Browsing Department of Clinical Science by Title
Now showing items 1509-1528 of 2374
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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Clinical trials, medical treatment and pathomechanisms
(Doctoral thesis, 2024-05-02)Myalgisk encefalomyelitt/kronisk utmattelsessyndrom (ME/CFS) er en underprioritert sykdom som rammer 0,2-0,8 % av befolkningen, med ukjent etiologi, høy symptombelastning, ingen biomarkør, og ingen godkjent effektiv ... -
MYC-induced miR-203b-3p and miR-203a-3p control Bcl-xL expression and paclitaxel sensitivity in tumor cells
(Peer reviewed; Journal article, 2018)Taxanes are chemotherapeutic agents used in the treatment of solid tumors, particularly of breast, ovarian, and lung origin. However, patients show divergent therapy responses, and the molecular determinants of taxane ... -
The mycobiome in COPD: Descriptive and longitudinal analysis, and participation in research bronchoscopy studies
(Doctoral thesis, 2021-06-25)Background: Chronic obstructive pulmonary disease (COPD) is a high-prevalent lung disease with high mortality rates. The COPD pathogenesis is only partly understood, and we do not know why some risk factor exposed subjects ... -
Myocardial Connective Tissue Growth Factor (CCN2/CTGF) Attenuates Left Ventricular Remodeling after Myocardial Infarction
(Peer reviewed; Journal article, 2012-12-20)Aims: Myocardial CCN2/CTGF is induced in heart failure of various etiologies. However, its role in the pathophysiology of left ventricular (LV) remodeling after myocardial infarction (MI) remains unresolved. The current ... -
Myocardial energy metabolism and ultrastructure with polarizing and depolarizing cardioplegia in a porcine model
(Peer reviewed; Journal article, 2017-03-02)OBJECTIVES: This study investigated whether the novel St. Thomas’ Hospital polarizing cardioplegic solution (STH-POL) with esmolol/adenosine/magnesium offers improved myocardial protection by reducing demands for high-energy ... -
Myocardial function after polarizing versus depolarizing cardiac arrest with blood cardioplegia in a porcine model of cardiopulmonary bypass
(Peer reviewed; Journal article, 2016)OBJECTIVES Potassium-based depolarizing St Thomas' Hospital cardioplegic solution No 2 administered as intermittent, oxygenated blood is considered as a gold standard for myocardial protection during cardiac surgery. ... -
Myocardial function in aortic stenosis - insights from radial multilayer Doppler strain
(Peer reviewed; Journal article, 2015-02-19)Background Left ventricular (LV) radial tissue Doppler imaging (TDI) strain increases gradually from the subepicardial to the subendocardial layer in healthy individuals. A speckle tracking echocardiography study suggested ... -
Myocardial function including estimates of myocardial work in young adults born very preterm or with extremely low birthweight - a cohort study
(Journal article; Peer reviewed, 2023)Background Preterm birth and low birthweight have been associated with increased risk of heart failure and cardiovascular disease in young adulthood. However, results from clinical studies of myocardial function are not ... -
Myocardial injury in a 41-year-old male treated with methylphenidate: a case report
(Peer reviewed; Journal article, 2014-07-29)Background: Elevated cardiac troponin levels are consistent with the diagnosis of an acute coronary syndrome, but may also represent adverse drug reactions. Psychostimulating drugs raise both blood pressure and heart rate, ... -
Myocardial ischemia in non-obstructive coronary artery disease : Associations with coronary artery disease morphology and left ventricular hypertrophy
(Doctoral thesis, 2020-09-22)Background: The underlying mechanisms causing myocardial ischemia in non-obstructive coronary artery disease (CAD) are incompletely understood. We tested whether the total coronary artery plaque burden, coronary tortuosity ... -
Myocardial Work in Middle-Aged Adults with Overweight and Obesity: Associations with Sex and Central Arterial Stiffness
(Journal article; Peer reviewed, 2023)We explored global myocardial work index (GWI), a novel measure of myocardial function that integrates left ventricular (LV) hemodynamic load, in relation to sex and increased body mass index (BMI). We used data from 467 ... -
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
(Journal article; Peer reviewed, 2023)Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global scale has remained obscure. Using genome-wide CRISPR knockout screens in human cells, we reveal a strong genetic dependency between ... -
N-terminal pro-B-type natriuretic peptide as a prognostic indicator for 30-day mortality following out-of-hospital cardiac arrest: A prospective observational study
(Journal article; Peer reviewed, 2020-08-24)Background Early risk stratification applying cardiac biomarkers may prove useful in sudden cardiac arrest patients. We investigated the prognostic utility of early-on levels of high sensitivity cardiac troponin-T (hs-cTnT), ... -
N-terminal pro-B-type natriuretic peptide for prediction of ventricular arrhythmias: Data from the SMASH study
(Journal article; Peer reviewed, 2023)Background Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations predict heart failure (HF) and mortality, but whether NT-proBNP predicts ventricular arrhythmias (VA) is not clear. Hypothesis We ... -
N-terminal pro-B-type natriuretic peptide level at longterm follow-up after atrial fibrillation ablation: A marker of reverse atrial remodeling and successful ablation
(Peer reviewed; Journal article, 2011-10-13)Aims: We investigated the relationship between arrhythmia burden, left atrial volume (LAV) and N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) at baseline and after long-term follow-up of atrial fibrillation (AF) ... -
A national intercalated medical student research program–student perceptions, satisfaction, and factors associated with pursuing a PhD
(Journal article; Peer reviewed, 2022)Background: To counteract a decreasing number of physician-scientists, a national intercalated Medical Student Research Programme (MSRP) was launched in Norway in 2002. We aimed to assess whether the students’ favourable ... -
Nationwide audit and feedback on implementation of antibiotic stewardship programmes in Norwegian hospitals
(Journal article; Peer reviewed, 2021)Background Implementation of antibiotic stewardship programmes (ASPs) in hospitals is challenging and there is a knowledge gap on how to pursue this process efficiently. Objectives To evaluate whether audit and feedback ... -
A nationwide genomic study of clinical Klebsiella pneumoniae in Norway 2001–15: introduction and spread of ESBLs facilitated by clonal groups CG15 and CG307
(Journal article; Peer reviewed, 2022)Objectives To use the nationwide Norwegian surveillance programme on resistant microbes in humans (NORM) to address longitudinal changes in the population structure of Klebsiella pneumoniae isolates from 2001–15, focusing ... -
A nationwide school fruit and vegetable policy and childhood and adolescent overweight: A quasi-natural experimental study
(Journal article; Peer reviewed, 2022)Background School free fruit and vegetable (FFV) policies are used to promote healthy dietary habits and tackle obesity; however, our understanding of their effects on weight outcomes is limited. We assess the effect of ... -
The natural history of 21-hydroxylase autoantibodies in autoimmune Addison’s disease
(Journal article; Peer reviewed, 2021)Background: The most common cause of primary adrenal failure (Addison’s disease) in the Western world is autoimmunity characterized by autoantibodies against the steroidogenic enzyme 21-hydroxylase (CYP21A2, 21OH). Detection ...