Blar i Department of Clinical Science på tittel
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Daily intake of protein from cod residual material lowers serum concentrations of nonesterified fatty acids in overweight healthy adults: A randomized double-blind pilot study
(Peer reviewed; Journal article, 2018-06-05)Improved process technologies have allowed fishing vessels to utilize residuals from cod fillet production (head, backbone, skin, cuttings, and entrails) and convert this to high-quality protein powders for human consumption. ... -
Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: Clinical results from a randomised phase-2 study (NordCML006)
(Peer reviewed; Journal article, 2014-09-13)We randomised 46 newly diagnosed patients with chronic myeloid leukaemia (median age 56) to receive dasatinib 100 mg QD or imatinib 400 mg QD and report outcome as an intention-to-treat analysis with 36 months follow-up. ... -
Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies
(Journal article; Peer reviewed, 2021-01-20)Introduction: Inflammation is a normal physiological process that increases to harmful levels in preeclampsia. It affects the interaction between maternal immune cells and fetal trophoblasts at both sites of the maternal-fetal ... -
Deciphering rare imprinting disorders within the Beckwith-Wiedemann spectrum
(Doctoral thesis, 2022-10-28)Beckwith-Wiedemann syndrom (BWS) er den hyppigste og mest komplekse tilstanden blant imprintingssykdommene. Avhandlingen presenterer tre ulike BWS spektrum familier, hvor vi utvider forståelsen av arvemønsteret ved BWS, ... -
Decision support system and outcome prediction in a cohort of patients with necrotizing soft-tissue infections
(Journal article; Peer reviewed, 2022)Introduction: Necrotizing Soft Tissue Infections (NSTI) are severe infections with high mortality affecting a heterogeneous patient population. There is a need for a clinical decision support system which predicts outcomes ... -
Decision-making preceding transcatheter aortic valve implantation in frail older adults : Vulnerable autonomy, novel frailty scoring and clinical outcomes important to treatment strategy. A mixed method study
(Doctoral thesis, 2020-04-24)Introduction: Transcatheter aortic valve implantation (TAVI), also known as transcatheter aortic valve replacement (TAVR), is a new technique for treating severe, symptomatic aortic stenosis. The mean age for TAVI patients ... -
Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells
(Journal article; Peer reviewed, 2020)Schizophrenia (SCZ) is a severe mental disorder with a high heritability. Although its pathophysiology is mainly unknown, dysregulated immune activation and inflammation have recently emerged as possible candidates in the ... -
Decreased T-cell response against latent cytomegalovirus infection does not correlate with anti-IFN autoantibodies in patients with APECED
(Journal article; Peer reviewed, 2024)Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inborn error of immunity affecting both multiple endocrine organs and susceptibility to candidiasis, each with an autoimmune basis. Recently, ... -
Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays
(Peer reviewed; Journal article, 2018-05-23)Recent advances in optical technologies such as multi-photon microscopy and optogenetics have revolutionized our ability to record and manipulate neuronal activity. Combining optical techniques with electrical recordings ... -
Deep exploration of a CDKN1C mutation causing a mixture of Beckwith-Wiedemann and IMAGe syndromes revealed a novel transcript associated with developmental delay
(Journal article; Peer reviewed, 2022)Background: Loss-of-function mutations in CDKN1C cause overgrowth, that is, Beckwith-Wiedemann syndrome (BWS), while gain-of-function variants in the gene’s PCNA binding motif cause a growth-restricted condition called ... -
Deep phenotyping of pubertal development in Norwegian children: the Bergen Growth Study 2
(Journal article; Peer reviewed, 2023)Background The Bergen Growth Study 2 (BGS2) aims to characterise somatic and endocrine changes in healthy Norwegian children using a novel methodology. Subjects and methods A cross-sectional sample of 1285 children ... -
Definition of novel cell envelope associated proteins in Triton X-114 extracts of Mycobacterium tuberculosis H37Rv
(Peer reviewed; Journal article, 2010-04-29)Background Membrane- and membrane-associated proteins are important for the pathogenicity of bacteria. We have analysed the content of these proteins in virulent Mycobacterium tuberculosis H37Rv using Triton X-114 ... -
Delineating cellular and molecular mechanisms of toxicity of an extract of khat (Catha edulis Forsk.) in leukemia and normal peripheral blood cells
(Doctoral thesis, 2010-05-07)Plants have been used in treatment and prevention of diseases for thousands of years. In modern medicine there is a trend towards isolation and identification of bioactive molecules, whereas plant preparations continue to ... -
Delirium after Aortic Valve Therapy. A Prospective Cohort Study of Octogenarian Patients following Surgical Aortic Valve Replacement and Transcatheter Aortic Valve Implantation.
(Doctoral thesis, 2016-08-25)Introduction: Untreated and symptomatic aortic stenosis (AS) is associated with high mortality. Surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI) are two treatment options for ... -
Delirium as a Predictor of Physical and Cognitive Function in Individuals Aged 80 and Older After Transcatheter Aortic Valve Implantation or Surgical Aortic Valve Replacement
(Peer reviewed; Journal article, 2016-06)Objectives: To determine how development of delirium after surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI) could predict activity of daily living (ADL) and instrumental ADLs (IADL) ... -
The delirium screening tool 4AT in routine clinical practice: prediction of mortality, sensitivity and specificity
(Journal article; Peer reviewed, 2021)Purpose Delirium is common and associated with poor outcomes, partly due to underdetection. We investigated if the delirium screening tool 4 A’s test (4AT) score predicts 1 year mortality and explored the sensitivity and ... -
Delirium screening with 4AT in patients aged 65 years and older admitted to the Emergency Department with suspected sepsis: a prospective cohort study
(Journal article; Peer reviewed, 2021)Purpose We aimed to study the use of The 4 ‘A’s test (4AT), a rapid delirium screening tool, performed upon Emergency Department (ED) admission, and to characterize older patients admitted to the ED with and without sepsis ... -
Dementia Researchers’ Inside Views on Research Networks and Alignment With Public Research Funding: A Qualitative Study
(Journal article; Peer reviewed, 2023)This study presents the dementia researchers views of research networks, and how the networks fit into their pursuit of research objectives and dementia research funding. We conducted 10 semi-structured interviews with 10 ... -
Demultiplexing Stress Responses and Compensatory Mechanisms in the Pancreatic Islet
(Doctoral thesis, 2024-06-21)Et nøkkelelement i utviklingen av diabetes er den manglende evnen hos de insulinproduserende β-cellene til å møte et stigende behov for insulin, skapt av dysfunksjonelle eller døde β-celler. Det er mange faktorer som ... -
Dendritic cell populations in patients with self-reported food hypersensitivity
(Peer reviewed; Journal article, 2011-05)Self-reported hypersensitivity to food is a common condition and many of these patients have indications of intestinal immune activation. Dendritic cells (DCs) are recognized as the most potent antigen-presenting cells ...