Blar i Department of Clinical Science på tittel
Viser treff 1242-1261 av 2374
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Interleukin-6 in allogeneic stem cell transplantation: Its possible importance for immunoregulation and as a therapeutic target
(Peer reviewed; Journal article, 2017-06-08)Allogeneic stem cell transplantation is associated with a high risk of treatment-related mortality mainly caused by infections and graft-versus-host disease (GVHD). GVHD is characterized by severe immune dysregulation and ... -
Intermediate care in nursing home after hospital admission: a randomized controlled trial with one year follow-up
(Peer reviewed; Journal article, 2014-12-09)Background: Intermediate care is intended to reduce hospital admissions and facilitate early discharge. In Norway, a model was developed with transfer to intermediate care shortly after hospital admission. Efficacy and ... -
International REgistry to assess medical Practice with lOngitudinal obseRvation for Treatment of Heart Failure (REPORT-HF): Rationale for and design of a global registry
(Peer reviewed; Journal article, 2015-03-10)Aims. The clinical characteristics, initial presentation, management, and outcomes of patients hospitalized with new-onset (first diagnosis) heart failure (HF) or decompensation of chronic HF are poorly understood worldwide. ... -
Internet marketing of the herbal product ginger for use against nausea and vomiting
(Master thesis, 2010-05-16)Aim: The purpose of the study was to evaluate Internet marketing of ginger for use against nausea and vomiting during pregnancy (NVP) with particular focus on claims related to safety and efficacy in this indication. Method: ... -
Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability
(Journal article; Peer reviewed, 2023)Variability in disease severity caused by a microbial pathogen is impacted by each infection representing a unique combination of host and pathogen genomes. Here, we show that the outcome of invasive Streptococcus pyogenes ... -
The interplay between neoantigens and immune cells in sarcomas treated with checkpoint inhibition
(Journal article; Peer reviewed, 2023)Introduction: Sarcomas are comprised of diverse bone and connective tissue tumors with few effective therapeutic options for locally advanced unresectable and/or metastatic disease. Recent advances in immunotherapy, in ... -
The Interplay Between Prostate Cancer Genomics, Metabolism, and the Epigenome: Perspectives and Future Prospects
(Journal article; Peer reviewed, 2021)Prostate cancer is a high-incidence cancer, often detected late in life. The prostate gland is an accessory gland that secretes citrate; an impaired citrate secretion reflects imbalances in the activity of enzymes in the ... -
Interrelationships between anthropometric variables and overweight in childhood and adolescence
(Peer reviewed; Journal article, 2014-04-30)Objectives To answer the questions: how does body mass index (BMI) correlate to five overweight related anthropometric variables during different ages in childhood, and which anthropometric variables contribute most to ... -
Interstitial changes in spleen during sepsis
(Conference poster, 2014-09-26) -
Intestinal fermentation in patients with self-reported food hypersensitivity: painful, but protective?
(Peer reviewed; Journal article, 2010-07-03)Purpose: Enterometabolic disturbances may cause meal-related symptoms. We performed a functional evaluation of the intestinal microflora in patients with unexplained, self-reported food hypersensitivity by measuring fecal ... -
Intestinal microbiota and diet in IBS: causes, consequences, or epiphenomena?
(Peer reviewed; Journal article, 2015-01-27)Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, ... -
Intimal Hyperplasia. Experimental and Clinical Studies
(Doctoral thesis, 2014-10-27)Introduction: Intimal hyperplasia (IH) is recognized as the primary cause of reocclusion 2-24 months following vascular intervention and surgery, reportedly occurring in 30-50% of patients. It is an exaggerated form of the ... -
Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines
(Journal article; Peer reviewed, 2020)Cytidine deaminase (CDA) is a determinant of in vivo gemcitabine elimination kinetics and cellular toxicity. The impact of CDA activity in pancreatic ductal adenocarcinoma (PDAC) cell lines has not been elucidated. We ... -
Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells
(Peer reviewed; Journal article, 2019-07-06)Treatment with ultrasound and microbubbles (sonoporation) to enhance therapeutic efficacy in cancer therapy is rapidly expanding, but there is still very little consensus as to why it works. Despite the original assumption ... -
Intranasal H5N1 vaccines, adjuvanted with chitosan derivatives, protect ferrets against highly pathogenic influenza intranasal and intratracheal challenge
(Peer reviewed; Journal article, 2014-05-21)We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret ... -
Intranasal vaccination with a plant-derived H5 HA vaccine protects mice and ferrets against highly pathogenic avian influenza virus challenge
(Peer reviewed; Journal article, 2015-05)Highly pathogenic avian influenza H5N1 infection remains a public health threat and vaccination is the best measure of limiting the impact of a potential pandemic. Mucosal vaccines have the advantage of eliciting immune ... -
Intrauterine and genetic risk factors for proliferative diabetic retinopathy
(Doctoral thesis, 2022-05-13)Diabetes is a complex progressive metabolic disorder characterized by hyperglycemia and caused by different etiopathogenic factors. Individuals with diabetes have heterogeneous clinical representation and increased risk ... -
The intronic BRCA1 c.5407-25T>A variant causing partly skipping of exon 23—a likely pathogenic variant with reduced penetrance?
(Peer reviewed; Journal article, 2020-03-20)Rare sequence variants in the non-coding part of the BRCA genes are often reported as variants of uncertain significance (VUS), which leave patients and doctors in a challenging position. The aim of this study was to ... -
Investigating the human jejunal microbiota
(Journal article; Peer reviewed, 2022)Descriptions of the small intestinal microbiota are deficient and conflicting. We aimed to get a reliable description of the jejunal bacterial microbiota by investigating samples from two separate jejunal segments collected ... -
Investigating the human small intestinal microbiota : Microbiological characterization of jejunal and ileal samples collected during surgery
(Doctoral thesis, 2022-10-25)Kartlegging av tynntarmsmikrobiota hos mennesker : Mikrobiologisk beskrivelse av kirurgiske prøver fra jejunum og ileum Beskrivelser av tynntarmsmikrobiota (tarmflora) i lærebøker og vitenskapelige artikler er lite ...