Browsing Department of Clinical Science by Title
Now showing items 2038-2057 of 2318
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A short food frequency questionnaire to assess intake of seafood and n-3 supplements: validation with biomarkers
(Peer reviewed; Journal article, 2011-11-19)Background: Seafood intake is associated with beneficial effects for human health. Seafood provides a number of nutrients beyond the traditionally known long chain marine n-3 fatty acids EPA, DPA and DHA, such as protein, ... -
Short-term activation of peroxisome proliferator-activated receptors α and γ induces tissue-specific effects on lipid metabolism and fatty acid composition in male Wistar rats
(Peer reviewed; Journal article, 2019-06-12)Dietary fatty acids (FAs) affect certain metabolic routes, including pathways controlled by the peroxisome proliferator-activated receptors (PPARs), but tissue-specific effects are not well-defined. Thus, the aim was to ... -
Short-term outcome after open-heart surgery for severe chronic rheumatic heart disease in a low-income country, with comparison with an historical control group: an observational study
(Journal article; Peer reviewed, 2021)Objectives Rheumatic heart disease (RHD) is a major burden in low-income and middle-income countries (LMICs). Cardiac surgery is the only curative treatment. Little is known about patients with severe chronic RHD operated ... -
Short-term safety of COVID-19 mRNA vaccines with respect to all-cause mortality in the older population in Norway
(Journal article; Peer reviewed, 2022)Background There have been concerns about COVID-19 vaccination safety among frail older individuals. We investigated the relationship between COVID-19 mRNA vaccination and mortality among individuals aged ≥ 70 years and ... -
Short-term treatment with a peroxisome proliferator-activated receptor α agonist influences plasma one-carbon metabolites and B-vitamin status in rats
(Peer reviewed; Journal article, 2019-12-05)Introduction: Peroxisome proliferator-activated receptors (PPARs) have been suggested to be involved in the regulation of one-carbon metabolism. Previously we have reported effects on plasma concentrations of metabolites ... -
A short-time model to study relevant indices of cardiotoxicity of doxorubicin in the rat
(Peer reviewed; Journal article, 2013-07)Aim: Short-time models (STM) to study the cardiotoxicity (acute or chronic) of doxorubicin in rats are of interest to assess protective interventions and pathways. STM promotes more ethical animal treatment with less stress, ... -
Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells
(Peer reviewed; Journal article, 2016-11)Hydrogen sulfide (H2S) is an endogenous gasotransmitter in human physiology and inflammatory disease, however, with limited knowledge of how signal transduction pathways are involved in immune cells. To examine the effects ... -
A simple algorithm for the identification of clinical COPD phenotypes
(Peer reviewed; Journal article, 2017)This study aimed to identify simple rules for allocating chronic obstructive pulmonary disease (COPD) patients to clinical phenotypes identified by cluster analyses. Data from 2409 COPD patients of French/Belgian COPD ... -
A Simple Cervicovaginal Epigenetic Test for Screening and Rapid Triage of Women With Suspected Endometrial Cancer: Validation in Several Cohort and Case/Control Sets
(Journal article; Peer reviewed, 2022)PURPOSE Endometrial cancer (EC) incidence has been rising over the past 10 years. Delays in diagnosis reduce survival and necessitate more aggressive treatment. We aimed to develop and validate a simple, noninvasive, and ... -
Simplifying Treatment of Advanced Non-small Cell Lung Cancer : Regimen, Route of Administration, and Patients' Preferences
(Doctoral thesis, 2019-10-17)Lung cancer is the cancer disease that takes the most lives. Non-small cell lung cancer (NSCLC) is the most common type, and more than half have an incurable disease at the time of diagnosis. Chemotherapy can halt the ... -
Simultaneous Quantification of Aromatase Inhibitors and Estrogens in Postmenopausal Breast Cancer Patients
(Journal article; Peer reviewed, 2021)Context Currently there are no assays that can simultaneously quantify serum levels of the third-generation aromatase inhibitors (AIs): letrozole, anastrozole, and exemestane, and the ultra-low levels of estrogens in ... -
Single cell based phosphorylation profiling identifies alterations in toll-like receptor 7 and 9 signaling in patients with primary Sjögren's syndrome
(Peer reviewed; Journal article, 2019-02-21)Primary Sjögren's syndrome (pSS) is associated with polymorphisms and mRNA expression profiles that are indicative of an exaggerated innate and type I IFN immune response. Excessive activation potential of signaling pathways ... -
Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib
(Peer reviewed; Journal article, 2017-08)Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognosis, but has so far not been tested in a clinical trial of targeted ... -
Single cell signalling and immune cell profiling in psoriasis
(Doctoral thesis, 2021-02-19)Psoriasis is a common, chronic inflammatory skin disease with associated autoantigens, autoantibodies, local and systemic inflammation, and systemic comorbidities, such as cardiovascular disease and metabolic syndrome. ... -
Single dose vaccination of the ASO3-adjuvanted A (H1N1)pdm09 monovalent vaccine in health care workers elicits homologous and cross-reactive cellular and humoral responses to H1N1 strains
(Peer reviewed; Journal article, 2015)Healthcare workers (HCW) were prioritized for vaccination during the 2009 influenza A(H1N1)pdm09 pandemic. We conducted a clinical trial in October 2009 where 237 HCWs were immunized with a AS03-adjuvanted A(H1N1)pdm09 ... -
Single-cell profiling of low-stage endometrial cancers identifies low epithelial vimentin expression as a marker of recurrent disease
(Journal article; Peer reviewed, 2023)Background: Identification of aggressive low-stage endometrial cancers is challenging. So far, studies have failed to pinpoint robust features or biomarkers associated with risk of recurrence for these patients. Methods: ... -
Single-cell protein profiling in early therapy response evaluation of acute myeloid leukemia by mass cytometry
(Doctoral thesis, 2023-01-19)Akutt myelogen leukemi er ein aggressiv og heterogen form for blodkreft med om lag 150 nye tilfelle årleg i Noreg. Med ei total overlevingsrate på 25% har den dårlig prognose, særlig blant eldre. Behandlinga består av eit ... -
A site assessment tool for inpatient controlled human infection models for enteric disease pathogens
(Journal article; Peer reviewed, 2022)The use of the controlled human infection model to facilitate product development and to advance understanding of host-pathogen interactions is of increasing interest. While administering a virulent (or infective) organism ... -
Skåringsverktøy for tidlig oppdagelse av sepsis på sengepost
(Journal article; Peer reviewed, 2023)BAKGRUNN Sepsis er en av de vanligste årsakene til død i norske sykehus. Tilstanden er ofte oversett og behandlingen forsinket. Skåringsverktøy for å oppdage pasienter med sepsis er hyppigst undersøkt i akuttmottak, ...