Browsing Department of Clinical Science by Title

Now showing items 2018-2037 of 2318

    • Sex disparity in acute myeloid leukaemia with FLT3 internal tandem duplication mutations: implications for prognosis 

      Hellesøy, Monica; Engen, Caroline Benedicte Nitter; Grob, Tim; Löwenberg, Bob; Valk, Peter J. M.; Gjertsen, Bjørn T. (Journal article; Peer reviewed, 2021)
      Incidence, molecular presentation and outcome of acute myeloid leukaemia (AML) are influenced by sex, but little attention has been directed at untangling sex-related molecular and phenotypic differences between female and ...

    • Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability 

      Lagou, Vasiliki; Mägi, Reedik; Hottenga, Jouke- Jan; Grallert, Harald; Perry, John R. B.; Bouatia-Naji, Nabila; Marullo, Letizia; Rybin, Denis V.; Jansen, Rick; Min, JL; Dimas, AS; Ulrich, Anna; Zudina, Liudmila; Gådin, Jesper R.; Jiang, Longda; Faggian, Alessia; Bonnefond, Amélie; Fadista, Joao; Stathopoulou, Maria G.; Isaacs, Aaron; Willems, Sara M.; Navarro, Pau; Tanaka, Toshiko; Jackson, Anne U.; Montasser, May E.; O’Connell, Jeff R.; Bielak, Lawrence F.; Webster, Rebecca J.; Saxena, Richa; Stafford, Jeanette M.; Pourcain, Beate St; Timpson, Nicholas J.; Salo, Perttu; Shin, SY; Amin, Najaf; Smith, Albert V.; Li, G; Verweij, Niek; Goel, Anuj; Ford, Ian; Johnson, Paul C. D.; Johnson, Toby; Kapur, Karen; Thorleifsson, Gudmar; Strawbridge, Rona J.; Rasmussen-Torvik, Laura J.; Esko, Tõnu; Mihailov, E; Fall, Tove; Fraser, Ross M; Mahajan, Anubha; Kanoni, Stavroula; Giedraitis, Vilmantas; Kleber, Marcus E.; Silbernagel, Günther; Meyer, Julia; Müller-Nurasyid, Martina; Ganna, Andrea; Sarin, Antti-Pekka; Yengo, Loic; Shungin, D; Luan, Jian’an; Horikoshi, Momoko; An, Ping; Sanna, Serena; Boettcher, Yvonne; Rayner, Nigel W; Nolte, Ilja M.; Zemunik, Tatijana; Iperen, Erik van; Kovacs, Peter; Hastie, Nicholas D.; Wild, Sarah H.; McLachlan, Stela; Campbell, Susan; Polasek, Ozren; Carlson, Olga; Egan, Josephine; Kiess, Wieland; Willemsen, Gonneke; Kuusisto, Johanna; Laakso, Markku; Dimitriou, M; Hicks, Andrew A.; Rauramaa, Rainer; Bandinelli, Stefania; Thorand, Barbara; Liu, Yongmei; Miljkovic, Iva; Lind, Lars; Doney, Alex; Perola, Markus; Hingorani, Aroon; Kivimaki, Mika; Kumari, Meena; Bennett, Amanda J.; Groves, Christopher J.; Herder, Christian; Koistinen, Heikki A.; Kinnunen, Leena; Faire, Ulf de; Bakker, Stephan J. L.; Uusitupa, Matti; Palmer, Colin N. A.; Jukema, J. Wouter; Sattar, Naveed; Pouta, Anneli; Snieder, Harold; Boerwinkle, Eric; Pankow, James S.; Magnusson, Patrik K.; Krus, Ulrika; Scapoli, Chiara; de Geus, Eco J. C. N.; Blüher, Matthias; Wolffenbuttel, Bruce H. R.; Province, Michael A.; Abecasis, Goncalo R.; Meigs, James B.; Hovingh, G. Kees; Lindström, Jaana; Wilson, JF; Wright, Alan F.; Dedoussis, George; Bornstein, Stefan R.; Schwarz, Peter E. H.; Tönjes, Anke; Winkelmann, Bernhard R.; Boehm, Bernhard O.; März, Winfried; Metspalu, Andres; Price, Jackie F.; Deloukas, Panos; Körner, Antje; Lakka, Timo A.; Keinanen-Kiukaanniemi, Sirkka M.; Saaristo, Timo E.; Bergman, Richard N.; Tuomilehto, Jaakko; Wareham, Nick; Langenberg, Claudia; Männistö, Satu; Franks, Paul W; Hayward, Caroline; Vitart, Veronique; Kaprio, Jaakko; Visvikis-Siest, Sophie; Balkau, Beverley; Altshuler, D; Rudan, Igor; Stumvoll, Michael; Campbell, Harry; van Duijn, Cornelia M.; Gieger, Christian; Illig, Thomas; Ferrucci, Luigi; Pedersen, Nancy L.; Pramstaller, Peter P.; Boehnke, Michael; Frayling, TM; Shuldiner, Alan R.; Peyser, Patricia A.; Kardia, Sharon L. R.; Palmer, Lyle J.; Penninx, Brenda W.; Meneton, Pierre; Harris, Tamara B.; Navis, Gerjan; Harst, Pim van der; Smith, George Davey; Forouhi, Nita G.; Loos, Ruth J. F.; Salomaa, Veikko; Soranzo, Nicole; Boomsma, Dorret I.; Groop, L; Tuomi, Tiinamaija; Hofman, Albert; Munroe, Patricia B.; Gudnason, Vilmundur; Siscovick, David S.; Watkins, Hugh; Lecoeur, Cecile; Vollenweider, Peter; Franco-Cereceda, Anders; Eriksson, Per; Jarvelin, Marjo-Riitta; Stefansson, Kari; Hamsten, Anders; Nicholson, George; Karpe, Fredrik; Dermitzakis, Emmanouil T.; Lindgren, Cecilia M.; McCarthy, Mark I.; Froguel, Philippe; Kaakinen, Marika A.; Lyssenko, Valeriya; Watanabe, Richard M.; Ingelsson, Erik; Florez, Jose C.; Dupuis, Josée; Barroso, I; Morris, Andrew P.; Prokopenko, Inga (Journal article; Peer reviewed, 2021)
      Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in ...

