Browsing Department of Clinical Science by Title
Now showing items 1596-1615 of 2343
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Oral microbiota in autoimmune polyendocrine syndrome type 1
(Peer reviewed; Journal article, 2018)Background: Autoimmune polyendocrine syndrome type-1 (APS-1) is a rare, childhood onset disease caused by mutations in the Autoimmune Regulator gene. The phenotypic expression is highly variable and includes disease ... -
An organellar Nα-acetyltransferase, Naa60, acetylates cytosolic n termini of transmembrane proteins and maintains golgi integrity
(Peer reviewed; Journal article, 2015-02-26)N-terminal acetylation is a major and vital protein modification catalyzed by N-terminal acetyltransferases (NATs). NatF, or Nα-acetyltransferase 60 (Naa60), was recently identified as a NAT in multicellular eukaryotes. ... -
Organizational structures influencing timely recognition and acknowledgment of end-of-life in hospitals – A qualitative study of nurses' and doctors’ experiences
(Journal article; Peer reviewed, 2023)Purpose Healthcare personnel's timely recognition and acknowledgment of end-of-life (EOL) is fundamental for reducing futile treatment, enabling informed decisions regarding the last days or weeks of life, and focusing ... -
Our genes, our selves: hereditary breast cancer and biological citizenship in Norway
(Peer reviewed; Journal article, 2017-03)In this paper we explore the rise of ‘the breast cancer gene’ as a field of medical, cultural and personal knowledge. We address its significance in the Norwegian public health care system in relation to so-called biological ... -
Outcome after rewarming from accidental hypothermia by use of extracorporeal circulation
(Peer reviewed; Journal article, 2017)Background: Accidental hypothermia with arrested circulation remains a condition associated with high mortality. In our institution, extracorporeal circulation (ECC) rewarming has been the cornerstone in treating such ... -
Outcomes following PDA surgery in extremely preterm born subjects. Focusing on left vocal cord paralysis and associated short- and long-tem outcomes
(Doctoral thesis, 2022-06-14)Background: Extremely preterm born (EPB) infants are at risk of a range of complications, among them a patent ductus arteriosus (PDA). If a conservative approach does not reduce the cardiopulmonary compromise imposed by ... -
Outdoor air pollution and hormone-assessed pubertal development in children: Results from the GINIplus and LISA birth cohorts
(Journal article; Peer reviewed, 2021)Background Air pollution is hypothesized to affect pubertal development. However, the few studies on this topic yielded overall mixed results. These studies did not consider important pollutants like ozone, and none of ... -
Overcoming addition of phosphoethanolamine to lipid A mediated colistin resistance in Acinetobacter baumannii clinical isolates with colistin–sulbactam combination therapy
(Journal article; Peer reviewed, 2022)Overcoming colistin-resistant Acinetobacter baumannii (CoR-AB) has become a major concern due to the lack of effective antibiotics. This study aimed to explore the prevalence of CoR-AB clinical isolates in Thailand, their ... -
Overweight and obesity in children: a study of weight-related anthropometric variables in childhood
(Doctoral thesis, 2015-11-13) -
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
(Journal article; Peer reviewed, 2020)Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates ... -
Oxygen concentration in inhaled gas and nitric oxide concentration in exhaled gas. Is nitric oxide concentration in exhaled gas a useful marker for exposure to hyperoxia?
(Doctoral thesis, 2014-04-10)Background: Exposure to partial pressures of oxygen (PO2) higher than 50 kPa may result in toxic effects on the lungs with reduced vital capacity, maximal expiratory flow rates and diffusion capacity. The risk of developing ... -
p53 protein biosignatures in acute myeloid leukemia
(Doctoral thesis, 2006-03-10)p53 is a tumor suppressor protein often regarded as the guardian of the genome. It is a highly connected protein involved in many signaling processes in the cell. The inactivation of p53 through genetic mutations in TP53 ... -
p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy
(Journal article; Peer reviewed, 2021)p53 protein isoform expression has been found to correlate with prognosis and chemotherapy response in acute myeloid leukemia (AML). We aimed to investigate how p53 protein isoforms are modulated during epigenetic ... -
Pain and pain tolerance in whiplash-associated disorders:A population-based study
(Peer reviewed; Journal article, 2015)Background: Pain is a cardinal symptom in individuals with whiplash-associated disorders (WAD). We aimed to compare pain characteristics between individuals with WAD and individuals reporting chronic pain from other causes, ... -
Paradoxical sinus deceleration during dobutamine stress echocardiography: case series and review of the literature
(Journal article; Peer reviewed, 2022)Background: Dobutamine stress echocardiography is an established diagnostic modality for assessing myocardial ischaemia in patients with known or suspected coronary artery disease. Dobutamine infusion causes dose-dependent ... -
Parent psychological wellbeing in a single-family room versus an open bay neonatal intensive care unit
(Peer reviewed; Journal article, 2019-11-05)Background Studies of parents’ psychological well-being in single-family rooms in neonatal intensive care units have shown conflicting results. Aims To compare emotional distress in the form of depression, anxiety, stress ... -
Parental anxiety related to referral of childhood heart murmur; an observational/interventional study
(Peer reviewed; Journal article, 2015-11-21)Background: Detection of a heart murmur in healthy children is common, but may generate anxiety among parents. Many parents believe a heart murmur is a sign of heart disease, although the majority of heart murmurs are ... -
Parental involvement in decision-making about their child's health care at the hospital
(Peer reviewed; Journal article, 2018-07-30)Aim: To explore parents’ experiences on parental involvement in decision‐making about their child’s health care at the hospital and to identify how health professionals can improve parental involvement. Design: An explorative ... -
Parental smoking and risk of childhood-onset type 1 diabetes
(Peer reviewed; Journal article, 2018-11)Background: A few prospective studies suggest an association between maternal smoking during pregnancy and lower risk of type 1 diabetes. However, the role of unmeasured confounding and misclassification remains unclear. ... -
Parents’ Attitudes toward Clinical Genetic Testing for Autism Spectrum Disorder—Data from a Norwegian Sample
(Peer reviewed; Journal article, 2017-05-18)Clinical genetic testing (CGT) of children with autism spectrum disorder (ASD) may have positive and negative effects. Knowledge about parents’ attitudes is needed to ensure good involvement of caregivers, which is crucial ...