Browsing Department of Clinical Science by Title

Now showing items 1398-1417 of 2397

    • Machine learning approaches in microbiome research: challenges and best practices 

      Papoutsoglou, Georgios; Tarazona, Sonia; Lopes, Marta B.; Klammsteiner, Thomas; Ibrahimi, Eliana; Eckenberger, Julia; Novielli, Pierfrancesco; Tonda, Alberto; Simeon, Andrea; Shigdel, Rajesh; Béreux, Stéphane; Vitali, Giacomo; Tangaro, Sabina; Lahti, Leo; Temko, Andriy; Claesson, Marcus J.; Berland, Magali (Journal article; Peer reviewed, 2023)
      Microbiome data predictive analysis within a machine learning (ML) workflow presents numerous domain-specific challenges involving preprocessing, feature selection, predictive modeling, performance estimation, model ...

    • Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction 

      Woolley, Rebecca J.; Ceelen, Daan; Ouwerkerk, Wouter; Tromp, Jasper; Figarska, Sylwia M.; Anker, Stefan D.; Dickstein, Kenneth; Filippatos, Gerasimos; Zannad, Faiez; Marco, Metra; Ng, Leong L.; Samani, Nilesh J.; van Veldhuisen, Dirk J; Lang, Chim C.; Lam, Carolyn S.P.; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims The lack of effective therapies for patients with heart failure with preserved ejection fraction (HFpEF) is often ascribed to the heterogeneity of patients with HFpEF. We aimed to identify distinct pathophysiologic ...

    • Magnetic Resonance Imaging and Computed Tomography for the Noninvasive Assessment of Arterial Aging: A Review by the VascAgeNet COST Action 

      Bianchini, Elisabetta; Lønnebakken, Mai Tone; Wohlfahrt, Peter; Piskin, Senol; Terentes-Printzios, Dimitrios; Alastruey, Jordi; Guala, Andrea (Journal article; Peer reviewed, 2023)
      Magnetic resonance imaging and computed tomography allow the characterization of arterial state and function with high confidence and thus play a key role in the understanding of arterial aging and its translation into the ...

    • Maintained survival outcome after reducing lymphadenectomy rates and optimizing adjuvant treatment in endometrial cancer 

      Forsse, David Erik; Berg, Hege Fredriksen; Bozickovic, Olivera; Engerud, Hilde Renate; Halle, Mari Kyllesø; Høivik, Erling Andre; Woie, Kathrine; Werner, Henrica Maria Johanna; Haldorsen, Ingfrid S.; Trovik, Jone; Krakstad, Camilla (Journal article; Peer reviewed, 2020)
      Objective: Main controversies in endometrial cancer treatment include the role of lymphadenectomy and optimal adjuvant treatment. We assessed clinical outcome in a population-based endometrial cancer cohort in relation to ...

    • Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery 

      Trøseid, Marius; Hov, Johannes Espolin Roksund; Nestvold, Torunn Kristin; Thoresen, Hanne; Berge, Rolf Kristian; Svardal, Asbjørn M.; Lappegård, Knut Tore (Journal article; Peer reviewed, 2016)
      Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary phosphatidylcholine and carnitine. An alternative pathway of ...

    • Making wise decisions for completion thyroidectomies 

      Brun, Vegard Heimly; Brauckhoff, Katrin (Journal article; Peer reviewed, 2022)

    • Malaria prevalence among patients with acute undifferentiated fever in secondary hospitals in India 

      Haanshuus, Christel Gill; Vivek, Rosario; Xena, Deepika; Chandy, Sara; Mathai, Dilip; Manoharan, Anand; Langeland, Nina; Blomberg, Bjørn; Mørch, Kristine (Conference poster, 2014-09-22)

    • Malaria prevalence and performance of diagnostic tests among patients hospitalized with acute undifferentiated fever in Zanzibar 

      Onken, Annette; Haanshuus, Christel Gill; Miraji, Mohammed Khamis; Marijani, Msafiri; Kibwana, Kibwana Omar; Abeid, Khamis Ali; Mørch, Kristine; Reimers, Marianne; Langeland, Nina; Müller, Fredrik; Jenum, Pål; Blomberg, Bjørn (Journal article; Peer reviewed, 2022-02-19)
      Background: Control efforts in Zanzibar reduced the burden of malaria substantially from 2000 to 2015, but re-emergence of falciparum malaria has been observed lately. This study evaluated the prevalence of malaria and ...

    • Management and interpretation of heterogeneous observational data: Using insulin-like growth factor-I data from the NordiNet® International Outcome Study 

      Blankenstein, Oliver; Pedersen, Birgitte Tønnes; Schlumpf, Michael; Andreasen, Arne Haahr; Juliusson, Petur Benedikt (Peer reviewed; Journal article, 2014-12-09)
      Objective. The NordiNet® International Outcome Study (IOS), a large-scale, non-interventional, multi-centre, real-world study of Norditropin® treatment, registers insulin-like growth factor-I (IGF-I) values, as measured ...

    • Managing Contamination and Diverse Bacterial Loads in 16S rRNA Deep Sequencing of Clinical Samples: Implications of the Law of Small Numbers 

      Dyrhovden, Ruben; Rippin, Martin; Øvrebø, Kjell Kåre; Nygaard, Randi Monsen; Ulvestad, Elling; Kommedal, Øyvind (Journal article; Peer reviewed, 2021)
      In this article, we investigate patterns of microbial DNA contamination in targeted 16S rRNA amplicon sequencing (16S deep sequencing) and demonstrate how this can be used to filter background bacterial DNA in diagnostic ...

