Browsing Department of Clinical Science by Title
Now showing items 1646-1665 of 2318
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Personal Cancer Genome Reporter: Variant interpretation report for precision oncology
(Peer reviewed; Journal article, 2018-05)Individual tumor genomes pose a major challenge for clinical interpretation due to their unique sets of acquired mutations. There is a general scarcity of tools that can (i) systematically interrogate cancer genomes in the ... -
Pharmacokinetics, Safety, and Tolerability of Imipenem/Cilastatin/Relebactam in Children with Confirmed or Suspected Gram-Negative Bacterial Infections: A Phase 1b, Open-Label, Single-Dose Clinical Trial
(Journal article; Peer reviewed, 2023)Imipenem/cilastatin/relebactam is approved for the treatment of serious gram-negative bacterial infections in adults. This study assessed the pharmacokinetics (PK), safety, and tolerability of a single dose of imipenem/c ... -
Pharmacokinetics, transcriptional changes and oxidative stress in pink shrimp (Pandalus montagui) exposed to teflubenzuron
(Master thesis, 2017-06-28)In the recent years, infestation with salmon lice has become a major problem in salmonid farms, and has resulted in great economic losses and reduced welfare for farmed salmonids. To enhance the salmon lice combat, there ... -
Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III
(Peer reviewed; Journal article, 2019)Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with ... -
A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer
(Journal article; Peer reviewed, 2023)Metastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflammatory ... -
Phase II study of everolimus and temozolomide as first-line treatment in metastatic high-grade gastroenteropancreatic neuroendocrine neoplasms
(Journal article; Peer reviewed, 2023)Background The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy ... -
Phenazine 5,10-dioxide analogues as drugs against acute myeloid leukaemia. -Preclinical documentation for lead selection
(Master thesis, 2018-06-29)Background: Acute Myeloid Leukaemia (AML) is a form of cancer that is associated with low survival rates, and where the current treatment is impaired by low tolerance and severe side-effects. Thus, novel treatments are ... -
Phenotypic Characterization by Mass Cytometry of the Microenvironment in Ovarian Cancer and Impact of Tumor Dissociation Methods
(Journal article; Peer reviewed, 2021)Improved molecular dissection of the tumor microenvironment (TME) holds promise for treating high-grade serous ovarian cancer (HGSOC), a gynecological malignancy with high mortality. Reliable disease-related biomarkers are ... -
Phenotypic diversity of human adipose tissue-resident NK cells in obesity
(Journal article; Peer reviewed, 2023-02-22)Natural killer (NK) cells have emerged as key mediators of obesity-related adipose tissue inflammation. However, the phenotype of NK cell subsets residing in human adipose tissue are poorly defined, preventing a detailed ... -
The pholcodine Case. Cough Medicines, IgE-Sensitization, and Anaphylaxis: A Devious Connection
(Peer reviewed; Journal article, 2012-07-15)The Scandinavian data on pholcodine (PHO) strongly indicates that there is a biological chain from PHO exposure through IgE-sensitization to IgE-mediated anaphylaxis to neuromuscular blocking agents (NMBA). PHO is probably ... -
A Phospholipid-Protein Complex from Antarctic Krill Reduced Plasma Homocysteine Levels and Increased Plasma Trimethylamine-N-Oxide (TMAO) and Carnitine Levels in Male Wistar Rats
(Peer reviewed; Journal article, 2015-09-08)Seafood is assumed to be beneficial for cardiovascular health, mainly based on plasma lipid lowering and anti-inflammatory effects of n-3 polyunsaturated fatty acids. However, other plasma risk factors linked to cardiovascular ... -
A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats
(Peer reviewed; Journal article, 2015-07-16)Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have ... -
Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults
(Peer reviewed; Journal article, 2014-05-17)Background: Herring roe is an underutilized source of n-3 polyunsaturated fatty acids (PUFAs) for human consumption with high phospholipid (PL) content. Studies have shown that PL may improve bioavailability of n-3 PUFAs. ... -
Physical activity and exercise capacity in survivors of preterm birth : A population-based cohort study of long-term consequences of prematurity
(Doctoral thesis, 2022-05-19)Background: Physical activity (PA) is an important mediator of health. Extremely preterm (EP) (<28 weeks’ gestation) and extremely low birth weight (ELBW) (<1000 g) subjects are at increased risk of long-term sequelae that ... -
Physical activity and risk of all-cause mortality in patients with stable angina pectoris: Effect modification by β-blocker treatment
(Journal article; Peer reviewed, 2022)Background Physical activity (PA) influences sympathetic stimulation, platelet activation as well as vascular function, and has been associated with improved health outcomes in patients with coronary heart disease. β-blocker ... -
Physical activity, exercise and cardiac troponins: Clinical implications
(Peer reviewed; Journal article, 2019)Cardiac troponins constitute essential components of the cardiac contractile apparatus and are released into the bloodstream following cardiomyocyte injury. Because of their cardiac specificity, cardiac troponin I or T are ... -
Physical and cognitive performance after blood donation : A clinical study to investigate donor safety in walking blood banks
(Doctoral thesis, 2023-06-13)De siste 20 årene har fullblod til pasienter i blødningssjokk blitt re-lansert som foretrukket behandling. I vandrende blodbanker blir blodet oppbevart i original forpakningen inntil behovet oppstår. Konseptet har logistiske ... -
Physiotherapy improves symptoms of exercise-induced laryngeal obstruction in young elite athletes: A case series
(Peer reviewed; Journal article, 2019)Objective: A constricted, upper chest breathing pattern and postural dealignments habitually accompany exercise-induced laryngeal obstruction (EILO), but there are few effective treatments for athletes presenting with EILO. ... -
Phytochemical Observations on European Mistletoe (Viscum album L.)
(Master thesis, 2009-06-12)Non-polar constituents were extracted from Viscum album with hexane, by Soxhlet extraction. The extract was analysed by gas chromatography - mass spectrometry, and the following fatty acids, methyl esters and triterpenes ... -
Phytochemicals as a Source of Novel Drugs Against Prostate Cancer - Preparation of Animal Experiments and Isolation and Identification of Flavonoid Glycosides from Abies pindrow
(Master thesis, 2012-05-21)Introduction: Plants and herbs have been utilized for centuries by traditional medicinal systems (e.g. TCM, Ayurveda) to alleviate minor illnesses and major diseases. In recent decades, interest in traditional medicine has ...