Blar i Department of Clinical Science på tittel
Viser treff 1549-1568 av 2374
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A new software tool for computer assisted in vivo high-content analysis of transplanted fluorescent cells in intact zebrafish larvae
(Journal article; Peer reviewed, 2022)Acute myeloid leukemia and myelodysplastic syndromes are cancers of the bone marrow with poor prognosis in frail and older patients. To investigate cancer pathophysiology and therapies, confocal imaging of fluorescent ... -
New therapeutic targets in human acute myeloid leukemia
(Doctoral thesis, 2012-03-16) -
Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease
(Peer reviewed; Journal article, 2013-11-06)Background: Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was ... -
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
(Journal article; Peer reviewed, 2020)Obesity-related diseases (e.g. type 2 diabetes mellitus and cardiovascular disorders) represent an increasing health problem worldwide. NLRP3 inflammasome activation may underlie obesity-induced inflammation and insulin ... -
NLRP3 inflammasome promotes myocardial remodeling during diet-induced obesity
(Peer reviewed; Journal article, 2019-07-16)Background: Obesity is an increasingly prevalent metabolic disorder in the modern world and is associated with structural and functional changes in the heart. The NLRP3 inflammasome is an innate immune sensor that can be ... -
No asymptomatic malaria parasitaemia found among 108 young children at one health facility in Dar es Salaam, Tanzania
(Peer reviewed; Journal article, 2013-11-14)Background: Asymptomatic malaria parasitaemia has been reported in areas with high malaria transmission. It may serve as a reservoir for continued transmission, and furthermore complicates diagnostics, as not all individuals ... -
No difference in serum levels of B-cell activating receptor and antibodies against cytolethal distending toxin B and flagellin in post-infectious irritable bowel syndrome and chronic fatigue syndrome after Giardia infection
(Journal article; Peer reviewed, 2022)Background and Aim Functional gastrointestinal disorders (FGIDs) and chronic fatigue syndrome (CFS) frequently occur as comorbid conditions to each other. A shared etiology of these syndromes has been proposed because of ... -
No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris
(Journal article, 2020)Plasma concentrations of trimethylamine N-oxide (TMAO) have been linked to cardiovascular disease (CVD) risk and mortality. TMAO is formed through the bacterial conversion of trimethylamine which is obtained either directly ... -
No replication of previously reported association with genetic variants in the T cell receptor alpha (TRA) locus for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
(Journal article; Peer reviewed, 2022)Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with a variety of symptoms such as post-exertional malaise, fatigue, and pain, but where aetiology and pathogenesis are unknown. An increasing number ... -
No significant associations between breastfeeding practices and overweight in 8-year-old children
(Peer reviewed; Journal article, 2019)Aim: The aim was to examine if breastfeeding practices were associated with body mass index (BMI) and risk of overweight or obesity in third grade (8 years) of elementary school. Methods: In a regional cohort, we related ... -
No signs of neurodegenerative effects in 15q11.2 BP1-BP2 copy number variant carriers in the UK Biobank
(Journal article; Peer reviewed, 2023)The 15q11.2 BP1-BP2 copy number variant (CNV) is associated with altered brain morphology and risk for atypical development, including increased risk for schizophrenia and learning difficulties for the deletion. However, ... -
A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer
(Journal article; Peer reviewed, 2022-03-22)Background: miR-346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)-linked transcripts in prostate cancer (PC). We sought to delineate the impact of miR-346 ... -
NordAqua, a Nordic Center of Excellence to develop an algae-based photosynthetic production platform
(Journal article; Peer reviewed, 2021)NordAqua is a multidisciplinary Nordic Center of Excellence funded by NordForsk Bioeconomy program (2017–2022). The research center promotes Blue Bioeconomy and endeavours to reform the use of natural resources in a ... -
The Norwegian blood preparedness project: A whole blood program including civilian walking blood banks for early treatment of patients with life-threatening bleeding in municipal health care services, ambulance services, and rural hospitals
(Journal article; Peer reviewed, 2022)Background Civilian and military guidelines recommend early balanced transfusion to patients with life-threatening bleeding to improve survival. To provide the best care to patients with hemorrhagic shock in regions with ... -
Norwegian children and adolescents in blended families are at risk of larger one-year BMI increments
(Peer reviewed; Journal article, 2020)Aim: To study how sociodemographic factors and family structure associate with baseline BMI z‐scores (BMIz) and BMIz change in 767 Norwegian children aged 6‐15 years. Methods: Baseline BMIz and 1‐year BMIz increments in ... -
Novel adipose genes in substrate- and depot-dependent lipid accumulation
(Doctoral thesis, 2021-06-24)Altered adipose tissue function in obesity is linked to increased risk of type 2 diabetes (T2D) and cardiometabolic diseases via insulin resistance, visceral adiposity, hypertension, and other traits. This thesis studied ... -
A novel bicyclic lactone and other polyphenols from the commercially important vegetable Anthriscus cerefolium
(Journal article; Peer reviewed, 2022)Garden chervil, Anthriscus cerefolium (L.) Hoffm. is an important herb commonly applied in Norwegian large-scale commercial kitchens. This species is a highly enriched source of phenolics, containing 1260 mg gallic acid ... -
A novel case of impaired C-reactive protein response following open-heart surgery: A case report and review of the literature
(Journal article; Peer reviewed, 2021)Background C-reactive protein (CRP) is expected to increase in response to a range of inflammatory stimuli such as infections or extensive tissue trauma. Case report We present a novel case of severely impaired CRP ... -
A novel concentrated, interdisciplinary group rehabilitation program for patients with chronic obstructive pulmonary disease: Protocol for a nonrandomized clinical intervention study
(Journal article; Peer reviewed, 2022)Background: Pulmonary rehabilitation has been demonstrated to be a highly effective treatment for people with chronic obstructive pulmonary disease (COPD). However, its availability is scarce worldwide, and new and ... -
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function
(Peer reviewed; Journal article, 2019)Hemophagocytic lymphohistiocytosis (HLH) is characterized by immune dysregulation due to inadequate restraint of overactivated immune cells and is associated with a variable clinical spectrum having overlap with more common ...