaluating oral health related quality of life (OHRQoL) of children in developing countries. Aim: to assess the psychometric properties, prevalence and perceived causes of the child ... -
Application of community dialogue approach to prevent adolescent pregnancy, early marriage and school dropout in Zambia: a case study
(Journal article; Peer reviewed, 2022)Background Adolescent pregnancy carries both health and economic risks for the pregnant girl and resulting baby, and it is common in Zambia. Providing alternative methods of preventing early pregnancy than abstinence is ... -
Application of virtual reality, augmented reality, and mixed reality in endourology and urolithiasis: An update by YAU endourology and Urolithiasis Working Group
(Journal article; Peer reviewed, 2022)The integration of virtual reality (VR), augmented reality (AR), and mixed reality (MR) in urological practices and medical education has led to modern training systems that are cost-effective and with an increased expectation ... -
Applications of Machine Learning in Human Microbiome Studies: A Review on Feature Selection, Biomarker Identification, Disease Prediction and Treatment
(Journal article; Peer reviewed, 2021)The number of microbiome-related studies has notably increased the availability of data on human microbiome composition and function. These studies provide the essential material to deeply explore host-microbiome associations ... -
Applying machine learning in motor activity time series of depressed bipolar and unipolar patients compared to healthy controls
(Journal article; Peer reviewed, 2020)Current practice of assessing mood episodes in affective disorders largely depends on subjective observations combined with semi-structured clinical rating scales. Motor activity is an objective observation of the inner ... -
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
(Peer reviewed; Journal article, 2018-10-08)Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the ... -
Applying the theory of planned behaviour to explain HIV testing in antenatal settings in Addis Ababa - a cohort study
(Peer reviewed; Journal article, 2011-08-18)Background: To facilitate access to the prevention of mother-to-child HIV transmission (PMTCT) services, HIV counselling and testing are offered routinely in antenatal care settings. Focusing a cohort of pregnant women ... -
Appraising Drugs Based on Cost-effectiveness and Severity of Disease in Norwegian Drug Coverage Decisions
(Journal article; Peer reviewed, 2022)Importance: Rising health care costs are a major health policy challenge globally. Norway has implemented a priority-setting system intended to balance cost-effectiveness and concerns for fair distribution, but little is ... -
Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum
(Peer reviewed; Journal article, 2016-01-04)The World Health Organization (WHO) calls for an accurate, rapid, and simple point-of-care (POC) test for the diagnosis of pediatric tuberculosis (TB) in order to make progress “Towards Zero Deaths”. Whereas the sensitivity ... -
Appropriate waist circumference cut points for identifying insulin resistance in black youth: a cross sectional analysis of the 1986 Jamaica birth cohort
(Peer reviewed; Journal article, 2010-12-07)Background While the International Diabetes Federation (IDF) has ethnic specific waist circumference (WC) cut-points for the metabolic syndrome for Asian populations it is not known whether the cut-points for black populations ... -
Arachnoid cysts do not contain cerebrospinal fluid: A comparative chemical analysis of arachnoid cyst fluid and cerebrospinal fluid in adults
(Peer reviewed; Journal article, 2010-06-10)Background Arachnoid cyst (AC) fluid has not previously been compared with cerebrospinal fluid (CSF) from the same patient. ACs are commonly referred to as containing "CSF-like fluid". The objective of this study was to ... -
Arc expression and protein-protein interactions in a mouse model of Alzheimer’s disease. Exercise- and novelty-induced changes in Arc, BDNF, and PS1 expression and Arc PS1 interaction in APP/PS1 and WT mice
(Master thesis, 2017)The overarching goal of this project was to help elucidate how some of the molecular mechanisms behind memory and learning differ between healthy brains and those with neurodegenerative diseases, specifically by studying ... -
Arc interacts with the integral endoplasmic reticulum protein, calnexin
(Peer reviewed; Journal article, 2017-09-20)Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum ... -
Arc is a flexible modular protein capable of reversible self-oligomerization
(Peer reviewed; Journal article, 2015)The immediate early gene product Arc (activity-regulated cytoskeleton-associated protein) is posited as a master regulator of long-term synaptic plasticity and memory. However, the physicochemical and structural properties ... -
The Arc of synaptic memory
(Peer reviewed; Journal article, 2010)The immediate early gene Arc is emerging as a versatile, Wnely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storage in the nervous system. ... -
Arc protein-protein interactions in long-term potentiation in the rat dentate gyrus in vivo
(Master thesis, 2014-06-02)Synaptic plasticity is the ability of neuronal synapses to change in strength over time, and is considered to be a foundation for learning and memory. Long-term potentiation (LTP) is a widely studied form of synaptic ...