    • Mapping the expression of an ANK3 isoform associated with bipolar disorder in the human brain 

      Holmgren, Asbjørn; Hansson, Lars; Bjerkaas-Kjeldal, Kristine; Impellizzeri, Agata Antonia Rita; Gilfillan, Gregor; Djurovic, Srdjan; Hughes, Timothy (Journal article; Peer reviewed, 2022)
      The gene ankyrin-3 (ANK3) has been consistently associated with bipolar disorder (BD) in several genome-wide association studies (GWAS). The exact molecular mechanisms underlying this genetic association remain unknown. ...

    • Mapping the human genetic architecture of COVID-19 

      Niemi, Mari E.K.; Karjalainen, Juha; Liao, Rachel G.; Neale, Benjamin M.; Daly, Mark; Ganna, Andrea; Pathak, Gita A.; Andrews, Shea J.; Kanai, Masahiro; Veerapen, Kumar; Fernandez-Cadenas, Israel; Schulte, Eva C.; Striano, Pasquale; Afset, Jan Egil; Solligård, Erik; Damås, Jan Kristian; Risnes, Kari; Bettini, Laura Rachele; Gustad, Lise Tuset; Holter, Jan Cato; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Folseraas, Trine; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Grimsrud, Marit Mæhle; Vadla, May Sissel; Myhre, Ronny; Kildal, Anders Benjamin; Hoff, Dag Arne Lihaug; Muller, Karl Erik; Heggelund, Lars; Bergan, Jonas; Skogen, Vegard (Journal article; Peer reviewed, 2021)
      The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity ...

    • Markedsføring av naturmidler- en vurdering 

      Tønnesen, Maria Høyland (Master thesis, 2008-06-02)
      Hensikten med oppgaven var å undersøke og sammenligne markedsføringen av naturmidler i kommunikasjonskanalene apotek, helsekostforretninger, Internett, ukeblad og magasiner. I løpet av ti uker ble det samlet inn annonser, ...

    • Markers of disease activity in COPD: an 8-year mortality study in the ECLIPSE cohort 

      Celli, Bartolome; Locantore, Nicholas; Yates, Julie C.; Bakke, Per S.; Calverley, Peter M.A.; Crim, Courtney; Coxson, Harvey O.; Lomas, David A.; MacNee, William; Miller, Bruce E.; Mullerova, Hana; Rennard, Stephen I.; Silverman, Edwin K.; Wouters, Emiel F.; Tal-Singer, Ruth; Agusti, Alvar; Vestbo, Jørgen (Journal article; Peer reviewed, 2021)
      Rationale There are no validated measures of disease activity in COPD. Since “active” disease is expected to have worse outcomes (e.g. mortality), we explored potential markers of disease activity in patients enrolled in ...

    • Markers of nephropathy in young Fabry disease patients; role of kidney biopsies and functional measurements 

      Tøndel, Camilla (Doctoral thesis, 2013-04-05)
      Backgound: Fabry disease is an X-linked disease affecting glycosphingolipid metabolism due to deficiency of the lysosomal enzyme α-galactosidase. The natural course of the disease is related to progressive accumulation of ...

    • Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery 

      Kovac, Nina; Grymyr, Lisa Marie Dale; Gerdts, Eva; Nadirpour, Saied; Nedrebø, Bjørn Gunnar; Hjertaas, Johannes Just; Matre, Knut; Cramariuc, Dana (Journal article; Peer reviewed, 2022)
      Background: Aortic valve sclerosis (AVS), mitral valve sclerosis (MVS), remodeling of major arteries, and increased pericardial fat are associated with subclinical atherosclerosis. We assessed these markers of atherosclerosis ...

    • Masked hypertension in obesity: Potential predictors and arterial damage 

      Kenny, Isabel E.; Saeed, Sahrai; Gerdts, Eva; Midtbø, Helga Bergljot; Halland, Hilde; Lønnebakken, Mai Tone (Peer reviewed; Journal article, 2017-02)
      Background: Masked hypertension (MHT), defined as normal office blood pressure (BP) but high ambulatory BP, has been associated with increased cardiovascular risk. Although MHT has been associated with obesity, there is ...

    • Maternal allergen immunisation to prevent sensitisation in offspring: Th2-polarising adjuvants are more efficient than a Th1-polarising adjuvant in mice 

      Ellertsen, Linda K.; Nygaard, Unni C.; Melkild, Ingrid; Løvik, Martinus (Peer reviewed; Journal article, 2010-03-01)
      Background Allergy has been an increasing problem in several parts of the world. Prenatal exposure to allergen and microbial components may affect the development of allergies in childhood, as indicated by epidemiological ...

    • Maternal and child gluten intake and association with type 1 diabetes: The Norwegian Mother and Child Cohort Study 

      Lund-Blix, Nicolai Andre; Tapia, German; Mårild, Karl Staffan; Brantsæter, Anne Lise; Njølstad, Pål Rasmus; Joner, Geir; Skrivarhaug, Torild; Størdal, Ketil; Stene, Lars Christian Mørch (Journal article; Peer reviewed, 2020)
      Background The relationship between maternal gluten intake in pregnancy, offspring intake in childhood, and offspring risk of type 1 diabetes has not been examined jointly in any studies. Our aim was to study the relationship ...

    • Maternal and iatrogenic factors influencing the duration of labour 

      Østborg, Tilde Broch (Doctoral thesis, 2023-06-22)
      Bakgrunn: Forlengede fødselsforløp er den fremste grunnen til keisersnitt og operative vaginale forløsninger på verdensbasis. Imidlertid er definisjonen av normal fødselsprogresjon og varighet gjenstand for en pågående ...