Browsing Department of Clinical Science by Title

Now showing items 1262-1281 of 2340

    • Kinetics of 2 different high-sensitive troponins during targeted temperature management in out-of-hospital cardiac arrest patients with acute myocardial infarction: a post hoc sub-study of a randomised clinical trial 

      Larsen, Alf Inge; Grejs, Anders Morten; Vistisen, Simon Tilma; Strand, Kristian; Skadberg, Øyvind; Jeppesen, Anni Nørgaard; Duez, Christophe H. V.; Kirkegaard, Hans; Søreide, Eldar (Journal article; Peer reviewed, 2022)
      Introduction Short term hypothermia has been suggested to have cardio protective properties in acute myocardial infarction (AMI) by reducing infarct size as assessed by troponins. There are limited data on the kinetics ...

    • Kjernereseptorar og endokrinforstyrrande stoff: Ligandaktiveringsstudiar av human Pregnan X Reseptor (hPXR) og human Østrogen Reseptor alfa (hERalfa) med luciferase transfeksjonsassay 

      Sørland, Gunn-Therese Lund (Master thesis, 2008-05-28)
      Samandrag Pregnan X Reseptor (PXR) er ein kjernereseptor som ved aktivering kan indusere transkripsjon av CYP3A4 enzym. Desse enzyma er involvert i metabolisme av mange sambindingar som til dømes legemiddel. PXR vert ...

    • Kosthold og fysisk aktivitet, har det en påvirkning på overvekt og fedme hos barn og unge? - En analyse av innsamlede data, og et systematisk litteratur søk 

      Halvorsen, Lenn Stian (Master thesis, 2012-05-15)
      Background: The prevalence of overweight and obesity has increased during the last decades in many countries, and current prevalence data are alarming and give reason for serious health concerns in the future. However, our ...

    • KRAS-G12C mutation in one real-life and three population-based Nordic cohorts of metastatic colorectal cancer 

      Osterlund, Emerik; Ristimäki, Ari; Kytölä, Soili; Kuopio, Teijo; Heervä, Eetu; Muhonen, Timo; Halonen, Päivi; Kallio, Raija; Soveri, Leena-Maija; Sundström, Jari; Keinänen, Mauri; Ålgars, Annika; Ristamäki, Raija; Sorbye, Halfdan; Pfeiffer, Per; Nunes, Luís; Salminen, Tapio; Lamminmäki, Annamarja; Mäkinen, Markus J.; Sjöblom, Tobias; Isoniemi, Helena; Glimelius, Bengt; Osterlund, Pia (Journal article; Peer reviewed, 2022-02-16)
      Background: KRAS mutations, present in over 40% of metastatic colorectal cancer (mCRC), are negative predictive factors for anti-EGFR therapy. Mutations in KRAS-G12C have a cysteine residue for which drugs have been ...

    • Krill oil attenuates left ventricular dilatation after myocardial infarction in rats 

      Fosshaug, Linn Elisabeth; Berge, Rolf Kristian; Beitnes, Jan Otto; Berge, Kjetil; Vik, Hogne; Aukrust, Pål; Gullestad, Lars; Vinge, Leif Erik; Øie, Erik (Peer reviewed; Journal article, 2011-12-29)
      Background: In the western world, heart failure (HF) is one of the most important causes of cardiovascular mortality. Supplement with n-3 polyunsaturated fatty acids (PUFA) has been shown to improve cardiac function in HF ...

    • Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study 

      Berge, Rolf Kristian; Ramsvik, Marie Sannes; Bohov, Pavol; Svardal, Asbjørn; Nordrehaug, Jan Erik; Rostrup, Espen; Bruheim, Inge; Bjørndal, Bodil (Peer reviewed; Journal article, 2015-12-15)
      Background: Lipid abnormalities, enhanced inflammation and oxidative stress seem to represent a vicious circle in atherogenesis, and therapeutic options directed against these processes seems like a reasonable approach in ...

