Browsing Department of Clinical Science by Title
Now showing items 1851-1870 of 2395
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Prognostic significance of S100A4 expression in stage II and III colorectal cancer: results from a population-based series and a randomized phase III study on adjuvant chemotherapy
(Peer reviewed; Journal article, 2016-08)Current clinical algorithms are unable to precisely predict which colorectal cancer patients would benefit from adjuvant chemotherapy, and there is a need for novel biomarkers to improve the selection of patients. The ... -
Prognostic utility of vitamin D in acute coronary syndrome patients in coastal Norway
(Peer reviewed; Journal article, 2015)BACKGROUND: An inverse relationship between cardiovascular risk and levels of vitamin D and omega-3 index may exist. OBJECTIVES: To evaluate the prognostic utility of serum 25-hydroxyvitamin D [25(OH)D] in 871 patients ... -
Prognostic value of baseline functional status measures and geriatric screening in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy – The randomized NORDIC9-study
(Journal article; Peer reviewed, 2023)Introduction Appropriate patient selection based on functional status is crucial when considering older adults for palliative chemotherapy. This pre-planned analysis of the randomized NORDIC9-study explored the prognostic ... -
Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy
(Peer reviewed; Journal article, 2012-01-25)Background: Today’s clinical diagnostic tools are insufficient for giving accurate prognosis to breast cancer patients. The aim of our study was to examine the tumor metabolic changes in patients with locally advanced ... -
The prognostic value of pre-treatment circulating biomarkers of systemic inflammation (CRP, dNLR, YKL-40, and IL-6) in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy—The Randomized NORDIC9-Study
(Journal article; Peer reviewed, 2022)Appropriate patient selection for palliative chemotherapy is crucial in patients with metastatic colorectal cancer (mCRC). We investigated the prognostic value of C-reactive protein (CRP), derived neutrophil-to-lymphocyte ... -
Prognostic value of the diversity of nuclear chromatin compartments in gynaecological carcinomas
(Journal article; Peer reviewed, 2020)Statistical texture analysis of cancer cell nuclei stained for DNA has recently been used to develop a pan-cancer prognostic marker of chromatin heterogeneity. In this study, we instead analysed chromatin organisation by ... -
The progression of acute myeloid leukemia from first diagnosis to chemoresistant relapse: A comparison of proteomic and phosphoproteomic profiles
(Journal article; Peer reviewed, 2020)Acute myeloid leukemia (AML) is an aggressive hematological malignancy. Nearly 50% of the patients who receive the most intensive treatment develop chemoresistant leukemia relapse. Although the leukemogenic events leading ... -
Progression of renal disease. Pathogenetic aspects and treatment options
(Doctoral thesis, 2012-02-17) -
Prolonged and persistent diarrhoea is not restricted to children with acute malnutrition: an observational study in Ethiopia
(Peer reviewed; Journal article, 2019)Objectives: To assess the prevalence of prolonged and persistent diarrhoea, to estimate their co‐occurrence with acute malnutrition and association with demographic and clinical factors. Methods: Case–control study where ... -
Prolonging the delivery of influenza virus vaccine improves the quantity and quality of the induced immune responses in mice
(Journal article; Peer reviewed, 2023)Introduction: Influenza vaccines play a vital role in protecting individuals from influenza virus infection and severe illness. However, current influenza vaccines have suboptimal efficacy, which is further reduced in cases ... -
A proposed method to investigate reliability throughout a questionnaire
(Peer reviewed; Journal article, 2011-10-05)Background: Questionnaires are used extensively in medical and health care research and depend on validity and reliability. However, participants may differ in interest and awareness throughout long questionnaires, which ... -
A prospective observational study on newborn resuscitation in a high-resource setting
(Doctoral thesis, 2022-10-28)Bakgrunn: Omkring åtte prosent av verdens nyfødte har behov for pustehjelp for å klare overgangen fra intra- til ekstrauterint liv. Nøyaktig forekomst er usikker og varierer antagelig mellom ulike settinger, men resuscitering ... -
A prospective study of pulmonary outcomes and chest computed tomography in the first year after COVID-19
(Journal article; Peer reviewed, 2023)COVID-19 primarily affects the respiratory system. We aimed to evaluate how pulmonary outcomes develop after COVID-19 by assessing participants from the first pandemic wave prospectively 3 and 12 months following hospital ... -
A prospective, active haemovigilance study with combined cohort analysis of 19 175 transfusions of platelet components prepared with amotosalen-UVA photochemical treatment
(Peer reviewed; Journal article, 2015-05-15)Background and Objectives: A photochemical treatment process (PCT) utilizing amotosalen and UVA light (INTERCEPT™ Blood System) has been developed for inactivation of viruses, bacteria, parasites and leucocytes that can ... -
Prospects and challenges in the development of universal influenza vaccines
(Journal article; Peer reviewed, 2020-07-06)Current influenza vaccines offer suboptimal protection and depend on annual reformulation and yearly administration. Vaccine technology has rapidly advanced during the last decade, facilitating development of next-generation ... -
Proteasome‐mediated regulation of GATA2 expression and androgen receptor transcription in benign prostate epithelial cells
(Journal article; Peer reviewed, 2022)GATA2 has been shown to be an important transcription factor together with androgen receptor (AR) in prostate cancer cells. Less is known about GATA2 in benign prostate epithelial cells. We have investigated if GATA2 ... -
Protected sampling is preferable in bronchoscopic studies of the airway microbiome
(Journal article; Peer reviewed, 2017)The aim was to evaluate susceptibility of oropharyngeal contamination with various bronchoscopic sampling techniques. 67 patients with obstructive lung disease and 58 control subjects underwent bronchoscopy with ... -
A protein extract from chicken reduces plasma homocysteine in rats
(Peer reviewed; Journal article, 2015-06-04)The present study aimed to evaluate effects of a water-soluble protein fraction of chicken (CP), with a low methionine/glycine ratio, on plasma homocysteine and metabolites related to homocysteine metabolism. Male Wistar ... -
Protein Post-Translational Modification Crosstalk in Acute Myeloid Leukemia Calls for Action
(Peer reviewed; Journal article, 2019)Background: Post-translational modification (PTM) crosstalk is a young research field. However, there is now evidence of the extraordinary characterization of the different proteoforms and their interactions in a biological ... -
Protein profiling reveals inter-individual protein homogeneity of arachnoid cyst fluid and high qualitative similarity to cerebrospinal fluid
(Peer reviewed; Journal article, 2011-05-20)Background: The mechanisms behind formation and filling of intracranial arachnoid cysts (AC) are poorly understood. The aim of this study was to evaluate AC fluid by proteomics to gain further knowledge about ACs. Two goals ...