    • Sex-related change in BMI of 15- to 16-year-old Norwegian girls in cross-sectional studies in 2002 and 2017 

      Bjertnæs, Asborg Sine Aanstad; Grundt, Jacob Holter; Juliusson, Petur Benedikt; Markestad, Trond Jacob; Strand, Tor A; Holten-Andersen, Mads Nikolaj (Peer reviewed; Journal article, 2019-11-12)
      Background: The prevalence of overweight and obesity (OWOB) has stabilized in some countries, but a portion of children with high body mass index (BMI) may have become heavier. This study aimed to describe the distributions ...

    • Sex-Specific Associations between Blood Pressure and Risk of Atrial Fibrillation Subtypes in the Tromsø Study 

      Espnes, Hilde; Ball, Jocasta; Løchen, Maja-Lisa; Wilsgaard, Tom; Njølstad, Inger; Mathiesen, Ellisiv B; Gerdts, Eva; Sharashova, Ekaterina (Journal article; Peer reviewed, 2021)
      The aim of this study was to explore sex-specific associations between systolic blood pressure (SBP), hypertension, and the risk of incident atrial fibrillation (AF) subtypes, including paroxysmal, persistent, and permanent ...

    • Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients 

      Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine V.; Steen, Nils Eiel; Andreassen, Ole A.; Steen, Vidar M.; Melle, Ingrid (Journal article; Peer reviewed, 2021)
      Background: Schizophrenia is a disorder with considerable heterogeneity in course and outcomes, which is in part related to the patients' sex. Studies report a link between serum lipids, body mass index (BMI), and therapeutic ...