    • Kronisk transplantat-mot-vertsykdom 

      Rørvik, Synne Dragesund; Abrahamsen, Ingerid Weum; Myhre, Anders Eivind; Vo, Camilla Dao; Meling, Eva Ødegaard; Bruserud, Øystein; Gedde-Dahl, Tobias; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2023)
      Kronisk transplantat-mot-vert-sykdom er en senkomplikasjon etter allogen stamcelletransplantasjon, og medfører kronisk inflammasjon og fibrose i forskjellige organer på grunn av feil regulering av donors immunceller. ...

    • Kvalitet av generika 

      Ashraf, Attyah (Master thesis, 2014-05-20)
      Bakgrunn: Forskning har vist at det er betydelig skepsis i befolkningen til generiske legemidler, selv om disse per definisjon er bioekvivalente. Dette har også blitt vist i flere bioekvivalensstudier. Det rapporteres ...

    • The kynurenine pathway in cognition, dementia, and aging 

      Solvang, Stein-Erik Hafstad (Doctoral thesis, 2021-06-16)
      Background: Experimental studies implicate the kynurenine pathway in cognitive function, dementia, aging, and longevity. Comparatively, clinical studies are few and most lack comprehensive targeted metabolomic profiling ...

    • The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics 

      Tillmann, Sandra; Awwad, Hussain M.; MacPherson, Chad W.; Happ, Denise F.; Treccani, Giulia; Geisel, Juergen; Tompkins, Thomas A.; Ueland, Per Magne; Wegener, Gregers; Obeid, Rima (Journal article; Peer reviewed, 2021)
      Scope Probiotics exert immunomodulatory effects and may influence tryptophan metabolism in the host. Deficiency of nutrients related to C1 metabolism might stimulate inflammation by enhancing the kynurenine pathway. This ...

    • Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging 

      Solvang, Stein-Erik Hafstad; Hodge, Allison; Watne, Leiv; Cabral-Marques, Otavio; Nordrehaug, Jan Erik; Giles, Graham G.; Dugué, Pierre-Antoine; Nygård, Ottar Kjell; Ueland, Per Magne; McCann, Adrian; Idland, Ane-Victoria; Midttun, Øivind; Ulvik, Arve; Halaas, Nathalie Bodd; Tell, Grethe S.; Melvær, Giil Lasse (Journal article; Peer reviewed, 2022)
      The kynurenine pathway is implicated in aging, longevity, and immune regulation, but longitudinal studies and assessment of the cerebrospinal fluid (CSF) are lacking. We investigated tryptophan (Trp) and downstream kynurenine ...

    • Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia 

      Solvang, Stein-Erik Hafstad; Nordrehaug, Jan Erik; Aarsland, Dag; Lange, Johannes; Ueland, Per Magne; McCann, Adrian; Midttun, Øivind; Tell, Grethe S.; Melvær, Giil Lasse (Journal article; Peer reviewed, 2019)
      Introduction: Circulating tryptophan (Trp) and its downstream metabolites, the kynurenines, are potentially neuroactive. Consequently, they could be associated with neuropsychiatric symptoms and cognitive prognosis in ...

    • Label-free quantitative proteomic analysis of the oral bacteria Fusobacterium nucleatum and Porphyromonas gingivalis to identify protein features relevant in biofilm formation 

      Mohammed, Marwan; Pettersen, Veronika K.; Nerland, Audun Helge; Wiker, Harald Gotten; Bakken, Vidar (Journal article; Peer reviewed, 2021)
      Background The opportunistic pathogens Fusobacterium nucleatum and Porphyromonas gingivalis are Gram-negative bacteria associated with oral biofilm and periodontal disease. This study investigated interactions between F. ...

    • Laboratory contamination in airway microbiome studies 

      Drengenes, Christine; Wiker, Harald G; Kalananthan, Tharmini; Nordeide, Eli; Eagan, Tomas Mikal; Nielsen, Rune (Peer reviewed; Journal article, 2019-08-14)
      Background The low bacterial load in samples acquired from the lungs, have made studies on the airway microbiome vulnerable to contamination from bacterial DNA introduced during sampling and laboratory processing. We have ...

