Blar i Department of Clinical Science på tittel
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Influence of obesity on left ventricular adaptation, grading and outcome in aortic valve stenosis
(Doctoral thesis, 2014-09-29)Background/Aim: Obesity is associated with hemodynamic changes characterized by volume overload adding to the progressive pressure overload induced by aortic valve stenosis (AS). This thesis investigated whether concomitant ... -
Influence of p53 isoform expression on survival in high-grade serous ovarian cancers
(Peer reviewed; Journal article, 2019-03-27)High-grade serous ovarian carcinoma (HGSOC) is characterised by alterations in the p53 pathway. The expression levels of p53 isoforms have been shown to be associated with patient survival in several cancers. This study ... -
The influence of region of interest width in fetal 2D-speckle tracking echocardiography late in pregnancy
(Journal article; Peer reviewed, 2021)Speckle tracking echocardiography is a promising method for assessment of myocardial function in fetal and neonatal hearts, but further studies are necessary to validate and optimize the settings for use in fetal cardiology. ... -
The influence of socio-demographic and clinical factors on sick leave and return to work after open-heart surgery: a nationwide registry-based cohort study
(Journal article; Peer reviewed, 2023)Aims: To estimate sick leave (SL) duration after first-time elective open-heart surgery and identify factors contributing to increased SL. Methods and results: A retrospective nationwide cohort study combined data from ... -
Influenza Vaccination Strategies: Comparing Inactivated and Live Attenuated Influenza Vaccines
(Peer reviewed; Journal article, 2015-04-24)Influenza is a major respiratory pathogen causing annual outbreaks and occasional pandemics. Influenza vaccination is the major method of prophylaxis. Currently annual influenza vaccination is recommended for groups at ... -
Influenza virus and related activity in the palatine tonsils after live attenuated influenza vaccination
(Master thesis, 2015-10-30)Influenza is a common infection in humans, with annual outbreaks. It can cause severe disease and have great socioeconomic impact. Children are more susceptible to infection than adults, especially when they have a naïve ... -
Inhibiting notch activity in breast cancer stem cells by glucose functionalized nanoparticles carrying γ-secretase inhibitors
(Peer reviewed; Journal article, 2016-05)Cancer stem cells (CSCs) are a challenge in cancer treatment due to their therapy resistance. We demonstrated that enhanced Notch signaling in breast cancer promotes self-renewal of CSCs that display high glycolytic activity ... -
Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis
(Peer reviewed; Journal article, 2016-08-11)Rheumatoid arthritis is characterised by synovial inflammation and proliferation of fibroblast-like synoviocytes. The induction of apoptosis has long been proposed as a target for proliferative autoimmune diseases, and has ... -
Inhibition of NF-κB signaling alters acute myelogenous leukemia cell transcriptomics
(Journal article; Peer reviewed, 2020)Acute myelogenous leukemia (AML) is an aggressive hematological malignancy. The pathophysiology of the disease depends on cytogenetic abnormalities, gene mutations, aberrant gene expressions, and altered epigenetic regulation. ... -
Inhibition of tunneling nanotube (TNT) formation and Human T-cell leukemia virus type 1 (HTLV-1) transmission by cytarabine
(Peer reviewed; Journal article, 2018-07-24)The human T-cell leukemia virus type 1 (HTLV-1) is highly dependent on cell-to-cell interaction for transmission and productive infection. Cell-to-cell interactions through the virological synapse, bioflm-like structures ... -
Initial healthcare and coping preferences are associated with outcome 1 year after whiplash trauma: A multicentre 1-year follow-up study
(Peer reviewed; Journal article, 2015-03-20)Objective: Individuals exposed to whiplash collisions have to cope with the stressful event as well as early physical symptoms. As in other chronic pain conditions, coping has been associated with outcome after whiplash. ... -
Initial rhythm control with cryoballoon ablation vs drug therapy: Impact on quality of life and symptoms
(Journal article; Peer reviewed, 2021)Background Cryoballoon ablation (CBA) as a first-line rhythm control strategy is superior to antiarrhythmic drugs (AADs) for preventing atrial fibrillation (AF) recurrence; the impact of first-line CBA on quality of life ... -
Insall proximal realignment with/without tibial tubercle osteotomy for recurrent patellar instability yields acceptable medium- to long-term results but risk of osteoarthritis progression is considerable
(Journal article; Peer reviewed, 2022-07-06)Purpose: The purpose of this study was to evaluate clinical and radiological results in patients operated for recurrent patellar instability with a surgical approach consisting of Insall proximal realignment with/without ... -
Insights into Sex and Gender Differences in Brain and Psychopathologies Using Big Data
(Journal article; Peer reviewed, 2023)The societal implication of sex and gender (SG) differences in brain are profound, as they influence brain development, behavior, and importantly, the presentation, prevalence, and therapeutic response to diseases. ... -
Intake of baked cod fillet resulted in lower serum cholesterol and higher long chain n-3 PUFA concentrations in serum and tissues in hypercholesterolemic obese Zucker fa/fa rats
(Peer reviewed; Journal article, 2018-06-28)Increasing evidence indicates that lean fish consumption may benefit cardiovascular health. High cholesterol and low n-3 PUFA concentrations in serum are associated with an increased risk of coronary heart disease; therefore, ... -
Intake of different types of seafood and meat and risk of type 2 diabetes in women: a prospective study supported by a dietary intervention in mice
(Journal article; Peer reviewed, 2024)Detailed knowledge regarding the associations between intake of different types of seafood and meat and the risk of type 2 diabetes (T2D), and insight into possible mechanisms are warranted. In this study we aimed to ... -
Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance
(Journal article; Peer reviewed, 2022)Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer deaths in women. Here we present an integrated multi-omic analysis of 643 cervical squamous cell carcinomas (CSCC, the most common histological ... -
Integrated analysis of robust sex-biased gene signatures in human brain
(Journal article; Peer reviewed, 2023)Background: Sexual dimorphism is highly prominent in mammals with many physiological and behavioral differences between male and female form of the species. Accordingly, the fundamental social and cultural stratification ... -
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells
(Peer reviewed; Journal article, 2010-07-09)Background Several observations suggest that immunological events early after chemotherapy, possibly during the period of severe treatment-induced cytopenia, are important for antileukemic immune reactivity in acute myeloid ...