Browsing Department of Clinical Science by Title
Now showing items 1726-1745 of 2318
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Preclinical models and molecular biomarkers. Tools to improve treatment in endometrial carcinoma
(Doctoral thesis, 2018-11-30)Background: Endometrial carcinoma is the fourth most common cancer in European women, and incidence is increasing. No major improvements in treatment or survival have been achieved over the last decades, and an individualized ... -
Preclinical molecular imaging in oncology – From chemical synthesis to clinical translatable applications
(Doctoral thesis, 2021-06-25)Background: Molecular imaging (MI) is fundamental in clinical settings for diagnosis, treatment selection, intraoperative guidance and treatment efficacy evaluation. This field has progressed rapidly in recent years, driven ... -
Preconceptional smoking alters spermatozoal miRNAs of murine fathers and affects offspring’s body weight
(Journal article; Peer reviewed, 2021)Background Active smoking has been reported among 7% of teenagers worldwide, with ages ranging from 13 to 15 years. An epidemiological study suggested that preconceptional paternal smoking is associated with adolescent ... -
Preconditioning serum levels of endothelial cell-derived molecules and the risk of posttransplant complications in patients treated with allogeneic stem cell transplantation.
(Peer reviewed; Journal article, 2014-10-08)Endothelial cells are involved in the pathogenesis of acute graft-versus-host disease (GVHD) after allogeneic stem cell transplantation. These cells express several molecules that can be detected as biologically active ... -
Predicted signal peptides, and the role of the N-terminal tail, at the monoamine G-protein coupled receptors 5-HT2c and α2c
(Doctoral thesis, 2015-03-06)Background: G-protein coupled receptors (GPCRs) have seven transmembrane helices and are situated in the cell membrane, where they transduce signals from specific ligands to the interior of the cell. The first step in the ... -
Predicting physical activity in a national cohort of children born extremely preterm
(Journal article; Peer reviewed, 2020)Predicting physical activity in a national cohort of children born extremely preterm. Objectives: To compare physical activity among school-aged children born extremely preterm or with extremely low birthweight (EP/ELBW) ... -
Predicting preeclampsia from a history of preterm birth
(Peer reviewed; Journal article, 2017-07-24)Objective: To assess whether women with a history of preterm birth, independent on the presence of prelabour rupture of the membranes (PROM) and growth deviation of the newborn, are more likely to develop preeclampsia with ... -
Prediction of adverse perinatal outcome of small-forgestational- age pregnancy using size centiles and conditional growth centiles
(Peer reviewed; Journal article, 2016-08)Objective: To test whether adding conditional growth centiles to size centiles of estimated fetal weight (EFW) improves prediction of adverse perinatal outcome in pregnancies with or at risk of having a small-for-gestational-age ... -
Prediction of indirect interactions in proteins
(Peer reviewed; Journal article, 2006-03-22)Background: Both direct and indirect interactions determine molecular recognition of ligands by proteins. Indirect interactions can be defined as effects on recognition controlled from distant sites in the proteins, e.g. ... -
Prediction of type 1 diabetes at birth: Cord blood metabolites vs genetic risk score in the Norwegian mother, father, and child cohort
(Journal article; Peer reviewed, 2021)Background and aim: Genetic markers are established as predictive of type 1 diabetes, but unknown early life environment is believed to be involved. Umbilical cord blood may reflect perinatal metabolism and exposures. We ... -
Predictive and Prognostic Impact of TP53 Mutations and MDM2 Promoter Genotype in Primary Breast Cancer Patients Treated with Epirubicin or Paclitaxel
(Peer reviewed; Journal article, 2011-04-27)Background: TP53 mutations have been associated with resistance to anthracyclines but not to taxanes in breast cancer patients. The MDM2 promoter single nucleotide polymorphism (SNP) T309G increases MDM2 activity and may ... -
Predictive and prognostic markers in localized colon cancer : with emphasis on the biomarkers maspin, mismatch repair deficiency, CDX2, tumor grade, PD-L1, and tumor-infiltrating lymphocytes.
(Doctoral thesis, 2022-06-23)Colon cancer is one of the most common cancers worldwide. Predicting disease outcomes is challenging. Around 15-20% of patients will experience disease relapse. At the same time, a substantial fraction of patients will ... -
Predictors of adherence and the role of primary non-adherence in antihormonal treatment of breast cancer
(Journal article; Peer reviewed, 2022-12-02)Background: Antihormonal treatment for hormone receptor (HR) positive breast cancer has highly beneficial effects on both recurrence rates and survival. We investigate adherence and persistence in this group of ... -
Predictors of diagnostic yield in bronchoscopy: a retrospective cohort study comparing different combinations of sampling techniques
(Peer reviewed; Journal article, 2008-01-26)Background: The reported diagnostic yield from bronchoscopies in patients with lung cancer varies greatly. The optimal combination of sampling techniques has not been finally established. The objectives of this study were ... -
Predictors of exacerbations in chronic obstructive pulmonary disease - results from the Bergen COPD Cohort Study
(Peer reviewed; Journal article, 2014-10-03)Background: COPD exacerbations accelerate disease progression. Aims To examine if COPD characteristics and systemic inflammatory markers predict the risk for acute COPD exacerbation (AECOPD) frequency and duration. Methods: ... -
Predictors of health-related quality of life changes after lifestyle intervention in persons at risk of type 2 diabetes mellitus
(Peer reviewed; Journal article, 2014-11)Purpose: To assess health-related quality of life (HRQOL) of subjects at risk of type 2 diabetes undergoing lifestyle intervention, and predictors for improved HRQOL. Methods: The Finnish Diabetes Risk Score was used by ... -
Predictors of long time survival after lung cancer surgery. A retrospective cohort study.
(Peer reviewed; Journal article, 2008-10-27)Background: There have been few reports regarding long time survival after lung cancer surgery. The influence of age and pulmonary function on long time survival is still not fully discovered. Some reports suggest that ... -
Predictors of long-term symptom burden and quality of life in patients hospitalised with chest pain: a prospective observational study
(Journal article; Peer reviewed, 2022)Objective: To describe the magnitude and predictors of symptom burden (SB) and quality of life (QoL) 3 months after hospital admission for acute chest pain. Design: Prospective observational study. Setting: Single ... -
Predictors of underweight, overweight and obesity, and effect of treatment of obesity in early childhood
(Doctoral thesis, 2020-11-17)Abstract Background: The prevalence of overweight (OW) and obesity (OB) has escalated throughout the world over the last decades, both in children and adults. Childhood OB is a major risk factor for adult OB and the ... -
Predominance of PVL-negative community-associated methicillin-resistant Staphylococcus aureus sequence type 8 in newly diagnosed HIV-infected adults, Tanzania
(Journal article; Peer reviewed, 2021)Difficult-to-treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are of concern in people living with HIV infection as they are more vulnerable to infection. We aimed to identify molecular ...