    • Sex-Specific Limitations in Physical Health in Primary Adrenal Insufficiency 

      Didriksen, Nora Møller; Sævik, Åse Bjorvatn; Sortland, Linn Solveig; Øksnes, Marianne; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2021)
      Background: Patients with primary adrenal insufficiency (PAI) suffer reduced quality of life (QoL), but comparisons with large-scale normative data are scarce. The clinical characteristics associated with reduced QoL are ...

    • Sex-specific reference ranges of cerebroplacental and umbilicocerebral ratios: A longitudinal study 

      Acharya, Ganesh; Ebbing, Cathrine; Karlsen, Henriette Odland; Kiserud, Torvid; Rasmussen, Svein (Peer reviewed; Journal article, 2020)
      Objectives: Observational studies have shown that low cerebroplacental ratio (CPR) values predict an increased risk of adverse perinatal outcome. The inverse ratio, i.e. the umbilicocerebral ratio (UCR), has been suggested ...

    • Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study 

      Laupsa-Borge, Johnny; Grytten, Elise; Bohov, Pavol; Bjørndal, Bodil; Strand, Elin; SKORVE, JON; Nordrehaug, Jan Erik; Berge, Rolf Kristian; Rostrup, Espen; Mellgren, Gunnar; Dankel, Simon N; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)
      Background: Clinical studies on effects of marine-derived omega-3 (n-3) polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and the plant-derived omega-6 (n-6) PUFA ...

    • Sex-specific time trends in incident atrial fibrillation and the contribution of risk factors: the Tromsø Study 1994–2016 

      Sharashova, Ekaterina; Gerdts, Eva; Ball, Jocasta; Espnes, Hilde; Jacobsen, Bjarne K.; Kildal, Simon; Mathiesen, Ellisiv B.; Njølstad, Inger; Rosengren, Annika; Schirmer, Henrik; Wilsgaard, Tom; Løchen, Maja-Lisa (Journal article; Peer reviewed, 2023)
      Aims To explore sex-specific time trends in atrial fibrillation (AF) incidence and to estimate the impact of changes in risk factor levels using individual participant-level data from the population-based Tromsø Study ...

    • Sexual activity and functioning in women treated for gynaecological cancers 

      Sekse, Ragnhild Johanne Tveit; Hufthammer, Karl Ove; Vika, Margrethe Elin (Peer reviewed; Journal article, 2017-02)
      Aims and objectives. A description and comparison of sexual activity and function in relation to various gynaecological cancer diagnoses, treatment modalities, age groups, psychological distress and health-related quality ...

    • Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease 

      Weening, Eerde H.; Al-Mubarak, Ali A.; Dokter, Martin M.; Dickstein, Kenneth; Lang, Chim C.; Ng, Leong L.; Metra, Marco; van Veldhuisen, Dirk J.; Touw, Daan J.; de Boer, Rudolf A.; Gansevoort, Ron T.; Voors, Adriaan A.; Bakker, Stephan J. L.; van der Meer, Peter; Bomer, Nils (Journal article; Peer reviewed, 2023)
      Background Serum selenium levels have been associated with the incidence of heart failure (HF) and signs of the metabolic syndrome. In addition, notable differences have been reported between males and females in food ...

    • Sexual Inactivity During the Last 4 Weeks in Long-Term Cervical Cancer Survivors: Prevalence and Associated Factors 

      Dahl, Alv A; Bentzen, Anne Gry; Fosså, Sophie Dorothea; Hess, Siri Lothe; Steen, Rita; Vistad, Ingvild; Kiserud, Cecilie E. (Journal article; Peer reviewed, 2020)
      Background Most studies of cervical cancer (CC) survivors describe sexual inactivity in relation to treatment modalities, but few consider that inactivity varies with age and partner status. Aim The aim of this study ...

    • SGLT1 inhibition boon or bane for diabetes-associated cardiomyopathy 

      Kalra, Jaspreet; Mangali, Suresh Babu; Dasari, Deepika; Bhat, Audesh; Goyal, Srashti; Dhar, Indu; Sriram, Dharamrajan; Dhar, Arti (Peer reviewed; Journal article, 2020)
      Chronic hyperglycaemia is a peculiar feature of diabetes mellitus (DM). Sequential metabolic abnormalities accompanying glucotoxicity are some of its implications. Glucotoxicity most likely corresponds to the vascular ...