    • Laparoskopisk gastrisk bypassoperasjon versus livsstilsbehandling av unge med sykelig overvekt 

      Hjelmesæth, Jøran; Hertel, Jens Kristoffer; Holt, Ane Hjetland; Benestad, Beate; Seeberg, Lars Thomas; Lindberg, Morten; Halvorsen, Erling; Juliusson, Petur Benedikt; Sandbu, Rune; Lekhal, Samira (Journal article; Peer reviewed, 2020)
      BAKGRUNN Kunnskapsgrunnlaget om effekten av og komplikasjoner ved vektreduserende kirurgi hos ungdom er mangelfullt. Hovedformålet med 4XL-studien er å avklare om laparoskopisk Roux-en-Y gastrisk bypassoperasjon (LGBP) ...

    • A large community outbreak of waterborne giardiasis- delayed detection in a non-endemic urban area 

      Nygård, Karin; Schimmer, Barbara; Søbstad, Øystein; Walde, Anna; Tveit, Ingvar; Langeland, Nina; Hausken, Trygve; Aavitsland, Preben (BMC Public Health 6(141), Peer reviewed; Journal article, 2006-05-25)
      Background: Giardia is not endemic in Norway, and more than 90% of reported cases acquire the infection abroad. In late October 2004, an increase in laboratory confirmed cases of giardiasis was reported in the city of ...

    • Large-scale genomics unveil polygenic architecture of human cortical surface area 

      Chen, Chi-Hua; Peng, Qian; Schork, Andrew J.; Lo, Min-Tzu; Fan, Chun-Chieh; Wang, Yunpeng; Desikan, Rahul S.; Bettella, Franscesco; Hagler, Donald J.; Westlye, Lars Tjelta; Kremen, William S.; Jernigan, Terry L.; Le Hellard, Stephanie; Steen, Vidar Martin; Espeseth, Thomas; Huentelman, Matt; Håberg, Asta; Agartz, Ingrid; Djurovic, Srdjan; Andreassen, Ole Andreas; Schork, Nicholas; Dale, Anders (Peer reviewed; Journal article, 2015-07-20)
      Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence ...

    • Laryngeal response patterns during mechanically assisted cough in Amyotrophic Lateral Sclerosis 

      Andersen, Tiina Maarit (Doctoral thesis, 2018-06-21)
      Background: Patients with amyotrophic lateral sclerosis (ALS) are treated with mechanical cough assist devices using the technique of mechanical insufflationexsufflation (MI-E) in order to improve cough and enhance clearance ...

    • Laryngeal tube use in out-of-hospital cardiac arrest by paramedics in Norway 

      Sunde, Geir Arne; Brattebø, Guttorm; Ødegården, Terje; Kjernlie, Dag Frode; Rødne, Emma Sjøgren; Heltne, Jon-Kenneth (Peer reviewed; Journal article, 2012-12-18)
      Background: Although there are numerous supraglottic airway alternatives to endotracheal intubation, it remains unclear which airway technique is optimal for use in prehospital cardiac arrests. We evaluated the use of the ...

    • Late-onset sepsis in very preterm infants in Norway in 2009-2018: A population-based study 

      Huncikova, Zuzana; Vatne, Anlaug; Stensvold, Hans Jørgen; Lang, Astri Maria; Støen, Ragnhild; Brigtsen, Anne Karin; Salvesen, Bodil; Øymar, Knut Asbjørn Alexander; Rønnestad, Arild Erland; Klingenberg, Claus Andreas (Journal article; Peer reviewed, 2023)
      Objective: To evaluate epidemiology and outcomes among very preterm infants (<32 weeks’ gestation) with culture-positive and culture-negative late-onset sepsis (LOS). Design: Cohort study using a nationwide, population-based ...