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Inhibition of cyclooxygenases attenuates diet-induced obesity and compensatory increased glucose-stimulated insulin secretion in C57BL/6J mice
(Master thesis, 2013-05-15)Obesity is considered a state of low-grade inflammation, and this inflammation is strongly related to development of systematic insulin resistance. Hyperglycemia develops during insulin resistance as insulin-stimulated ... -
Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes
(Journal article; Peer reviewed, 2023)Melanoma has the highest propensity of all cancers to metastasize to the brain with a large percentage of late-stage patients developing metastases in the central nervous system (CNS). It is well known that metastasis ... -
Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis
(Peer reviewed; Journal article, 2019-04-10)Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across ... -
Inhibition of NF-κB signaling alters acute myelogenous leukemia cell transcriptomics
(Journal article; Peer reviewed, 2020)Acute myelogenous leukemia (AML) is an aggressive hematological malignancy. The pathophysiology of the disease depends on cytogenetic abnormalities, gene mutations, aberrant gene expressions, and altered epigenetic regulation. ... -
Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach
(Journal article; Peer reviewed, 2021)Heat shock protein (Hsp) synthesis is upregulated in a wide range of cancers to provide the appropriate environment for tumor progression. The Hsp110 and Hsp70 families have been associated to cancer cell survival and ... -
Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole—In Vitro and In Vivo Investigations
(Journal article; Peer reviewed, 2020)Serotonin (5-HT) is a hormone and neurotransmitter that modulates neural activity as well as a wide range of other physiological processes including cardiovascular function, bowel motility, and platelet aggregation. 5-HT ... -
Inhibition of tunneling nanotube (TNT) formation and Human T-cell leukemia virus type 1 (HTLV-1) transmission by cytarabine
(Peer reviewed; Journal article, 2018-07-24)The human T-cell leukemia virus type 1 (HTLV-1) is highly dependent on cell-to-cell interaction for transmission and productive infection. Cell-to-cell interactions through the virological synapse, bioflm-like structures ... -
Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone
(Journal article; Peer reviewed, 2022)Vesicular monoamine transporter 2 (VMAT2) is responsible for packing monoamine neurotransmitters into synaptic vesicles for storage and subsequent neurotransmission. VMAT2 inhibitors are approved for symptomatic treatment ... -
Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABA_A receptors of A17 amacrine cells in the rat retina
(Journal article; Peer reviewed, 2022)Amacrine cells constitute a large and heterogeneous group of inhibitory interneurons in the retina. The A17 amacrine plays an important role for visual signalling in the rod pathway microcircuit of the mammalian retina. ... -
Initial healthcare and coping preferences are associated with outcome 1 year after whiplash trauma: A multicentre 1-year follow-up study
(Peer reviewed; Journal article, 2015-03-20)Objective: Individuals exposed to whiplash collisions have to cope with the stressful event as well as early physical symptoms. As in other chronic pain conditions, coping has been associated with outcome after whiplash. ... -
Initial rhythm control with cryoballoon ablation vs drug therapy: Impact on quality of life and symptoms
(Journal article; Peer reviewed, 2021)Background Cryoballoon ablation (CBA) as a first-line rhythm control strategy is superior to antiarrhythmic drugs (AADs) for preventing atrial fibrillation (AF) recurrence; the impact of first-line CBA on quality of life ... -
Initiation of anti-osteoporotic drugs in high-risk female patients starting glucocorticoid treatment: a population study in Norway
(Journal article; Peer reviewed, 2020)Summary: Glucocorticoid use is a risk factor for osteoporosis and fractures. We studied whether women initiating glucocorticoid treatment also started anti-osteoporotic treatment, according to clinical guidelines. Women ... -
Injuries in Khartoum State, Sudan. Magnitude, consequences and healthcare utilization: a community-based survey
(Doctoral thesis, 2014-06-13)Background: Injuries contribute significantly to the global burden of disease accounting for 5.1 million deaths annually. Fatal injuries are the tip of the iceberg and many more who survive an injury suffer the consequences ... -
Injuries in Khartoum state, the Sudan: a household survey of incidence and risk factors
(Peer reviewed; Journal article, 2014)Low- and middle-income countries have a higher burden of fatal and non-fatal injuries. The lack of evidence-based information hampers efforts for injury prevention. The aim of this study was to calculate non-fatal injury ... -
Injury death certificates without specification of the circumstances leading to the fatal injury - the Norwegian Cause of Death Registry 2005-2014
(Peer reviewed; Journal article, 2018-12-24)Background: For injury deaths, the underlying cause of death is defined as the circumstances leading to the injury. When this information is missing, the ICD-10 code X59 (Exposure to unspecified factor) is used. Lack of ... -
Injury morbidity in an urban and a rural area in Tanzania: an epidemiological survey
(Peer reviewed; Journal article, 2005-01-28)Background: Injuries are becoming a major health problem in developing countries. Few population based studies have been carried out in African countries. We examined the pattern of nonfatal injuries and associated risk ... -
Innate Lymphoid Cells in Skin Homeostasis and Malignancy
(Journal article; Peer reviewed, 2021)Innate lymphoid cells (ILCs) are mostly tissue resident lymphocytes that are preferentially enriched in barrier tissues such as the skin. Although they lack the expression of somatically rearranged antigen receptors present ... -
Innføring av barneovervåkningsenhet ved en stor barne og ungdomsklinikk
(Journal article; Peer reviewed, 2022)BAKGRUNN Ved norske sykehus har det vært et mål å opprette barneovervåkningsenheter. Vi ønsket å beskrive pasientpopulasjonen ved en slik enhet samt undersøke om behovet for innleggelser i intensivavdeling endret seg etter ... -
Innføring av elektronisk ressursstyring - En ressurs for avdelingssykepleiere på post? En kvalitativ studie av avdelingssykepleiere, bemanningskoordinatorer og en sentral lederskikkelse sin opplevelse av innføringen av elektronisk ressursstyring i et helseforetak i Norge
(Master thesis, 2011-02)Background: This paper is a study of the experiences from different groups of employees due to the introduction of a new electronic resource control system for leading members of Helse Stavanger HF. Purpose: This paper ...