    • The SH3PXD2A-HTRA1 fusion transcript is extremely rare in Norwegian sporadic vestibular schwannoma patients 

      Taule-Sivertsen, Peter; Bruland, Ove; Håvik, Aril Løge; Bratland, Eirik; Lund-Johansen, Morten; Knappskog, Per Morten (Journal article; Peer reviewed, 2021)
      Introduction Vestibular schwannoma (VS) is a benign intracranial tumor in which the underlying genetics is largely uncertain, apart from mutations in the tumor suppressor gene NF2. Alternative tumorigenic mechanisms have ...

    • Shared etiology of type 1 diabetes and Hashimoto’s thyroiditis: a population-based twin study 

      Skov, Jakob; Kuja-Halkola, Ralf; Magnusson, Patrik K.E.; Gudbjörnsdottir, Soffia; Kämpe, Olle; Bensing, Sophie (Journal article; Peer reviewed, 2022)
      Objective Type 1 diabetes and Hashimoto’s thyroiditis frequently cluster in individuals and in families, indicating shared origins. The objective of this study was to investigate familial co-aggregation of these diseases ...

    • Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis 

      Woldeyohannes, Markos Tesfaye; Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Rahman, Zillur; Bahrami, Shahram; Lin, Aihua; Holen, Børge; Parker, Nadine; Cheng, Weiqiu; Rødevand, Linn; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Smeland, Olav Bjerkehagen; O’Connell, Kevin S.; Andreassen, Ole (Journal article; Peer reviewed, 2023-08-01)
      Background: Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of ...

    • Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors 

      Torgersen, Kristin Stensland; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean; Smeland, Olav Bjerkehagen; Munkhaugen, John; Djurovic, Srdjan; Dammen, Toril; Andreassen, Ole A. (Journal article; Peer reviewed, 2021)
      Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and coronary artery disease (CAD). The conditional/conjunctional false discovery rate method (cond/conjFDR) was applied to genome wide ...

    • Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood 

      Cheng, Weiqiu; van der Meer, Dennis; Parker, Nadine; Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean; Wang, Yunpeng; Shadrin, Alexey; Alnæs, Dag; Bahrami, Shahram; Lin, Aihua; Karadag, Naz; Holen, Børge; Fernández-Cabello, Sara; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Westlye, Lars Tjelta; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article; Peer reviewed, 2022)
      Patients with schizophrenia have consistently shown brain volumetric abnormalities, implicating both etiological and pathological processes. However, the genetic relationship between schizophrenia and brain volumetric ...

    • Shared genetic loci between depression and cardiometabolic traits 

      Torgersen, Kristin Stensland; Rahman, Zillur; Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Parker, Nadine; Frei, Oleksandr; Shadrin, Alexey; O'Connell, Kevin Sean; Tesli, Martin Steen; Smeland, Olav Bjerkehagen; Munkhaugen, John; Djurovic, Srdjan; Dammen, Toril; Andreassen, Ole (Journal article; Peer reviewed, 2022-05-13)
      Epidemiological and clinical studies have found associations between depression and cardiovascular disease risk factors, and coronary artery disease patients with depression have worse prognosis. The genetic relationship ...

    • Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities 

      Steen, Nils Eiel; Rahman, Zillur; Szabo, Attila; Hindley, Guy; Parker, Nadine; Cheng, Weiqiu; Lin, Aihua; O'Connell, Kevin S; Sheikh, Mashhood Ahmed; Shadrin, Alexey; Bahrami, Shahram; Karthikeyan, Sandeep; Hoseth, Eva Zsuzsanna; Dale, Anders M; Aukrust, Pål; Smeland, Olav Bjerkehagen; Ueland, Thor; Frei, Oleksandr; Djurovic, Srdjan; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Background: Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-wide association studies (GWAS) have identified genetic variants associated with SCZ and immune-related phenotypes. Here, we use cutting ...